Lo/Ovral-28

Birth Control, Acne Vulgaris, Folate supplementation therapy + 5 more
Treatment
1 FDA approval
20 Active Studies for Lo/Ovral-28

What is Lo/Ovral-28

EthinylestradiolThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic hormone developed in 1938 that has greater absorption into the body when taken by mouth compared to other forms of estrogen. It is used in many contraceptives and was approved by the FDA in 1943.
LOESTRIN Fe 1.5/30is the brand name
image of different drug pills on a surface
Lo/Ovral-28 Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679

Approved as Treatment by the FDA

Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .
Birth Control
Used to treat Contraception in combination with Levonorgestrel

Effectiveness

How Lo/Ovral-28 Affects PatientsEthinylestradiol is a type of synthetic estrogen that helps to prevent ovulation by decreasing hormones in the body. It is safe to take once per day, and the risk of serious side effects from an overdose are low. However, patients should be aware of the increased risk of blood clotting associated with this drug.
How Lo/Ovral-28 works in the bodyEthinylestradiol is a synthetic hormone used in some contraceptive pills. It works by making the mucus in the cervix thicker, preventing sperm from entering the uterus. It also suppresses the hormones that normally trigger ovulation. Additionally, it reduces blood flow to the endometrium, making it harder for a fertilized egg to implant. Finally, it increases the amount of a protein that binds to hormones, making them less effective in the body.

When to interrupt dosage

The measure of Lo/Ovral-28 relies upon the diagnosed state, including Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The sum of dosage is contingent upon the method of administration detailed in the table below.
Condition
Dosage
Administration
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Mild to Moderate Acne
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopausal Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral

Warnings

Lo/Ovral-28 has twenty-six contraindications and should not be employed in cases of the conditions provided in the following table.Lo/Ovral-28 Contraindications
Condition
Risk Level
Notes
Heavy Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
Breast
Do Not Combine
Impaired Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
There are 20 known major drug interactions with Lo/Ovral-28.
Common Lo/Ovral-28 Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Lo/Ovral-28 Toxicity & Overdose RiskWomen overdosing on estrogen may experience bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment for this type of overdose should include addressing symptoms, monitoring for potassium and sodium levels, and checking for signs of metabolic acidosis.
image of a doctor in a lab doing drug, clinical research

Lo/Ovral-28 Novel Uses: Which Conditions Have a Clinical Trial Featuring Lo/Ovral-28?

38 active trials are presently examining the utility of Lo/Ovral-28 to furnish Folate supplementation therapy, ameliorate Premenstrual Dysphoric Disorder and reduce the symptoms of Menopause.
Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Patient desires oral contraception for birth control
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Menopause
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting

Lo/Ovral-28 Reviews: What are patients saying about Lo/Ovral-28?

