Machine Perfusion for Liver Transplant Preservation
What You Need to Know Before You Apply
What is the purpose of this trial?
Hypothermic machine perfusion (HMP) has been shown to be beneficial to preserve extended criteria donor (ECD) livers for transplantation. Normothermic machine perfusion (NMP) had the same benefits and also the convenience on liver quality assessment. The investigators proposed to do sequential HMP (1-4 hours) and NMP (1-14 hours) on 18 ECD transplanted human livers by using an institutional-developed perfusion device for liver transplantation.
Who Is on the Research Team?
Koji Hashimoto, MD, PhD
Principal Investigator
The Cleveland Clinic
Are You a Good Fit for This Trial?
This trial is for adults aged 18 or older who are undergoing liver transplantation and can follow the study's procedures. They must understand and sign a consent form. It's not open to those who don't speak the language well, have mental incapacities, need multiple organ transplants, or are receiving partial grafts.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Ex Vivo Organ Preservation
Liver grafts are preserved using hypothermic and normothermic machine perfusion with continuous oxygen supply
Transplantation and Immediate Post-Transplant Care
Liver transplantation procedure followed by immediate post-transplant care according to clinical standards
Follow-up
Participants are monitored for safety and effectiveness after transplantation
What Are the Treatments Tested in This Trial?
Interventions
- Sequential Hypo- and Normo-thermic Perfusion
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Cleveland Clinic
Lead Sponsor
Koji Hashimoto
Lead Sponsor