Portable Dynamic Chest X-Ray for ICU Patients
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new portable imaging technology called Dynamic Digital Radiography (DDR) to evaluate its effectiveness and safety in the ICU. DDR captures moving images of the lungs and provides detailed measurements of lung function, potentially offering better diagnostics than standard chest x-rays or CT scans. The trial aims to compare DDR images with regular scans to determine if DDR provides more precise information. Suitable participants for this trial include those in the ICU with breathing issues or lung problems. As an unphased trial, it offers participants the opportunity to contribute to innovative research that could enhance lung diagnostics in critical care settings.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications, so it's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this portable DDR machine is safe for ICU patients?
Research has shown that the portable dynamic digital radiography (DDR) machine has already received FDA approval, indicating some level of safety assurance. DDR captures many images quickly, similar to a short video, with radiation levels only slightly higher than a regular chest x-ray. This design ensures it remains safe and gentle on the body.
Although specific safety data from earlier studies is not provided, testing the machine in ICU settings suggests it is expected to be well-tolerated by patients who are already very ill. This trial is the first to use a portable version of DDR in this setting, aiming to confirm its safety and practicality for bedside use.
Overall, since DDR employs technology similar to traditional x-rays and has existing FDA approval, it is expected to be safe for human use.12345Why are researchers excited about this trial?
Researchers are excited about Portable Dynamic Digital Radiography (DDR) because it offers a more advanced way to assess lung function in ICU patients compared to traditional chest x-rays, ultrasounds, or VQ scans. Unlike standard imaging, DDR captures dynamic images at a rate of 15 frames per second, providing detailed insights into lung motion, ventilation, and perfusion. This method acts like a mini-fluorography machine but with only slightly more radiation than a standard chest x-ray, potentially offering a safer and more informative option for critical care settings.
What evidence suggests that this portable DDR is effective for ICU patients?
Research has shown that Portable Dynamic Digital Radiography (DDR), provided to participants in this trial alongside clinical gold standard imaging, delivers faster image results than older systems, enhancing ICU workflow. DDR captures moving images of the chest, offering detailed views of lung movement, breathing, and blood circulation, which can be more informative than traditional chest X-rays. Specifically, studies have demonstrated that DDR's capability to capture moving images at 15 frames per second can lead to more accurate diagnoses. By offering a clearer picture of lung function, DDR may assist doctors in making better decisions about patient care.12345
Who Is on the Research Team?
Bruno Madore, PhD
Principal Investigator
Brigham and Women's Hospital
Hiroto Hatabu, MD PhD
Principal Investigator
Brigham and Women's Hospital
Gyorgy Frendl, MD, PhD
Principal Investigator
Brigham and Women's Hospital
Are You a Good Fit for This Trial?
This trial is for ICU patients with various lung conditions like pneumonia, COPD, or rib fractures. It's testing a new portable chest X-ray machine called DDR. To join, patients must be in the ICU and could benefit from advanced lung imaging.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging and Comparison
Participants receive one to three sets of DDR images, which are compared to clinical gold standard exams to assess precision and accuracy of measurements such as diaphragmatic motion, lung movement, and perfusion.
Follow-up
Participants are monitored for safety and effectiveness after imaging procedures.
What Are the Treatments Tested in This Trial?
Interventions
- Portable Dynamic Digital Radiography (DDR)
Portable Dynamic Digital Radiography (DDR) is already approved in United States for the following indications:
- Assessment of lung motion, ventilation, and perfusion in ICU patients
Find a Clinic Near You
Who Is Running the Clinical Trial?
Brigham and Women's Hospital
Lead Sponsor
Konica Minolta
Collaborator