5Patient Review
9/14/2011
Lo/Ovral-28 for Birth Control
I've been on this pill for over 15 years without any issues. Unfortunately, the clinic I was going to stopped carrying it and switched me to Levora. I had nothing but problems with Levora, including a decreased sex drive. I'm coming back to this pill before Levora ruins my relationship.
5Patient Review
4/20/2012
Lo/Ovral-28 for Endometriosis
This medication has been a total life-saver for me. I have long, painful periods as well as endometriosis, so being on birth control is a must for me. I've tried several different kinds and this one is by far the best. My mood swings are minimal and my breasts aren't sore at all. The only slight side effect is that I get menstrual headaches, but that's something I can live with.
5Patient Review
10/19/2012
Lo/Ovral-28 for Birth Control
I've been using this for 26 years with no side effects or pregnancies.
5Patient Review
1/19/2016
Lo/Ovral-28 for Endometriosis
I've been using this birth control for years, and it's the only one I ever want to use. It cleared my acne, though I did gain some weight while on it. Overall, highly recommend!
5Patient Review
9/14/2011
Lo/Ovral-28 for Birth Control
I've been taking this pill for over 15 years with no problems whatsoever. So when I was switched to Levora, imagine my dismay at the host of issues that presented themselves--including a drastic decrease in sex drive. I'm coming back to what works before Levora destroys everything.
5Patient Review
4/20/2012
Lo/Ovral-28 for Endometriosis
This is the best birth control I've tried for my extremely painful periods and endometriosis. It's been a total life-saver! The only downside is that I sometimes get menstrual headaches, but that's much preferable to the alternative.
5Patient Review
10/19/2012
Lo/Ovral-28 for Birth Control
I've been taking this treatment for 26 years with no side effects and no pregnancies.
5Patient Review
1/19/2016
Lo/Ovral-28 for Endometriosis
I've been using this birth control for years and it's really great. I tried Nexplanon for a while but ended up getting it taken out and switching back to this. I highly recommend it - it's cleared my acne, and though I did gain some weight while taking it (I don't think that was entirely the pill's fault, though) bottom line is that I love it.
4.3Patient Review
11/3/2013
Lo/Ovral-28 for Birth Control
This birth control has been great for me and my boyfriend. It's regulated my periods and we haven't gotten pregnant. As long as you're consistent with taking the pills, this should work well for you too. I advise setting an alarm to remind you to take them every day, especially if you have a busy school schedule like I do. Overall, I'm very satisfied with this form of contraception.
4.3Patient Review
11/3/2013
Lo/Ovral-28 for Birth Control
Lo Ovral has been a great addition to my life for the past eight months. It's helped regulate my periods and I haven't gotten pregnant, which is amazing. As long as you're consistent with taking the pill every day and setting an alarm, it should work well for you too!
3.3Patient Review
7/25/2011
Lo/Ovral-28 for Birth Control
I experienced some chest pain on my left side, as well as some pretty severe headaches. I also had a lot of stomach pain and felt generally cranky.
3.3Patient Review
7/25/2011
Lo/Ovral-28 for Birth Control
I experienced chest pains on my left side, as well as headaches and stomach pain. I was also feeling very cranky.
3Patient Review
6/18/2017
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I've only been on this pill for a week, but I'm wondering if anyone else has had the same issues I have. For over a year now, I've had severely heavy bleeding and bad cramps. The past two days especially, I've had zero energy and my belly has swollen a lot. Again, I know it's early yet, but I just wanted to see if anyone else out there has experienced anything similar.
3Patient Review
9/18/2022
Lo/Ovral-28 for Painful Periods
I experienced some pretty severe side effects while taking this medication, but fortunately they subsided and I'm feeling better now.
3Patient Review
6/18/2017
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I've only been on this pill for a week, but I'm wondering if anyone else has experienced the same issues I have. For context, I'm 48 years old and have been dealing with heavy bleeding for over a year. The last two days in particular, I've had awful cramps and zero energy. My belly has also swollen quite a bit. Again, I know it's early days yet, but I just wanted to check in and see if others have had similar experiences starting out on this medication.
3Patient Review
9/18/2022
Lo/Ovral-28 for Painful Periods
The side effects were really intense, but I'm feeling better now. I'm still taking the medication.
2.3Patient Review
2/27/2012
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I just finished the pack and I am really unhappy with how it made me feel. Stomach aches, weight gain, breakthrough bleeding, and constant depression caused me a lot of grief. My husband tried to be supportive but even he couldn't handle it. I would not recommend this to anyone.
2.3Patient Review
8/3/2013
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I've only been on this pill for one month, and in that time I have had constant heavy bleeding (which is abnormal), awful mood swings, and a contant pain that wakes me up at night. Sometimes the pain is so severe I cry. I would not recommend this to anyone!
2.3Patient Review
2/27/2012
Lo/Ovral-28 for Abnormally Long or Heavy Periods
I just finished the pack and I am not happy with the results. Stomach pain, weight gain, breakthrough bleeding, and increased depression are not what I was hoping for. My husband has been supportive but even he is struggling to understand how I'm feeling.
2.3Patient Review
8/3/2013
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I have only been on this pill for a month, and in that time I have had abnormal heavy bleeding, awful mood swings, and constant pain that has interrupted my sleep. I would not recommend this to anyone!
2Patient Review
12/2/2011
Lo/Ovral-28 for Birth Control
I got pregnant while taking this birth control, which is clearly not effective. I was also not pregnant for the eight months before I started taking it again.
2Patient Review
12/2/2011
Lo/Ovral-28 for Birth Control
I got pregnant after taking this birth control for only four months. I had been using it consistently and correctly, too. This is really frustrating because I was off the pill for eight months before that without any issue.
1.7Patient Review
8/29/2011
Lo/Ovral-28 for Painful Periods
I've been taking this for seven months now, and I absolutely despise it. Not only does it not help with my regularity or pain, but it also turned me into a pizza face thanks to the high amount of testosterone in the medication. I would have never known if the pharmacist hadn't told me; so be warned if you're considering this treatment.
1.7Patient Review
8/29/2011
Lo/Ovral-28 for Painful Periods
I've been taking this for seven months now and I absolutely despise it. I was prescribed it by my gynecologist for spotting, but didn't know (until the pharmacist told me) that it contains such a high amount of testosterone that it gave me cystic acne. It was awful and made me really miserable.
1Patient Review
11/4/2018
Lo/Ovral-28 for Birth Control
I became pregnant while taking Lo Ovral about a year into my use of the oral contraceptive. My child is now 10 years old. I had such negative experiences with this drug that I vowed to never take another oral contraceptive again.
1Patient Review
4/17/2014
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I would not recommend this birth control to anyone. I was placed on it to help regulate my period, but after two weeks of use I'm still bleeding and dealing with huge clots. Side effects have been nausea and severe cramps on top of the pain I already have.
1Patient Review
4/17/2014
Lo/Ovral-28 for Abnormal Bleeding from the Uterus
I would not recommend this birth control to anyone. I was placed on it to help regulate my period, but it's only made things worse. I've been bleeding constantly and have had huge clots. On top of that, the side effects have been awful: nausea and severe cramps.
1Patient Review
11/4/2018
Lo/Ovral-28 for Birth Control
I was on Lo Ovral for about a year when I became pregnant. My child is now 10years. I will never take another oral contraceptive based solely on my experience with this one.

Patient Q&A Section about lo/ovral-28

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of birth control is Lo Ovral?

"This contraceptive contains both norgestrel, a progestational compound, and ethinyl estradiol, an estrogenic compound."

Answered by AI

Is Lo Ovral still available?

"is the last date that the Lo/Ovral brand name will be used in the United States. If the Food and Drug Administration has approved generic versions of this product, then there may be generic equivalents available."

Answered by AI

Can Ovral 28 stop periods?

"Some women may miss periods or have light periods while taking Ovral 28 Tablet, even if they are not pregnant. If you think you are pregnant or have missed one or two periods, contact your doctor. This may happen if you are not taking Ovral 28 Tablet at the same time every day."

Answered by AI

Clinical Trials for Lo/Ovral-28

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Have you considered Lo/Ovral-28 clinical trials? We made a collection of clinical trials featuring Lo/Ovral-28, we think they might fit your search criteria.
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