Isibloom

Birth Control, Hormonal Contraception
Treatment
20 Active Studies for Isibloom

What is Isibloom

DesogestrelThe Generic name of this drug
Treatment SummaryDesogestrel is a medication derived from plant steroids that is used in combination with ethinyl estradiol to treat certain conditions. It is a type of third-generation progestogen and was first developed in 1972. It was approved by the FDA in 1992 and is now commonly used in Europe and the United States.
Desogenis the brand name
image of different drug pills on a surface
Isibloom Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Desogen
Desogestrel
1992
68

Effectiveness

How Isibloom Affects PatientsDesogestrel works by stopping ovulation in 97% of cycles. It also modifies the hormones luteinizing hormone and follicle stimulating hormone, causes menstrual delay, and thickens vaginal fluid. Desogestrel may also cause an increase in insulin, lipase activity, and fat deposits. Although desogestrel has been linked to an increased risk of blood clots, it usually does not cause a large change in total cholesterol levels.
How Isibloom works in the bodyDesogestrel is a drug that works by entering cells and binding to the progesterone receptor. This produces a transcriptional effect that changes the production of messenger RNA. Its active metabolite, etonogestrel, has high progestational activity and low androgenic activity.

When to interrupt dosage

The advised dosage of Isibloom is determined by the acknowledged affliction, such as Birth Control, Nursing Women and Hormonal Contraception. The measure of dosage is reliant on the method of delivery (e.g. Kit or Kit; Tablet - Oral) showcased in the below table.
Condition
Dosage
Administration
Birth Control
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet - Oral, Tablet, Kit - Oral
Hormonal Contraception
, 0.15 mg, 0.1 mg, 0.125 mg, 0.375 mg
, Kit, Oral, Tablet - Oral, Tablet, Kit - Oral

Warnings

Isibloom has twenty-five contraindications, so it should not be ingested if you have any of the circumstances specified in the following table.Isibloom Contraindications
Condition
Risk Level
Notes
Stroke
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver Cancer
Do Not Combine
Endometrial Neoplasms
Do Not Combine
Thromboembolism
Do Not Combine
Thromboembolism
Do Not Combine
Major Surgery
Do Not Combine
benign hepatic adenoma
Do Not Combine
Breast Cancer
Do Not Combine
Liver Diseases
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast
Do Not Combine
Type 2 Diabetes
Do Not Combine
Coronary Disease
Do Not Combine
Thrombophlebitis
Do Not Combine
Thrombophilia
Do Not Combine
Diastolic blood pressure
Do Not Combine
Hypertension
Do Not Combine
Jaundice, Obstructive
Do Not Combine
Venous Thrombosis
Do Not Combine
Icterus
Do Not Combine
focal neurological symptoms
Do Not Combine
Heart Valve Diseases
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
There are 20 known major drug interactions with Isibloom.
Common Isibloom Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Desogestrel.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Desogestrel.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Desogestrel.
Enasidenib
Major
The metabolism of Enasidenib can be increased when combined with Desogestrel.
Etoposide
Major
The metabolism of Etoposide can be increased when combined with Desogestrel.
Isibloom Toxicity & Overdose RiskTaking large doses of desogestrel can cause strong hormonal reactions, but it is generally not toxic. Tests in rats showed that the toxic dosage of desogestrel is higher than 2000mg/kg. Overdosing on desogestrel may cause nausea and missed periods, but no serious effects have been reported. Desogestrel does not appear to increase the risk of breast cancer, but there is some evidence that it may increase the risk of cervical pre-cancerous changes. However, these results are not conclusive.
image of a doctor in a lab doing drug, clinical research

Isibloom Novel Uses: Which Conditions Have a Clinical Trial Featuring Isibloom?

38 active trials are being conducted to investigate the potential of Isibloom to affect Nursing Women, Fertility Control and Hormonal Contraceptive measures.
Condition
Clinical Trials
Trial Phases
Birth Control
22 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2
Hormonal Contraception
0 Actively Recruiting

Isibloom Reviews: What are patients saying about Isibloom?

5Patient Review
5/11/2022
Isibloom for Birth Control
I've been taking this pill for over five years and it works if you take it correctly. The only downside is that it makes my boobs feel heavy, which can be a bit uncomfortable. Otherwise, I haven't had any issues with mood or anything else.
4.7Patient Review
11/15/2019
Isibloom for Birth Control
I'm pretty darn pleased with this birth control. I can skip periods, which is great, and it's helped my acne. The only complaint I have is that I get mild headaches when I do get my period, but otherwise I'm thrilled!
3Patient Review
10/1/2018
Isibloom for Premenstrual Disorder with a State of Unhappiness
I had some bad side effects from this pill, and I'll never take it again. Nausea, breast pain, lower back pain, pelvic pain, and a mild facial rash were all problems I experienced.
1.3Patient Review
10/6/2021
Isibloom for Premenstrual Disorder with a State of Unhappiness
Made me feel really bad.

