This trial is testing whether non-deceptive placebos (open-label placebo, OLP) can help relieve symptoms of depression in adolescents. The investigators think that the mechanism by which OLP exerts its action in adolescent depression is by forming a positive expectation, which activates endogenous mu-opioid receptor (MOR)-mediated neurotransmission in a network of regions implicated in emotion, stress regulation, and the pathophysiology of MDD, namely, the anterior cingulate cortex (ACC) - striato - amygdalo - thalamic network.
2 Primary · 2 Secondary · Reporting Duration: At Baseline
60 Total Participants · 3 Treatment Groups
Primary Treatment: Open Label Placebo Group with Rationale · Has Placebo Group · N/A
Age < 65 · All Participants · 3 Total Inclusion CriteriaMark “Yes” if the following statements are true for you: