Lo/Ovral-28

Birth Control, Acne Vulgaris, Folate supplementation therapy + 5 more
Treatment
1 FDA approval
20 Active Studies for Lo/Ovral-28

What is Lo/Ovral-28

EthinylestradiolThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic hormone developed in 1938 that has greater absorption into the body when taken by mouth compared to other forms of estrogen. It is used in many contraceptives and was approved by the FDA in 1943.
LOESTRIN Fe 1.5/30is the brand name
image of different drug pills on a surface
Lo/Ovral-28 Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679

Approved as Treatment by the FDA

Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .
Birth Control
Used to treat Contraception in combination with Levonorgestrel

Effectiveness

How Lo/Ovral-28 Affects PatientsEthinylestradiol is a type of synthetic estrogen that helps to prevent ovulation by decreasing hormones in the body. It is safe to take once per day, and the risk of serious side effects from an overdose are low. However, patients should be aware of the increased risk of blood clotting associated with this drug.
How Lo/Ovral-28 works in the bodyEthinylestradiol is a synthetic hormone used in some contraceptive pills. It works by making the mucus in the cervix thicker, preventing sperm from entering the uterus. It also suppresses the hormones that normally trigger ovulation. Additionally, it reduces blood flow to the endometrium, making it harder for a fertilized egg to implant. Finally, it increases the amount of a protein that binds to hormones, making them less effective in the body.

When to interrupt dosage

The measure of Lo/Ovral-28 relies upon the diagnosed state, including Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The sum of dosage is contingent upon the method of administration detailed in the table below.
Condition
Dosage
Administration
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral
Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, film coated - Oral, Tablet, film coated, Patch, Patch - Transdermal, Capsule, Tablet, chewable - Oral, Capsule - Oral

Warnings

Lo/Ovral-28 has twenty-six contraindications and should not be employed in cases of the conditions provided in the following table.Lo/Ovral-28 Contraindications
Condition
Risk Level
Notes
Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
Venous Thrombosis
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Disease
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Liver Neoplasms
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Fibrosis
Do Not Combine
Breast
Do Not Combine
Renal Insufficiency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
There are 20 known major drug interactions with Lo/Ovral-28.
Common Lo/Ovral-28 Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Lo/Ovral-28 Toxicity & Overdose RiskWomen overdosing on estrogen may experience bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment for this type of overdose should include addressing symptoms, monitoring for potassium and sodium levels, and checking for signs of metabolic acidosis.
image of a doctor in a lab doing drug, clinical research

Lo/Ovral-28 Novel Uses: Which Conditions Have a Clinical Trial Featuring Lo/Ovral-28?

38 active trials are presently examining the utility of Lo/Ovral-28 to furnish Folate supplementation therapy, ameliorate Premenstrual Dysphoric Disorder and reduce the symptoms of Menopause.
Condition
Clinical Trials
Trial Phases
Birth Control
22 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2
Hormonal Contraception
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Patient desires oral contraception for birth control
0 Actively Recruiting
Osteoporosis
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Menopause
0 Actively Recruiting

Lo/Ovral-28 Reviews: What are patients saying about Lo/Ovral-28?

5Patient Review
9/14/2011
Lo/Ovral-28 for Birth Control
I've been on this pill for over 15 years without any issues. Unfortunately, the clinic I was going to stopped carrying it and switched me to Levora. I had nothing but problems with Levora, including a decreased sex drive. I'm coming back to this pill before Levora ruins my relationship.
5Patient Review
4/20/2012
Lo/Ovral-28 for Endometriosis
This medication has been a total life-saver for me. I have long, painful periods as well as endometriosis, so being on birth control is a must for me. I've tried several different kinds and this one is by far the best. My mood swings are minimal and my breasts aren't sore at all. The only slight side effect is that I get menstrual headaches, but that's something I can live with.
5Patient Review
10/19/2012
Lo/Ovral-28 for Birth Control
I've been using this for 26 years with no side effects or pregnancies.
5Patient Review
1/19/2016
Lo/Ovral-28 for Endometriosis
I've been using this birth control for years, and it's the only one I ever want to use. It cleared my acne, though I did gain some weight while on it. Overall, highly recommend!
5Patient Review
9/14/2011
Lo/Ovral-28 for Birth Control
I've been taking this pill for over 15 years with no problems whatsoever. So when I was switched to Levora, imagine my dismay at the host of issues that presented themselves--including a drastic decrease in sex drive. I'm coming back to what works before Levora destroys everything.
5Patient Review
4/20/2012
Lo/Ovral-28 for Endometriosis
This is the best birth control I've tried for my extremely painful periods and endometriosis. It's been a total life-saver! The only downside is that I sometimes get menstrual headaches, but that's much preferable to the alternative.
5Patient Review
10/19/2012
Lo/Ovral-28 for Birth Control
I've been taking this treatment for 26 years with no side effects and no pregnancies.
5Patient Review
1/19/2016
Lo/Ovral-28 for Endometriosis
I've been using this birth control for years and it's really great. I tried Nexplanon for a while but ended up getting it taken out and switching back to this. I highly recommend it - it's cleared my acne, and though I did gain some weight while taking it (I don't think that was entirely the pill's fault, though) bottom line is that I love it.
4.3Patient Review
11/3/2013
Lo/Ovral-28 for Birth Control
This birth control has been great for me and my boyfriend. It's regulated my periods and we haven't gotten pregnant. As long as you're consistent with taking the pills, this should work well for you too. I advise setting an alarm to remind you to take them every day, especially if you have a busy school schedule like I do. Overall, I'm very satisfied with this form of contraception.
4.3Patient Review
11/3/2013
Lo/Ovral-28 for Birth Control
Lo Ovral has been a great addition to my life for the past eight months. It's helped regulate my periods and I haven't gotten pregnant, which is amazing. As long as you're consistent with taking the pill every day and setting an alarm, it should work well for you too!
3.3Patient Review
7/25/2011
Lo/Ovral-28 for Birth Control
I experienced some chest pain on my left side, as well as some pretty severe headaches. I also had a lot of stomach pain and felt generally cranky.
3.3Patient Review
7/25/2011
Lo/Ovral-28 for Birth Control
I experienced chest pains on my left side, as well as headaches and stomach pain. I was also feeling very cranky.
3Patient Review
6/18/2017
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I've only been on this pill for a week, but I'm wondering if anyone else has had the same issues I have. For over a year now, I've had severely heavy bleeding and bad cramps. The past two days especially, I've had zero energy and my belly has swollen a lot. Again, I know it's early yet, but I just wanted to see if anyone else out there has experienced anything similar.
3Patient Review
9/18/2022
Lo/Ovral-28 for Painful Periods
I experienced some pretty severe side effects while taking this medication, but fortunately they subsided and I'm feeling better now.
3Patient Review
6/18/2017
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I've only been on this pill for a week, but I'm wondering if anyone else has experienced the same issues I have. For context, I'm 48 years old and have been dealing with heavy bleeding for over a year. The last two days in particular, I've had awful cramps and zero energy. My belly has also swollen quite a bit. Again, I know it's early days yet, but I just wanted to check in and see if others have had similar experiences starting out on this medication.
3Patient Review
9/18/2022
Lo/Ovral-28 for Painful Periods
The side effects were really intense, but I'm feeling better now. I'm still taking the medication.
2.3Patient Review
2/27/2012
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I just finished the pack and I am really unhappy with how it made me feel. Stomach aches, weight gain, breakthrough bleeding, and constant depression caused me a lot of grief. My husband tried to be supportive but even he couldn't handle it. I would not recommend this to anyone.
2.3Patient Review
8/3/2013
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I've only been on this pill for one month, and in that time I have had constant heavy bleeding (which is abnormal), awful mood swings, and a contant pain that wakes me up at night. Sometimes the pain is so severe I cry. I would not recommend this to anyone!
2.3Patient Review
2/27/2012
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I just finished the pack and I am not happy with the results. Stomach pain, weight gain, breakthrough bleeding, and increased depression are not what I was hoping for. My husband has been supportive but even he is struggling to understand how I'm feeling.
2.3Patient Review
8/3/2013
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I have only been on this pill for a month, and in that time I have had abnormal heavy bleeding, awful mood swings, and constant pain that has interrupted my sleep. I would not recommend this to anyone!
2Patient Review
12/2/2011
Lo/Ovral-28 for Birth Control
I got pregnant while taking this birth control, which is clearly not effective. I was also not pregnant for the eight months before I started taking it again.
2Patient Review
12/2/2011
Lo/Ovral-28 for Birth Control
I got pregnant after taking this birth control for only four months. I had been using it consistently and correctly, too. This is really frustrating because I was off the pill for eight months before that without any issue.
1.7Patient Review
8/29/2011
Lo/Ovral-28 for Painful Periods
I've been taking this for seven months now, and I absolutely despise it. Not only does it not help with my regularity or pain, but it also turned me into a pizza face thanks to the high amount of testosterone in the medication. I would have never known if the pharmacist hadn't told me; so be warned if you're considering this treatment.
1.7Patient Review
8/29/2011
Lo/Ovral-28 for Painful Periods
I've been taking this for seven months now and I absolutely despise it. I was prescribed it by my gynecologist for spotting, but didn't know (until the pharmacist told me) that it contains such a high amount of testosterone that it gave me cystic acne. It was awful and made me really miserable.
1Patient Review
11/4/2018
Lo/Ovral-28 for Birth Control
I became pregnant while taking Lo Ovral about a year into my use of the oral contraceptive. My child is now 10 years old. I had such negative experiences with this drug that I vowed to never take another oral contraceptive again.
1Patient Review
4/17/2014
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I would not recommend this birth control to anyone. I was placed on it to help regulate my period, but after two weeks of use I'm still bleeding and dealing with huge clots. Side effects have been nausea and severe cramps on top of the pain I already have.
1Patient Review
4/17/2014
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I would not recommend this birth control to anyone. I was placed on it to help regulate my period, but it's only made things worse. I've been bleeding constantly and have had huge clots. On top of that, the side effects have been awful: nausea and severe cramps.
1Patient Review
11/4/2018
Lo/Ovral-28 for Birth Control
I was on Lo Ovral for about a year when I became pregnant. My child is now 10years. I will never take another oral contraceptive based solely on my experience with this one.

