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Ultraviolet B Radiation for Skin Cancer

N/A
Recruiting
Led By Jeffrey B Travers, MD, PhD
Research Sponsored by Jeffrey B. Travers, MD, PhD
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 to 40
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after 1 hour incubation from ultraviolet b radiation exposure.
Awards & highlights

Study Summary

This trial will study how well the skin of night shift workers responds to artificial sunlight, compared to those who work during the day.

Who is the study for?
This trial is for adults aged 18-40 with fair skin who work night shifts or a mix of day and night but mostly at night. They should be able to document their work schedule for the past three months. It's not open to those on hormonal treatments, allergic to lidocaine, pregnant/nursing women, people with serious health issues, abnormal scarring, skin infections/cancers, photosensitivity issues, sleep disorders like apnea/insomnia or diabetes.Check my eligibility
What is being tested?
The study aims to understand how the skin of night shift workers reacts to artificial sunlight (UVB radiation) compared to day workers by exposing their biopsied skin samples in a lab setting. The response of the skin cells will help determine if working hours affect DNA repair activity related to potential skin cancer risk.See study design
What are the potential side effects?
Since this trial involves exposure of biopsied skin tissue rather than direct treatment of participants themselves with UVB radiation or other interventions, there are no side effects associated directly with the interventions being studied.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 40 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 1 hour incubation from ultraviolet b radiation exposure.
This trial's timeline: 3 weeks for screening, Varies for treatment, and after 1 hour incubation from ultraviolet b radiation exposure. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Activation of DNA damage kinase signaling pathways at two times of the day in the skin of day and night shift workers.
Activity of the nucleotide excision repair (NER) system at two times of the day in day and night shift workers.
Expression level of the DNA repair factor XPA at two times of the day in the skin of day and night shift workers.
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Night Shift Work ScheduleExperimental Treatment2 Interventions
Night shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.
Group II: Day Shift Work ScheduleExperimental Treatment2 Interventions
Day shift worker skin biopsies will be exposed to artificial sunlight (ultraviolet B radiation; UVB) at the laboratory.

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Who is running the clinical trial?

Jeffrey B. Travers, MD, PhDLead Sponsor
4 Previous Clinical Trials
108 Total Patients Enrolled
Wright State UniversityLead Sponsor
41 Previous Clinical Trials
54,834 Total Patients Enrolled
Jeffrey B Travers, MD, PhDPrincipal InvestigatorWright State University
9 Previous Clinical Trials
212 Total Patients Enrolled

Media Library

Ultraviolet B Radiation Clinical Trial Eligibility Overview. Trial Name: NCT04122456 — N/A
Skin Cancer Research Study Groups: Night Shift Work Schedule, Day Shift Work Schedule
Skin Cancer Clinical Trial 2023: Ultraviolet B Radiation Highlights & Side Effects. Trial Name: NCT04122456 — N/A
Ultraviolet B Radiation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04122456 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
DNA Repair Activity in the Skin of Day and Night Shift Workers
Jeffrey B. Travers, MD, PhD 2022. "DNA Repair Activity in the Skin of Day and Night Shift Workers". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04122456.
~26 spots leftby Dec 2025
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