This trial is evaluating whether Folic Acid Tablet will improve 2 primary outcomes and 8 secondary outcomes in patients with Breast Cancer. Measurement will happen over the course of Up to approximately 2 years.
This trial requires 75 total participants across 2 different treatment groups
This trial involves 2 different treatments. Folic Acid Tablet is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 & 3 and have had some early promising results.
"The most common treatment is increased dietary intake of folate to prevent megaloblastic anemia. Occasionally, vitamin B6 supplementation is used. While there are several other treatments for megaloblastic anemia, none is as commonly prescribed as folic acid." - Anonymous Online Contributor
"About 10% of United States female teens, and almost 0.9% of high school girls are folic acid deficient. This is in contrast to many other countries." - Anonymous Online Contributor
"There is tentative evidence that the risk for neural tube defects may be reduced with a supplement of 100 μg to 1 mg of folic acid in women of child-bearing age who have a history of neural tube defects, but there is insufficient evidence for vitamin B6 supplementation. We are unable to reach a conclusive conclusion as to whether there are any long term effects of supplementation. Until further research is completed, folic acid supplements should only be recommended for young or adolescent women, or for women who do not get a daily dose of folic acid, rather than solely for women who have a history of a neural tube defect." - Anonymous Online Contributor
"Signs of folate deficiency included poor balance, fatigue, and trouble thinking. These physical signs can affect a person's health if left untreated. The main treatment and management of folic acid deficiency is supplementation with folic acid or folate-rich foods. In women of childbearing potential supplemental folic acid and folate in vitamin supplements are recommended. Folic acid deficiency is much more common than previously thought with an incidence of 2.7% in the UK. Screening is needed to identify those who may have the condition and who should be treated. There is strong evidence that treatment of deficiencies during pregnancy can decrease the occurrence of spastic birth in infancy and reduce the chances of neural tube defects." - Anonymous Online Contributor
"The development of deficiency involves environmental and nutritional factors. Folate insufficiency is prevalent both in the urban and the rural populations with a high risk of deficiency." - Anonymous Online Contributor
"Folate refers to a group of water-soluble molecules that are used for the metabolism of other molecules. They are particularly important for cells that take their energy from dividing fast (i.e. proliferative cells), such as red blood cells (erythrocytes) and germline and somatic cells of multicellular organisms, including humans. In healthy people, the quantity of folate in the bloodstream is sufficient to meet the organism's daily needs. However, if folate is not provided as a dietary component some of the necessary molecules may not be available, causing symptoms within the affected population. These include defects in cellular division, development and functioning, or even cancer, as in the case of folate deficiency." - Anonymous Online Contributor
"[There are no new treatments for folic acid deficiency. Many treatments for folate deficiency have been used since the 1940s.. To find an folic acid deficiency clinical trial near you, please visit [Power (www.withpower.com/d/folic-acid-deficiency-treatments-cluster)." - Anonymous Online Contributor
"There is a decrease in plasma homocysteine concentration after the consumption of 1 mg of folic acid/day, which can explain the lack of effect on venous thromboembolism incidence after 2 years of therapy. The lower plasma concentrations of folic acid after the consumption of folic acid can be explained through an increase in deoxyribonucleotide excretion and higher plasma concentrations of folic acid related to folic acid deficiency. Both of these mechanisms can be treated with high doses of folic acid supplementation." - Anonymous Online Contributor
"For most of us, the concept of a deficiency of folate, or of the vitamins that it co-ordinates, seems highly unlikely. However, folate deficiency can be a problem for people, particularly in pregnancy, and, when not remedied by folate supplementation, it can be fatal. Folic acid supplements are available in many countries and should be made available to pregnant women in developing countries. Vitamin B deficiency should also be prevented. It is likely that the [B-complex vitamins, folic acid, vitamin B and vitamins B and E may be effective for some disease states such as cancer and coronary heart disease (CHD), but it is unclear whether they affect the rate of progression of the disease." - Anonymous Online Contributor
"So far, there are no clinical trials demonstrating that folic acid is effective in the treatment of FMD. Although we have made many suggestions, we still need more research on this subject. It still needs to be demonstrated whether folic acid could be one of the first choices of therapy in people with peripheral neuropathy due to FMD." - Anonymous Online Contributor
"Most common side effects of folic acid tablet are diarrhea, dizziness, dry mouth, and nausea. Symptoms of folate depletion usually resolve after withdrawing folic acid tablet." - Anonymous Online Contributor
"The most common manifestations of deficiencies and abnormalities were anemia (62%), increased red cell distribution width (23%), leukocytosis (23%), and thrombocytosis (12%); and these manifestations were not different between groups. Data from a recent study do not explain the effects of folic acid on the incidence of neural tube defects and the effects of low folic acid on plasma homocysteine. The presence of anemia or other blood abnormalities does not exclude folate deficiency. Folic acid should be studied as a cause of anemia and other blood dysfunctions." - Anonymous Online Contributor