Patient Q&A Section about lo/ovral-28

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of birth control is Lo Ovral?

"This contraceptive contains both norgestrel, a progestational compound, and ethinyl estradiol, an estrogenic compound."

Answered by AI

Is Lo Ovral still available?

"is the last date that the Lo/Ovral brand name will be used in the United States. If the Food and Drug Administration has approved generic versions of this product, then there may be generic equivalents available."

Answered by AI

Can Ovral 28 stop periods?

"Some women may miss periods or have light periods while taking Ovral 28 Tablet, even if they are not pregnant. If you think you are pregnant or have missed one or two periods, contact your doctor. This may happen if you are not taking Ovral 28 Tablet at the same time every day."

Answered by AI

Clinical Trials for Lo/Ovral-28

Image of University of California, San Diego in La Jolla, United States.

Lidocaine for Pain Control in Birth Control

18 - 50
Female
La Jolla, CA
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying participants opinions of their clinicians' empathy. The investigators are inviting patients who arrive at their clinic visit seeking an IUD. Usually, at University of California, San Diego (UCSD), for patients who have never delivered a baby, clinicians use a buffered paracervical block for before IUD placement. The purpose of this research study is to investigate whether a "buffered" (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) paracervical block (numbing medication given on both sides of the cervix) is effective in reducing pain during IUD placement in individuals with prior C-sections, the difference between buffered and unbuffered for nulliparous patients, and whether a medicated gel reduces pain with the paracervical block.
Recruiting
Paid Trial
University of California, San DiegoSheila K Mody, MD, MPH
Image of EmpoweRx, Inc in Del Mar, United States.

HAPPI Software for Birth Control Access

18+
All Sexes
Del Mar, CA
The goal of this clinical trial is to learn if use of the HAPPI software can improve pharmacist-provided birth control services. The main questions it aims to answer are: 1. Does the HAPPI software make it easier for pharmacists to provide birth control services in their pharmacy? 2. Does the HAPPI software make it easier for patients to access birth control? Researchers will compare pharmacists' implementation and patients' access when using the HAPPI software and when not using the HAPPI software to see if the software improves implementation and access. Participants will include pharmacists and patients. Pharmacists will be asked to provide birth control services as normal while using the HAPPI software. Patients will be asked to receive birth control services from a pharmacist as normal, while using the HAPPI software.
Recruiting
Has No Placebo
EmpoweRx, Inc
Image of Calabasas Pharmacy in Calabasas, United States.

Electronic Health Record Platform for Birth Control

18 - 51
Female
Calabasas, CA
Hormonal contraceptives are medications that require a prescription, traditionally from a physician or advanced practice provider. Over the past decade, pharmacists have gained the authority to prescribe contraceptives in many states, allowing patients to access these medications directly in pharmacies without first seeing another healthcare provider. The Pharmacist Resource to Implement Services as Modules (PRISM) is an Electronic Health Record platform designed to streamline workflows and provide clinical decision support, making it easier and safer to deliver clinical services in community pharmacies. This pilot study will evaluate patient-reported outcomes for women receiving contraceptive services from pharmacists using the PRISM platform at five community pharmacies across the United States over a 12-week period. The study will assess the quality of care, contraception continuation and failure rates, side effect rates, preventative healthcare utilization, and overall patient experience with pharmacy contraceptive services.
Waitlist Available
Has No Placebo
Calabasas Pharmacy (+4 Sites)OvaryIt, LLC
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Image of Jackson State University/Department of Behavioral & Environmental Health in Jackson, United States.

