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MRI Neurofeedback for Enhancing Motivation

N/A

Recruiting

Led By R. Alison Adock, MD, PhD

Research Sponsored by Duke University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during the mri scan, approximately 2 hours

Awards & highlights

Study Summary

This trial looks at how healthy people use their brains to stay motivated, using MRI scans to observe brain activity.

Who is the study for?

This trial is for healthy right-handed individuals aged 18-45 who use effective birth control if of childbearing capacity. It's not suitable for those with psychiatric medication use in the past six months, serious medical conditions, certain neurological disorders, metal implants, claustrophobia, or a weight over 250 pounds.Check my eligibility

What is being tested?

The study aims to understand self-regulation of motivation by providing participants with real-time feedback on their brain activity using MRI technology focused on a specific area related to dopamine production.See study design

What are the potential side effects?

There are generally no side effects associated with participating in an MRI-based study. However, some individuals may experience discomfort due to the confined space of the MRI scanner or from lying still for extended periods.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during the mri scan, approximately 2 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during the mri scan, approximately 2 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and during the mri scan, approximately 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Percent signal change in VTA BOLD activation

Secondary outcome measures

Change in effort-based decision making, as measured by the Effort Expenditure for Reward Task (EEfRT)

Change in motivated memory, as measured by the Monetary Incentive Encoding task (MIE)

Trial Design

3Treatment groups

Experimental Treatment

Group I: Intentional Versus Cue-Evoked Midbrain ActivationExperimental Treatment1 Intervention

Participants meeting study inclusion will be scheduled for two sessions: one baseline behavioral visit and an fMRI session to assess the ability to self-stimulate VTA activation. Session one will include a battery of cognitive assessments and a demonstration of the reward-based learning task in session two. The experimental imaging task session will be done within one week of session one. Participants will been randomly split into two group: group one will complete a reward-based learning task before the VTA activation task and group two will complete reward task after VTA activation. During the VTA activation task, participants will be instructed to achieve a heightened state of motivation using personally relevant thoughts and imagery.

Group II: Intentional Midbrain Activation Effects on Motivated MemoryExperimental Treatment1 Intervention

Participants will take part in four sessions: visit 1-baseline + memory encoding, visit 2-memory retrieval, visit 3-memory encoding, visit 4-memory retrieval). Encoding and retrieval of the memoranda will occur 24 hours apart. Study visits will take place no more than 7 days apart. One group of participants will complete all sessions at the Center for Cognitive Neuroscience. The remainder of participants will complete the encoding sessions in the MRI machine, .

Group III: Intentional Midbrain Activation Effects on Effort-Based Decision MakingExperimental Treatment1 Intervention

Participants will be randomly assigned to an MRI group or a behavioral control group. All participants will complete an effort-based learning task and a series of questionnaires in session one. Session two may include an MRI based on group assignment. Participants in the MRI group will complete the VTA activation task. Following, they will complete the effort task and questionnaires a second time. The behavioral control group will complete a second session consisting of the effort task and questionnaires.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Duke UniversityLead Sponsor

2,364 Previous Clinical Trials

3,420,452 Total Patients Enrolled

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,519 Total Patients Enrolled

R. Alison Adock, MD, PhDPrincipal InvestigatorDuke University

Media Library

Intentional Midbrain Activation Effects on Motivated Memory Clinical Trial Eligibility Overview. Trial Name: NCT05929898 — N/A

Self-Regulation Research Study Groups: Intentional Midbrain Activation Effects on Motivated Memory, Intentional Versus Cue-Evoked Midbrain Activation, Intentional Midbrain Activation Effects on Effort-Based Decision Making

Self-Regulation Clinical Trial 2023: Intentional Midbrain Activation Effects on Motivated Memory Highlights & Side Effects. Trial Name: NCT05929898 — N/A

Intentional Midbrain Activation Effects on Motivated Memory 2023 Treatment Timeline for Medical Study. Trial Name: NCT05929898 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research recruiting participants aged 75 or older?

"According to the study's guidelines, candidates must fall between the ages of 18 and 45 in order to be considered for inclusion."

Answered by AI

Is entry to this experiment accessible for participants at present?

"Affirmative. The information on clinicaltrials.gov asserts that this trial is actively seeking participants, with the original post being dated July 30th 2023 and most recent update occurring August 4th of the same year. A total of 190 individuals are required for this study at a single site"

Answered by AI

What type of participants is this clinical trial looking to recruit?

"This medical trial is accepting 190 eligible applicants, aged between 18 and 45, who have the drive to participate. Further requirements include: gender (male or female), right-handedness, overall good health for all participants; women of childbearing age must also use a reliable form of contraception."

Answered by AI

How many individuals have enrolled in this trial?

"Affirmative. Per the information hosted on clinicaltrials.gov, sign-ups are currently open for this medical experiment which was initially posted on July 30th 2023 and last modified on August 4th 2023. A total of 190 patients must be recruited from a single location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants

2023. "MRI Neurofeedback and Brain Circuits Related to Motivation in Healthy Participants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05929898.