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SABR for Oligometastatic Cancer (SABR-COMET-3 Trial)
SABR-COMET-3 Trial Summary
This trial will compare the effectiveness of a new radiation therapy technique called SABR to the current standard of care for treating people with cancer that has spread to other parts of the body.
SABR-COMET-3 Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSABR-COMET-3 Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.SABR-COMET-3 Trial Design
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Who is running the clinical trial?
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- I need surgery to fix a bone in my thigh.I've had a brain scan within the last 8 weeks to check for cancer spread.I have or had a tumor close to my spinal cord, but if removed, it's part of my 8 lifetime metastases limit.My primary cancer is under control.I currently have 1 to 3 cancer spread sites and no more than 8 in my lifetime.You are expected to live for at least 6 more months.I am 18 years old or older.I've had a physical exam and my activity level checked within the last 6 weeks.I am 18 years old or older.My original cancer has been stable for at least 3 months after treatment.My cancer has spread, and this was confirmed by tests.I need surgery to relieve pressure in my brain from cancer spread.You agree to give permission to participate in the study after understanding the information provided.Not all areas of my cancer can be treated.I have not used chemotherapy drugs 2 weeks before to 1 week after my specific radiation treatment.I have 1 to 3 current cancer spread sites and no more than 8 in my lifetime.My cancer cannot be removed by surgery or I chose not to have surgery.I cannot have radiotherapy due to serious health conditions like lung disease, Crohn's, lupus, or scleroderma.I can stay still during treatments.I have had liver problems in the past.I have had issues with my lung function in the past.I have had radiation before, but it doesn't heavily overlap with the area to be treated now.I am able to get out of my bed or chair and move around.I have fluid buildup due to cancer in the lining of my lung.I've had a CT or PET-CT scan of my chest, abdomen, and pelvis within the last 8 weeks.I've had a bone scan within 8 weeks before joining, or 12 weeks if getting SABR.My cancer outside the brain has lesions no larger than 5 cm, except for some bone metastases.I am a woman who can have children and have a negative pregnancy test within the last 4 weeks.I have not had cancer in the last 5 years, except for non-melanoma skin cancer.I have a brain tumor larger than 3 cm or total brain tumors over 30 cc in volume.I've had specific scans within 8 weeks before joining the trial due to an unbiopsied lung nodule.I've had a PET scan within 8 weeks before joining the study due to uncertain imaging and rising cancer markers.It's been 3 months since my original cancer treatment, with no growth at the cancer's original location.I can use devices needed for my radiation treatment without discomfort.I am able to get out of my bed or chair and move around.My cancer has spread, and this was confirmed by tests.You are expected to live for at least 6 more months.
- Group 1: Standard of Care Treatment (Arm 1)
- Group 2: Stereotactic Arm (Arm 2)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many distinct locations is this clinical experiment being handled in?
"Participants can join this research trial at BC Cancer - Prince George, Kelowna (BC), Walker Family Cancer Centre in Saint Catharines (NS) as well as 9 other medical centres."
Is there room to accommodate further participants in this experiment?
"Clinicaltrials.gov affirms that this medical trial is accepting participants, with the initial advertisement posted on November 1st 2019 and most recently updated June 28th 2022."
How many individuals are actively engaged in this investigative endeavor?
"A total of 330 participants, who satisfy the listed qualifications, are needed to successfully complete this trial. Patients can opt-in at either BC Cancer - Prince George in Prince George or BC Cancer in Kelowna."
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
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