PEN-3 Intervention for Postpartum Depression

18 - 45
Female
Jackson, MS
Maternal mortality in the United States is higher than in peer nations and has not decreased since 1990. Beyond mortality, severe maternal mortality impacts far too many women. Not only are these high rates alarming, but notable racial/ethnic and socioeconomic disparities exist. These inequities are highly regional, with women living in the rural southeast part of the United States, including the Mississippi Delta, having the highest rates of maternal mortality and morbidity. Unfortunately, these disparities have proven to be stubbornly resistant to interventions, necessitating an innovative multifaceted approach focused on community practice, building trust, and prioritizing patient voices. To meet this need, this proposal aims to establish the Mississippi Delta Research Center of Excellence for Maternal Health with the goal of addressing preventable maternal mortality, decreasing severe maternal morbidity, and promoting maternal health equity in partnership with the Mississippi Delta community. This patient-clinical linkages intervention study will evaluate the effectiveness of a multilevel and multisector communication and health literacy strategy to increase trust and engagement in postpartum healthcare among women in the Mississippi Delta, with a specific focus on Black women, their families, and their communities. These research projects both have the overarching goal of partnering with the community to determine and meet the needs of pregnant and postpartum women in the Mississippi Delta and address the disparities within maternity health and health care outcomes.
Recruiting
Has No Placebo
Jackson State University/Department of Behavioral & Environmental HealthMary Shaw, PhD
Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Birth Control Pills and DNA Interaction

18 - 45
Female
Aurora, CO
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these birth control pills work to prevent pregnancy. The investigators are also interested in exploring how these differences in our DNA can also explain why patients taking the exact same formulation of birth control pill will experience very different side effects. The main questions it aims to answer are: * Do individuals with the CYP3A7\*1C variant have increased metabolism of both desogestrel and ethinyl estradiol when taking a combined oral contraceptive pill? * Do individuals with the CYP3A7\*1C variant experience higher rates of breakthrough ovulation while taking a desogestrel/ethinyl estradiol combined oral contraceptive pill? * What novel genetic loci are associated with alterations in steroid hormone pharmacokinetics and pharmacodynamics among a larger cohort of combined oral contraceptive pill users? Participants will take a specific formulation of combined oral contraceptive pill (desogestrel/ethinyl estradiol) and undergo the following procedures: * Blood draw to measure the amount of progestin and estrogen in their system from the combined oral contraceptive pill * Questionnaires to assess side effects possibly caused by the combined oral contraceptive pill * Blood draw to measure endogenous hormone levels and biomarkers that may be affected by the combined oral contraceptive pill * A transvaginal ultrasound to measure any ovarian follicles (optional procedure)
Phase 4
Recruiting
University of Colorado Anschutz Medical Campus (+2 Sites)Aaron M Lazorwitz, MD, PhD
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Image of Greater Boston Health Center in Boston, United States.

SBIRT for Alcohol and Substance Use Disorders

18+
All Sexes
Boston, MA
The goal of this clinical trial is to test the effectiveness of evidence-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) among adult patients who screen positive to one or more risky alcohol or substance use behaviors while seeking care at a sexual and reproductive health (SRH) clinic. The main questions it aims to answer are: * Does SBIRT impact patients' alcohol and substance use, SRH, mental health, physical health, quality of life, and wellbeing? * Does SBIRT effectiveness differ by ethnicity, socioeconomic status, age, gender, and urbanicity? * Does SBIRT effectiveness differ by delivery mode (in-person vs. telemedicine)? Participants will receive in-person and telemedicine SBIRT, or usual care. Participants will complete surveys at interviews at baseline, 30 days, and 3 months. Researchers will compare patients who received SBIRT to patients who receive usual care to see if patients who receive the SBIRT intervention have a greater reduction in negative outcomes as compared to those who receive usual care. In this setting, usual care consists of basic quantity and frequency questions asked inconsistently as part of the admission process and varying by provider, with no standardized approach to screening, treatment, follow-up, or referral.
Recruiting
Has No Placebo
Greater Boston Health Center (+3 Sites)Kelli S Hall, MD
Image of OHSU in Portland, United States.

Progestin Contraceptives for Birth Control Effects

18 - 40
Female
Portland, OR
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first year of progestin contraception use. Participants will choose to receive the contraceptive implant (Etonogestrel implant also called Nexplanon) or the contraceptive injectable (Depo-medroxyprogesterone acetate (DMPA) also called Depo-Provera) for up to 12 months. They will be asked to have 4 endometrial biopsies over the course of the study, as well as blood draws, physical exams, and pregnancy tests. Participants will also use a daily text message or email diary to report bleeding patterns. This study's plan is to comprehensively phenotype bleeding patterns and profile the entire endometrium using single-cell RNA seq data (sCRNAseq).
Phase < 1
Recruiting
OHSUAlison Edelman, MD
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