Tb Clinical Trials
Here are the 6 most popular medical studies for tb
Behavioural Intervention
Standard of Care Balance Intervention +2 More for Traumatic Brain Injury
This research study evaluates the effectiveness of a low-cost Virtual Reality-based (VR) training system in providing a customized balance treatment in a skilled clinical setting. Participants will be assigned to one of three treatment groups.
Behavioural Intervention
Biological Maternal Sounds for Premature Birth
The purpose of this RCT is to learn more about how sounds that we experience in the womb can affect early development in premature infants. The investigators are specifically interested determining whether and what types of maternal sensory stimulation can influence physical growth, brain maturation, respiratory stability and early vocalization during postnatal development. The investigators hypothesize that daily exposure to biological maternal sounds, such as mother's voice and heartbeat, will improve both short-term and long-term developmental in premature infants and will increase their potential to grow into healthy children.
Behavioral Intervention
RT fMRI + Cognitive Training for Traumatic Brain Injury
This trial will test the effects of two different types of training on cognitive abilities and symptoms in people with brain injuries. Brain function and structure will be measured before and after the training.
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Concussion Clinical Trials
View 51 Concussion medical studies.
Behavioral Intervention
Neural Pathfinder Training for Traumatic Brain Injury
Injury to the brain can change the core of a person's being, affecting brain functions necessary to accomplish important goals in a complex world. Deficits in attention, working memory, and other aspects of goal-directed cognition affect a broad range of pursuits in everyday life, and are among the most prevalent and long-lasting consequences of brain injuries. The objective of this research is to develop remotely deployed training tools that target the most common, persistent and debilitating cognitive functions affected by traumatic brain injury (TBI); test the potential effects of the intervention and compare these effects to an active comparison intervention; and determine the neurocognitive and functional effects of computer-assisted remote training.
Behavioural Intervention
rTMS +1 More for Traumatic Brain Injury
This trial is studying the effects of a brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) on people who have remained in a vegetative or minimally conscious state for 3-24 months after a severe traumatic brain injury (TBI).
Behavioural Intervention
Cogmed Working Memory Training for Traumatic Brain Injury
Traumatic Brain Injury (TBI) is the most common cause of death and long-term disability in children. Much of the long-term disability stems from neurocognitive impairments that are not greatly helped by current cognitive training and pharmacological treatments for TBI related cognitive impairments. This study tests the hypothesis that a drug, D-cycloserine (DCS), will significantly enhance the effect of cognitive training in correcting cognitive impairments in children with moderate/severe TBIs. In order to do so, study subjects who fit inclusion criteria, including those with moderate to severe TBI who show persistent working memory weaknesses based on a screening, will be recruited. They will have three visits to UCLA. During the first visit, subjects will undergo an MRI protocol before and after taking a pill (drug or placebo, blinded). They will also participate in a number of paper and pencil cognitive tests. Then subjects will be enrolled in a 6 week computerized cognitive training program (CogMed). They will also be prescribed a drug/placebo pill (depending on which group they are randomized into), which they'll have to take at regular intervals during the 6 weeks. They will have weekly check in phone calls or visits by a coach trained in the program to make sure they are following the study protocol accurately, to have their questions answered, and for motivation. At the end of the training period, subjects will return to UCLA to again complete the MRI protocol and cognitive testing. After three months of enrollment, they will have a final visit to UCLA, including only cognitive testing. A total of 30 subjects will be entered into the study.
Traumatic Brain Injury Clinical Trials
View 46 Traumatic Brain Injury medical studies.
Behavioral Intervention
Neural Pathfinder Training for Traumatic Brain Injury
Injury to the brain can change the core of a person's being, affecting brain functions necessary to accomplish important goals in a complex world. Deficits in attention, working memory, and other aspects of goal-directed cognition affect a broad range of pursuits in everyday life, and are among the most prevalent and long-lasting consequences of brain injuries. The objective of this research is to develop remotely deployed training tools that target the most common, persistent and debilitating cognitive functions affected by traumatic brain injury (TBI); test the potential effects of the intervention and compare these effects to an active comparison intervention; and determine the neurocognitive and functional effects of computer-assisted remote training.
Behavioural Intervention
rTMS +1 More for Traumatic Brain Injury
This trial is studying the effects of a brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) on people who have remained in a vegetative or minimally conscious state for 3-24 months after a severe traumatic brain injury (TBI).
