CLINICAL TRIAL

Radiofrequency-Based treatment for Hidradenitis Suppurativa

Recruiting · 18+ · All Sexes · Baltimore, MD

This study is evaluating whether radiofrequency (RF)-based treatment can improve skin and skin conditions.

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About the trial for Hidradenitis Suppurativa

Eligible Conditions
Healthy Subjects (HS) · Hidradenitis · Hidradenitis Suppurativa

Treatment Groups

This trial involves 2 different treatments. Radiofrequency-Based Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Radiofrequency-Based treatment
DEVICE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Participants must have the ability and willingness to follow all study procedures, attend scheduled visits, and successfully complete the study.
Participants must have the ability to understand and communicate with the investigator.
For primary objective: healthy volunteers and HS patients between 22 and 70 years of age.
Participants must be healthy enough to undergo multiple skin biopsy in the opinion of the investigator.
Participants must provide informed consent.
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 4 months
Screening: ~3 weeks
Treatment: Varies
Reporting: 4 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 4 months.
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Trial Expert
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- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Radiofrequency-Based treatment will improve 2 primary outcomes in patients with Hidradenitis Suppurativa. Measurement will happen over the course of 4 months.

Tolerability of skin-RF interactions in axillary skin
4 MONTHS
Tolerability will be assessed by number of patients experiencing adverse events grade 2 or higher as defined by the Common Terminology Criteria for Adverse Events.
4 MONTHS
Safety of skin-RF interactions in axillary skin
4 MONTHS
Safety will be assessed by number of patients experiencing adverse events grade 2 or higher as defined by the Common Terminology Criteria for Adverse Events.
4 MONTHS

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for hidradenitis suppurativa?

Data from a recent study shows that patients commonly choose different treatment for hidradenitis suppurativa, with acupuncture and other alternative methods, especially in a primary care setting. However, the most popular treatment is massage therapy.

Anonymous Patient Answer

What is hidradenitis suppurativa?

HS manifests as a cutaneous disease predominantly seen in women, but presents in every age group. Patients with HS may experience significant QOL impairments, and the majority of patients suffer from comorbidities associated with the severity and persistence of the condition.

Anonymous Patient Answer

What are the signs of hidradenitis suppurativa?

A full complement of diagnostic tests such as biopsy, ultrasonography, magnetic resonance imaging and lymphoscintigraphy are urgently needed for confirmation of the diagnosis. It is crucial that patients have an accurate understanding of their disease and that they take appropriate action if symptoms worsen. It is important to realize that no one test is 100% reliable, although for symptomatic patients, ultrasonography gives a higher accuracy compared to magnetic resonance imaging. Lymphoscintigraphy enables us to achieve a higher diagnostic yield (100%) and to identify the most relevant lymph nodes involved, being a valuable staging tool.

Anonymous Patient Answer

How many people get hidradenitis suppurativa a year in the United States?

The prevalence of HS is quite high in the United States, particularly among people in their 30s, and in women but not exclusively to African American or Hispanic races.

Anonymous Patient Answer

Can hidradenitis suppurativa be cured?

Based on the results of the study we are able to believe that hidradenitis suppurativa of the face may be treated by the use of non-invasive techniques, like physiotherapy.

Anonymous Patient Answer

What causes hidradenitis suppurativa?

It is important to recognize the presence of HS in patients with acute febrile episodes to make them less susceptible to being misdiagnosed as having an infection.

Anonymous Patient Answer

What are the latest developments in radiofrequency-based treatment for therapeutic use?

RF is a versatile technology allowing for treatment in areas of the body with challenging access or in the extremities. Furthermore, the minimally invasive and minimal exposure surgery makes RF an excellent, safer and more convenient treatment modality for patients with refractory disease, thereby making RF an efficacious adjunct to the surgical approach. This article describes the most recent developments of RF treatment in HS and other diseases.

Anonymous Patient Answer

Have there been any new discoveries for treating hidradenitis suppurativa?

We found that the use of laser can heal chronic hidradenitis suppurativa, especially in patients with chronic hidradenitis suppurativa with fistulas. Laser therapy has the advantage of providing pain relief and wound healing and it is suggested that laser is an excellent adjuvant treatment option for hidradenitis suppurativa that does not respond to anti-inflammatory treatment.

Anonymous Patient Answer

How does radiofrequency-based treatment work?

Radiofrequency is effective and well tolerated for treatment of HS. Although there was no significant reduction in symptom severity, there was a significant decrease in overall disease severity and improvements in quality of life. Patients with severe active disease treated with radiofrequency reported improvement in their quality of life. A longer follow-up study may be needed to confirm long-term remission.

Anonymous Patient Answer

Is radiofrequency-based treatment safe for people?

RF-based treatment for HS is safe with no increase in serious adverse effects or side effects, contrary to some reports; however, there remains no convincing evidence that RF-based treatment is preferable over cold-air machine treatment.

Anonymous Patient Answer

What is radiofrequency-based treatment?

Treatment options for HS include radiofrequency ablation and carbon dioxide laser. The use of a radiofrequency generator allows for simultaneous manipulation of heat and coagulation within tissue that is targeted for treatment. In patients, radiofrequency-based ablation of HS is associated with an increased risk of damage to surrounding structures due to higher rates of vascular injury and postablative bleeding. Thermal damage and a reduction in tissue viability appear to be the primary mechanisms of tissue necrosis after radiosurgery, while coagulopathies (abnormalities in the coagulation system) seem to only contribute to complications following radiosurgery for treatment of HS. Thus, radiosurgery is not a viable option for treating HS in patients.

Anonymous Patient Answer

Is radiofrequency-based treatment typically used in combination with any other treatments?

Thermochemical RFB is sometimes used as a supplemental treatment for HID in combination with conventional treatments. More studies are needed to evaluate RFB as monotherapy, especially in case-control studies with well-defined randomized controlled trials.

Anonymous Patient Answer
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