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Transcranial Magnetic Stimulation
Frequency-Varied TMS for Depression
N/A
Waitlist Available
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Accompanied by at least two evidence-based augmentation therapies (Benzodiazepines do not count)
Must have confirmed diagnosis of severe Major Depressive Disorder (single or recurrent episode)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up weekly
Awards & highlights
Study Summary
This trial will study whether it is safe to give people transcranial magnetic stimulation (TMS) at different frequencies than the standard 10 Hz. TMS is a procedure used to treat depression. Up to 30 people will be enrolled and the trial will last 6 weeks.
Who is the study for?
This trial is for adults aged 18-65 with severe Major Depressive Disorder who haven't improved after at least four different antidepressant medications and two augmentation therapies. Participants must have tried effective psychotherapy and be able to commit to the study schedule.Check my eligibility
What is being tested?
The trial tests repetitive Transcranial Magnetic Stimulation (TMS) at non-standard frequencies for treating depression. It involves an initial assessment, determining treatment frequency/intensity, weekly mood checks, and up to 30 TMS sessions over six weeks.See study design
What are the potential side effects?
Potential side effects of TMS may include discomfort at the stimulation site, headache, lightheadedness, or a small risk of seizure. However, TMS is generally considered safe and well-tolerated.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am receiving two or more approved additional treatments (not including Benzodiazepines).
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I have been diagnosed with severe Major Depressive Disorder.
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My condition did not improve after trying two different types of treatment.
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I am between 18 and 65 years old.
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I have tried at least 4 different antidepressants without success.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ weekly
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~weekly
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Inventory of Depressive Symptoms- Self report
Trial Design
1Treatment groups
Experimental Treatment
Group I: SCCExperimental Treatment1 Intervention
Subjects will be treated according to their frequency response pattern which may show one or more distinct frequencies of stimulation that generated increased SCC
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Magnetic Stimulation
2017
Completed Phase 4
~730
Find a Location
Who is running the clinical trial?
University of California, Los AngelesLead Sponsor
1,528 Previous Clinical Trials
10,276,841 Total Patients Enrolled
101 Trials studying Depression
48,433 Patients Enrolled for Depression
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have an infection or poor skin condition on my scalp.I am unable to understand or sign the consent form due to mental or legal reasons.I have a neurological condition like epilepsy or severe head trauma.I am receiving two or more approved additional treatments (not including Benzodiazepines).I have been diagnosed with severe Major Depressive Disorder.My condition did not improve after trying two different types of treatment.I am between 18 and 65 years old.I have been diagnosed with a psychotic disorder during my current depressive episode.I have undergone psychotherapy for my depression.I am at a higher risk of having seizures due to family history, stroke, or my current medications.I have tried at least 4 different antidepressants without success.
Research Study Groups:
This trial has the following groups:- Group 1: SCC
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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