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What is Lo-Zumandimine
DrospirenoneThe Generic name of this drug
Treatment SummaryDrospirenone is a hormone used in combination with estrogen in birth control pills like Yaz and Estetrol. It can also be used to treat acne and PMDD. It has been linked to an increased risk of venous thromboembolism, but this has not been fully proven. The FDA states that the risk of thromboembolic events is lower than the risk during pregnancy or postpartum, so this should be taken into account when deciding whether to use this medication.
Yasminis the brand name
Lo-Zumandimine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Yasmin
Drospirenone
2001
64
Effectiveness
How Lo-Zumandimine Affects PatientsDrospirenone prevents pregnancy by stopping the growth of eggs in the ovaries and preventing ovulation. It also has anti-androgen effects, which can improve acne and hirsutism. Taking drospirenone combined with ethinyl estradiol has been found to have positive effects on cholesterol levels. Additionally, due to its similarity to natural progesterone, it may cause fewer side effects related to progesterone than other contraceptive drugs. However, taking drospirenone can increase the risk of developing venous thromboembolism or other cardiovascular events, especially in those who are smokers or are 35 and older
How Lo-Zumandimine works in the bodyDrospirenone and ethinyl estradiol work together to prevent pregnancy. They do this by stopping the release of hormones that trigger ovulation. They also change the consistency of cervical mucus, making it harder for sperm to reach an egg. Drospirenone is related to a diuretic drug, which makes your body get rid of extra salt and water. It also works against androgens, which can lead to acne and excessive hair growth. Finally, it reduces swelling in sebaceous follicles, which helps to prevent acne.
When to interrupt dosage
The amount of Lo-Zumandimine is contingent upon the determined illness, including moderate to serious indications, Menopause and Post-Menarche. The dosage also shifts as indicated by the technique of administration (e.g. Tablet, film coated - Oral or Oral) mentioned in the table beneath.Condition
Dosage
Administration
N-Cadherins
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophic
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Birth Control
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hormonal Contraception
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Atrophy of vulva
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
moderate to severe symptoms
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Acne Vulgaris
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Folate supplementation therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Post-Menarche
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Hot flashes
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Vasomotor System
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Adherence to Oral Contraceptive Therapy
, 0.25 mg, 0.5 mg, 3.0 mg, 1.0 mg, 4.0 mg
, Kit, Oral, Tablet, film coated, Tablet, film coated - Oral, Kit - Oral, Tablet - Oral, Tablet
Warnings
Lo-Zumandimine ContraindicationsCondition
Risk Level
Notes
Chronic Kidney Disease
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
Migraine, Classic
Do Not Combine
Porphyria
Do Not Combine
Breast
Do Not Combine
suspected pregnancy
Do Not Combine
Breast Milk Production
Do Not Combine
Metrorrhagia
Do Not Combine
Hypersensitivity
Do Not Combine
acute liver disease
Do Not Combine
Renal Insufficiency, Acute
Do Not Combine
Deep Vein Thrombosis (DVT)
Do Not Combine
Vision Loss
Do Not Combine
untreated endometrial hyperplasia
Do Not Combine
Tobacco Use
Do Not Combine
Liver Function Tests
Do Not Combine
Thrombophilia
Do Not Combine
Thromboembolism
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Adrenal Insufficiency
Do Not Combine
recent thromboembolic event
Do Not Combine
Breast
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Common Lo-Zumandimine Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Drospirenone may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Drospirenone.
Agmatine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Agmatine.
Aliskiren
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Aliskiren.
Anisodamine
Minor
The risk or severity of hyperkalemia can be increased when Drospirenone is combined with Anisodamine.
Lo-Zumandimine Toxicity & Overdose RiskThe most toxic dose of drospirenone for rats is greater than 2000mg/kg. Signs of drospirenone overdose may include nausea, irregular bleeding, and disturbances in the levels of sodium and potassium in the blood. In cases of overdose, the levels of these substances should be monitored closely, as well as for signs of metabolic acidosis and high potassium levels.
Lo-Zumandimine Novel Uses: Which Conditions Have a Clinical Trial Featuring Lo-Zumandimine?
At present, 104 active studies are being conducted to evaluate the utility of Lo-Zumandimine for Acne Vulgaris, Post-Menarche and N-Cadherins.Condition
Clinical Trials
Trial Phases
moderate to severe symptoms
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Atrophic
5 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
N-Cadherins
1 Actively Recruiting
Phase 1
Hormonal Contraception
0 Actively Recruiting
Atrophy of vulva
1 Actively Recruiting
Not Applicable
Post-Menarche
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Adherence to Oral Contraceptive Therapy
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Patient Q&A Section about lo-zumandimine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Lo-Zumandimine have estrogen?
"Lo-Zumandimine is a combined oral contraceptive (COC) that contains the synthetic forms of the female hormones estrogen and progesterone. It is indicated for use by women to prevent pregnancy, to treat symptoms of premenstrual dysphoric disorder (PMDD), and to treat moderate acne in women who are at least 14 years old and have started having their period."
Answered by AI
What kind of birth control is Zumandimine?
"This medication is a combination of an estrogen and a progestin. This product is used to prevent pregnancy."
Answered by AI
Is Lo-Zumandimine the same as Yaz?
"This medication is used to prevent pregnancy. It may also be used to treat premenstrual dysphoric disorder (PMDD) or acne in women who are using birth control pills.
This medication is used to prevent pregnancy. It may also be used to treat premenstrual dysphoric disorder (PMDD) or acne in women who are using birth control pills."
Answered by AI
Is Lo-Zumandimine good for acne?
"The drug Lo-Zumandimine is indicated for the treatment of moderate acne in women 14 years of age or older, who do not have any known conditions that would make taking oral contraception unsafe, and who have started having their period."
Answered by AI