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Fear Conditioning Interventions for PTSD

N/A
Recruiting
Led By Mohammed Milad
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
a. Diagnosis of current PTSD (as determined by CAPS, and primary diagnosis of PTSD as determined by SCID assessment of comorbidity)
18 - 70 years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up experimental day 1, experimental day 2
Awards & highlights

Study Summary

This trial is measuring how the brain learns to avoid certain stimuli or situations, and how fear extinction and cost can change that.

Who is the study for?
This trial is for adults aged 18-70 with current PTSD, diagnosed through specific assessments (CAPS and SCID). It's also open to trauma-exposed healthy controls without any history of psychiatric disorders or PTSD. Participants must be willing to undergo experiments involving avoidance of stimuli.Check my eligibility
What is being tested?
The study tests how people with PTSD learn to avoid things that scare them. It involves measuring brain responses and feelings during tasks like paying to avoid shocks, learning about fear, avoiding conditioned stimuli, and overcoming learned fears.See study design
What are the potential side effects?
Since this is a psychological study involving fear and avoidance behaviors, participants may experience increased anxiety or stress during the tasks. However, there are no physical side effects as it does not involve medication or invasive procedures.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with PTSD as my primary condition.
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I am between 18 and 70 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~experimental day 1, experimental day 2
This trial's timeline: 3 weeks for screening, Varies for treatment, and experimental day 1, experimental day 2 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Comparison of Skin Conductance Response (SCR) of PTSD participants and Trauma-Exposed Healthy Controls
Post-Traumatic Stress Disorder
Secondary outcome measures
Change in Anxiety
Change in Emotional Stress tolerance
Change in shock expectancy
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Trauma-Exposed Healthy Controls (TEHC)Experimental Treatment4 Interventions
After the initial screening / baseline assessment visit, trauma-exposed healthy participants will undergo two Experimental Visits, which included participation in an emotional learning paradigm and an fMRI scan over the course of two consecutive days. Participants will be asked to look at pictures on a computer screen to measure physiological response physiological response (skin conductance response) and brain responses using a functional Magnetic Resonance Imaging (fMRI) machine. These two visits will be scheduled within a month from the baseline assessment visit.
Group II: PTSD groupExperimental Treatment4 Interventions
After the initial screening / baseline assessment visit, Post Traumatic Stress Disorder participants will undergo two Experimental Visits, which included participation in an emotional learning paradigm and an fMRI scan over the course of two consecutive days. Participants will be asked to look at pictures on a computer screen to measure physiological response physiological response (skin conductance response) and brain responses using a functional Magnetic Resonance Imaging (fMRI) machine. These two visits will be scheduled within a month from the baseline assessment visit.

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,786 Previous Clinical Trials
2,689,467 Total Patients Enrolled
NYU Langone HealthLead Sponsor
1,369 Previous Clinical Trials
840,335 Total Patients Enrolled
Mohammed MiladPrincipal InvestigatorNYU Langone

Media Library

Avoidance conditioning Clinical Trial Eligibility Overview. Trial Name: NCT04770584 — N/A
Post-Traumatic Stress Disorder Research Study Groups: PTSD group, Trauma-Exposed Healthy Controls (TEHC)
Post-Traumatic Stress Disorder Clinical Trial 2023: Avoidance conditioning Highlights & Side Effects. Trial Name: NCT04770584 — N/A
Avoidance conditioning 2023 Treatment Timeline for Medical Study. Trial Name: NCT04770584 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many research subjects are currently participating in this investigation?

"Affirmative. Clinicaltrials.gov holds evidence that this experiment, which was posted on July 1st 2021, is currently recruiting participants. 300 volunteers need to be recruited from a single site."

Answered by AI

Is enrollment still open for potential participants of this trial?

"Clinicaltrials.gov indicates that this research endeavour is currently seeking volunteers, with the initial posting being on July 1st of 2021 and last updated February 18th 2022."

Answered by AI

Am I eligible to participate in this investigation?

"This scientific trial is currently seeking 300 individuals between the ages of 18 and 70 who are suffering from post-traumatic stress disorder (PTSD). It is expected that they also meet several additional requirements, such as being female or male, having a PTSD diagnosis validated through CAPS and SCID assessments, no history of Axis I psychiatric disorders nor prior PTSD cases; trauma exposure must be documented in medical records. Furthermore, volunteers need to both consent for their participation willingly and understand what it implies."

Answered by AI

Is the upper age limit for this clinical trial set at 85 or higher?

"This clinical trial is recruiting participants aged 18 to 70. There are 46 studies that target minors and 329 trials seeking patients over 65 years old."

Answered by AI

What successes are hoped for as a result of this experiment?

"This experimental trial will gauge the Skin Conductance Response (SCR) of PTSD victims and trauma-exposed healthy individuals over two days. Auxiliary objectives include measuring shock expectancy, evaluating the unpleasantness associated with conditioned stimuli and unconditioned stimulus on a 1 to 5 scale, as well as rating pleasantness when no shocks are administered using an analogous metric."

Answered by AI

Who else is applying?

What state do they live in?
New York
How old are they?
18 - 65
What site did they apply to?
NYU Langone Health
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
3+

Why did patients apply to this trial?

Just want to try something new.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Fear and Avoidance in PTSD Patients
2021. "Fear and Avoidance in PTSD Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04770584.
All > Ptsd New York
~111 spots leftby Jan 2026
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