Behavioural Intervention
Cogmed Working Memory Training for Traumatic Brain Injury
Traumatic Brain Injury (TBI) is the most common cause of death and long-term disability in children. Much of the long-term disability stems from neurocognitive impairments that are not greatly helped by current cognitive training and pharmacological treatments for TBI related cognitive impairments. This study tests the hypothesis that a drug, D-cycloserine (DCS), will significantly enhance the effect of cognitive training in correcting cognitive impairments in children with moderate/severe TBIs. In order to do so, study subjects who fit inclusion criteria, including those with moderate to severe TBI who show persistent working memory weaknesses based on a screening, will be recruited. They will have three visits to UCLA. During the first visit, subjects will undergo an MRI protocol before and after taking a pill (drug or placebo, blinded). They will also participate in a number of paper and pencil cognitive tests. Then subjects will be enrolled in a 6 week computerized cognitive training program (CogMed). They will also be prescribed a drug/placebo pill (depending on which group they are randomized into), which they'll have to take at regular intervals during the 6 weeks. They will have weekly check in phone calls or visits by a coach trained in the program to make sure they are following the study protocol accurately, to have their questions answered, and for motivation. At the end of the training period, subjects will return to UCLA to again complete the MRI protocol and cognitive testing. After three months of enrollment, they will have a final visit to UCLA, including only cognitive testing. A total of 30 subjects will be entered into the study.
Phase 3 Tb Clinical Trials
View 98 phase 3 tb medical studies.
Procedure
Hyperbaric Oxygen for Traumatic Brain Injury
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of mild traumatic brain injury (mTBI).
Antibiotic
Rifapentine-Based Regimens for Latent Tuberculosis
This trial is being conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care, control arm) of latent M. tuberculosis infection (LTBI).
Enzyme Replacement Therapy
Cipaglucosidase Alfa + Miglustat for Pompe Disease
This trial will study the safety and effectiveness of Cipaglucosidase Alfa/Miglustat in treating Pompe disease in children who have either received enzyme replacement therapy before or have not.
Tb Clinical Trials With No Placebo
View 98 tb medical studies that do not have a placebo group.
Antibiotic
Pretomanid for Kidney Failure
This trial is a Phase I, open-label, single dose, sequential group study to compare the safety and pharmacokinetics of pretomanid in subjects with severe renal impairment including those with End Stage Renal Disease (ESRD) not needing dialysis, subjects with mild or moderate renal impairment, and subjects with normal renal function. The primary objective is to evaluate the PK profiles of pretomanid in plasma and urine after a single oral dose of 200 mg in subjects with renal impairment compared to matched healthy controls.
Behavioral Intervention
Neural Pathfinder Training for Traumatic Brain Injury
Injury to the brain can change the core of a person's being, affecting brain functions necessary to accomplish important goals in a complex world. Deficits in attention, working memory, and other aspects of goal-directed cognition affect a broad range of pursuits in everyday life, and are among the most prevalent and long-lasting consequences of brain injuries. The objective of this research is to develop remotely deployed training tools that target the most common, persistent and debilitating cognitive functions affected by traumatic brain injury (TBI); test the potential effects of the intervention and compare these effects to an active comparison intervention; and determine the neurocognitive and functional effects of computer-assisted remote training.
Cell phone intervention arm for Latent Tuberculosis Infection
This study will examine the impact of use of mobile phones and text messaging on adherence to treatment for patients with latent TB infection. Half (50%) of the 350 anticipated study participants will receive weekly text messages inquiring on their health status in relation to their prescribed treatment, while the other half (50%) will not receive weekly text messages at all. Medical adherence will be assessed by monthly blood-work, clinic visits and by interviewing patients at each of these visits. The investigators hypothesis is that enhanced communication with a health care provider, via a structured cell phone SMS text messaging based program (WelTel), will result in a 15% improvement in the proportion of patients who successfully complete their LTBI treatment regimens.
Alpha-2 Adrenergic Agonist
Dexmedetomidine +1 More for Lung Cancer
Lung cancer is the second most commonly diagnosed primary neoplasia in Canada accounting for 22 865 new cases in 2007. Recent randomized trials have shown a significantly better diagnostic yield and fewer unnecessary thoracotomies with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) when compared to conventional TBNA for various clinical conditions including peripheral pulmonary lesions and sarcoidosis. EBUS-TBNA are now routinely performed in our institution for staging of pulmonary and mediastinal cancer. EBUS-TBNA are performed under monitored anesthesia care (MAC) in the endoscopy suite at the Centre de soins ambulatoires of the Hôpital Maisonneuve-Rosemont. Remifentanil, used in combined regime or as single agent proved to be effective and safe for MAC. Nonetheless, anesthesiologists are still confronted to the respiratory depression profile of remifentanil and other commonly used agents. An analysis of the ASA Closed Claims demonstrated that respiratory depression remains a significant drawback during MAC in remote locations. Furthermore, patients with coexisting pulmonary diseases scheduled for EBUS-TBNA are at increased risk of such complications. The investigators hypothesize that compared to the use of remifentanil-based MAC protocol, the use of dexmedetomidine-based MAC protocol for EBUS-TBNA will result in a lower incidence of major respiratory and hemodynamic adverse events (bradypnea, apnea, oxygen desaturation, hypotension, hypertension, bradycardia and tachycardia) with equivalent overall procedure conditions.
