Platelet Rich Fibrin for Tooth Abscess

(EMS Trial)

Overseen By Michael Skanchy, DMD

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: Mark Schachman

Disqualifiers: Vertical root fractures, Non-restorable teeth, Class 3 mobility, Pregnant, Smoker, Systematic disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 7

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether using platelet-rich fibrin (PRF) during a type of dental surgery can reduce pain and improve healing. PRF, a substance made from blood, may help wounds heal faster. The trial compares outcomes from surgeries performed with and without PRF. It seeks participants who have had unsuccessful root canal treatments and specific issues with their front teeth or premolars. As a Phase 4 trial, this research aims to understand how an already FDA-approved and effective treatment can benefit more patients.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications.

What is the safety track record for Platelet Rich Fibrin?

Research has shown that Platelet Rich Fibrin (PRF) is generally safe for people. PRF aids in wound healing and reduces side effects after dental procedures. One study found that only 24% of people experienced pain with PRF, compared to 42% without it, suggesting that PRF might lessen post-surgery pain.

Another study found that PRF reduces pain soon after surgery, particularly in the first week. Made from the patient's own blood, PRF has fewer side effects and is easy to prepare. Overall, PRF appears well-tolerated and can aid in healing and pain relief in dental surgeries. ^{1 2 3 4 5}

Why are researchers enthusiastic about this study treatment?

Unlike standard treatments for tooth abscesses, which often involve antibiotics and drainage, Platelet Rich Fibrin (PRF) offers a novel approach by using the body's own healing agents. PRF is derived from a patient's blood and works by releasing growth factors that promote healing and tissue regeneration. Researchers are excited about PRF because it has the potential to enhance recovery after endodontic microsurgery by accelerating healing and reducing the risk of infection, offering a more natural and possibly more effective alternative to conventional treatments.

What evidence suggests that platelet rich fibrin might be an effective treatment for tooth abscess?

Research has shown that Platelet Rich Fibrin (PRF), which participants in this trial may receive, can accelerate wound healing and support tissue growth, particularly in dental surgeries like tooth extractions. Approximately two-thirds of studies have found that PRF significantly reduces post-surgery pain, especially in the initial days. PRF also enhances the healing of gums and other tissues around the tooth. While its effectiveness in root surgery remains under investigation, current evidence from similar dental surgeries appears promising. In this trial, some participants will undergo microsurgery with PRF, while others will have microsurgery without PRF. ^{2 6 7 8 9}

Who Is on the Research Team?

Mark Schachman, DMD

Principal Investigator

Are You a Good Fit for This Trial?

This trial is for individuals with conditions like tooth abscess, apical periodontitis, or general periodontitis. Specific eligibility criteria are not provided, so it's best to contact the study organizers for detailed requirements.

Inclusion Criteria

I have front teeth or premolars that had root canal treatment fail with a visible issue on an X-ray.

Exclusion Criteria

Pregnant

Smoker

My teeth cannot be fixed.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo endodontic microsurgery with or without Platelet-Rich Fibrin (PRF)

1 day

1 visit (in-person)

Follow-up

Participants are monitored for healing outcomes through follow-up exams, CBCT imaging, and pain response tracking

18 months

Multiple visits (in-person) at 6, 12, and 18 months

What Are the Treatments Tested in This Trial?

Interventions

• Platelet Rich Fibrin

Trial Overview The trial is testing the use of Platelet Rich Fibrin (PRF) in endodontic microsurgery to see if it reduces post-op pain, improves success rates and increases healing speed compared to standard treatment without PRF.

How Is the Trial Designed?

Group I: Microsurgery with Platelet Rich Fibrin Experimental Treatment 1 Intervention

Patents will have a blood draw completed so that PRF can be made. Endodontic microsurgery will then be completed. Prior to closing the flap, PRF will be placed in the osteotomy.

Group II: Microsurgery Alone Active Control 1 Intervention

Endodontic microsurgery will be completed without PRF. The osteotomy will remain empty as per standard procedure.

Who Is Running the Clinical Trial?

Mark Schachman

Lead Sponsor

Trials

1

Recruited

20+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8684569/

Efficacy of platelet-rich fibrin in promoting the healing of ... 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft ...

2. withpower.com withpower.com/trial/platelet-rich-fibrin-for-tooth-abscess-325a5

Platelet Rich Fibrin for Tooth Abscess (EMS Trial) Research shows that Platelet Rich Fibrin (PRF) helps in faster wound healing and tissue regeneration when used in oral surgeries, such as tooth extractions and ...

3. clinicaltrials.gov clinicaltrials.gov/study/NCT07192289

Using Platelet-rich Fibrin in Regenerative Endodontic ... The study will compare the effectiveness of PRF-based treatment with conventional blood clot-based regenerative endodontics. Official Title.

4. bmcoralhealth.biomedcentral.com bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-06238-1

The efficacy of platelet-rich fibrin (PRF) in post-extraction hard ... The analysis showed that PRF significantly improved soft tissue healing and reduced the incidence of AO. While PRF helped reduce pain, the ...

5. sciencedirect.com sciencedirect.com/science/article/pii/S1658361221000421

The effects of platelet-rich fibrin on post-surgical ... Based on the outcomes of our study, implanting PRF into surgical extraction sites can be helpful in reducing postoperative pain and improving soft tissue ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8348291/

The effects of platelet-rich fibrin on post-surgical complications ... Based on the outcomes of our study, implanting PRF into surgical extraction sites can be helpful in reducing postoperative pain and improving soft tissue ...

7. mdpi.com mdpi.com/2079-6412/12/2/247

The Assessment of the Usefulness of Platelet-Rich Fibrin in ... Pain occurred in 24% of the cases in Group I (with PRF), whereas in Group II, pain occurred in 42% of the cases. These results confirm that PRF ...

8. sciencedirect.com sciencedirect.com/science/article/pii/S2212555820300235

Investigation of the analgesic effect of platelet-rich fibrin on ... The present study proved the short-term efficacy of PRF immediately after surgery (within 1 week after surgery) for relieving pain.

9. journals.sagepub.com journals.sagepub.com/doi/10.1177/22808000241299588

Platelet-rich fibrin in dentistry - Ping Song, Dawei He, ... PRF is a second-generation platelet concentrate that is sourced from oneself, has fewer adverse effects, and is simple and safe to prepare.