Cell Transfer Therapy
Cell Therapy + Chemo + TBI for Skin Cancer
This trial is testing whether an experimental treatment for metastatic melanoma, which involves cell therapy, is more effective when given with chemotherapy and total body irradiation, or just with chemotherapy.
Behavioral Intervention
Early weight-bearing and range of motion exercises +1 More for Ankle Injury
The primary objective of the investigators randomized controlled trial is to determine if early protected weightbearing and ankle range of motion after surgical treatment (open reduction internal fixation - ORIF) for ankle fractures improves the rate of return to work and functional outcome compared to postoperative ankle immobilization in a non-weightbearing cast.
View More Tb Trials
See another 72 medical studies focused on tb.
Frequently Asked Questions
Introduction to tb
What are the top hospitals conducting tb research?
While tuberculosis (TB) may not be as commonly discussed as some other diseases, pioneering hospitals are actively engaged in clinical trials to combat this global health threat. In East Hanover, the Kessler Foundation is making strides with four ongoing TB trials. Although they have yet to conduct any previous trials on TB, their dedication and commitment to finding effective treatments are evident. Similarly, the City of Hope Medical Center in Duarte has three active TB trials underway and no prior history of conducting such studies.
The National Institutes of Health Clinical Center in Bethesda has also dedicated its resources to tackle this infectious disease. With three currently active TB trials and a cumulative total of five completed studies since their first recorded trial back in 2011, they continue to contribute valuable knowledge towards understanding and combating TB.
Meanwhile, the Kessler Foundation in West Orange is actively engaged in three ongoing clinical trials for tuberculosis without any past records of conducting similar investigations. Lastly, at the University of Miami in sunny Miami itself focus lies upon two current tb cases under consideration; however without much past evidence found regarding tbs earlier experiments here.
These institutions exemplify both innovation and determination within the medical community's fight against tuberculosis—a serious condition affecting millions worldwide. Through these clinical trials conducted across various locations across the country like East Hanover or Duarte where patients might find themselves supported by cutting-edge research led by healthcare professionals who strive for better outcomes every single day.The collective efforts undertaken by these esteemed hospitals bring hope for advancements that will alleviate suffering caused by this persistent disease
Which are the best cities for tb clinical trials?
When it comes to TB clinical trials, several cities in the United States are at the forefront of research and development. Houston, Texas leads with 8 active trials focusing on a range of treatments such as DRL_RI (Proposed rituximab biosimilar), breast cancer, and Donepezil. Baltimore, Maryland closely follows with 8 ongoing studies exploring interventions like Asundexian and Emetine. Bethesda, Maryland also shows promise with 7 active trials investigating Total Body Irradiation (TBI), Pheripheral blood stem cells, and more. Seattle, Washington contributes to the field with 6 active trials including Bilingual Brain injury Education and outpatient Navigation for Hispanic families. Finally, Portland, Oregon offers its own contributions through ongoing studies on breast cancer and branched chain amino acids. These cities serve as important hubs for TB clinical research in their dedication to finding better treatment options for patients worldwide.
Which are the top treatments for tb being explored in clinical trials?
Clinical trials are actively exploring potential treatments for tuberculosis (TB), with one standout contender leading the pack. MK-7762, also known as TBD09, has emerged as a promising option in the fight against TB. Currently, there is one active trial dedicated to assessing its efficacy and safety. Despite being a newcomer on the scene since 2023, this innovative treatment shows great potential in potentially revolutionizing TB management and improving patient outcomes.
What are the most recent clinical trials for tb?
Recent clinical trials have brought new hope for the treatment of tuberculosis (TB). One notable study is focused on emetine, which has progressed to Phase 2 and Phase 3 trials as a potential therapy for TB. Another trial explores an experimental treatment in its early stages (Phase 1) that aims to address this infectious disease. Additionally, researchers are investigating the use of pregnenolone as a possible intervention for TB, with promising results from Phase 2 trials. These advancements signify significant progress in our understanding and management of this global health issue.
What tb clinical trials were recently completed?
A recent milestone has been reached in tuberculosis (TB) research with the completion of a clinical trial investigating Imatinib, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID). In October 2020, this trial concluded, bringing us closer to potentially improved treatment options for TB. With ongoing efforts like these, researchers are dedicated to combatting this infectious disease and making significant strides towards better outcomes for patients.