Patient Q&A Section about isibloom

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of birth control is Isibloom?

"Desogestrel is a progestin and ethinyl estradiol is an estrogen.

Isibloom is an oral contraceptive that contains the progestin desogestrel and the estrogen ethinyl estradiol. It is indicated for the prevention of pregnancy in women who elect to use oral contraceptives as a method of contraception. Isibloom is available in generic form."

Answered by AI

Can Isibloom cause infertility?

"The Isibloom birth control pill contains female hormones that prevent ovulation (the release of an egg from an ovary). Isibloom also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus."

Answered by AI

Is Isibloom a generic birth control?

"The active ingredients in Isibloom are ethinyl estradiol and desogestrel, which are naturally occurring hormones that prevent ovulation and also alter the cervical and uterine linings to prevent sperm movement and fertilized egg attachment."

Answered by AI

Will Isibloom make me gain weight?

"If you're concerned about weight gain while taking a birth control pill like Isibloom, be sure to maintain an active lifestyle and healthy diet. Some women experience a slight increase in weight when they start taking the pill, but this is usually because of fluid retention, not an increase in body fat."

Answered by AI

Clinical Trials for Isibloom

Image of University of California, San Diego in La Jolla, United States.

Lidocaine for Pain Control in Birth Control

18 - 50
Female
La Jolla, CA
The goal of this research study is to learn more about how different uses of a numbing medication might affect pain levels while getting an IUD placed. The investigators are also studying participants opinions of their clinicians' empathy. The investigators are inviting patients who arrive at their clinic visit seeking an IUD. Usually, at University of California, San Diego (UCSD), for patients who have never delivered a baby, clinicians use a buffered paracervical block for before IUD placement. The purpose of this research study is to investigate whether a "buffered" (2 cc of sodium bicarbonate, 18 cc of 1% lidocaine) paracervical block (numbing medication given on both sides of the cervix) is effective in reducing pain during IUD placement in individuals with prior C-sections, the difference between buffered and unbuffered for nulliparous patients, and whether a medicated gel reduces pain with the paracervical block.
Recruiting
Paid Trial
University of California, San DiegoSheila K Mody, MD, MPH
Image of EmpoweRx, Inc in Del Mar, United States.

HAPPI Software for Birth Control Access

18+
All Sexes
Del Mar, CA
The goal of this clinical trial is to learn if use of the HAPPI software can improve pharmacist-provided birth control services. The main questions it aims to answer are: 1. Does the HAPPI software make it easier for pharmacists to provide birth control services in their pharmacy? 2. Does the HAPPI software make it easier for patients to access birth control? Researchers will compare pharmacists' implementation and patients' access when using the HAPPI software and when not using the HAPPI software to see if the software improves implementation and access. Participants will include pharmacists and patients. Pharmacists will be asked to provide birth control services as normal while using the HAPPI software. Patients will be asked to receive birth control services from a pharmacist as normal, while using the HAPPI software.
Recruiting
Has No Placebo
EmpoweRx, Inc
Image of Calabasas Pharmacy in Calabasas, United States.

Electronic Health Record Platform for Birth Control

18 - 51
Female
Calabasas, CA
Hormonal contraceptives are medications that require a prescription, traditionally from a physician or advanced practice provider. Over the past decade, pharmacists have gained the authority to prescribe contraceptives in many states, allowing patients to access these medications directly in pharmacies without first seeing another healthcare provider. The Pharmacist Resource to Implement Services as Modules (PRISM) is an Electronic Health Record platform designed to streamline workflows and provide clinical decision support, making it easier and safer to deliver clinical services in community pharmacies. This pilot study will evaluate patient-reported outcomes for women receiving contraceptive services from pharmacists using the PRISM platform at five community pharmacies across the United States over a 12-week period. The study will assess the quality of care, contraception continuation and failure rates, side effect rates, preventative healthcare utilization, and overall patient experience with pharmacy contraceptive services.
Waitlist Available
Has No Placebo
Calabasas Pharmacy (+4 Sites)OvaryIt, LLC
Have you considered Isibloom clinical trials? We made a collection of clinical trials featuring Isibloom, we think they might fit your search criteria.Go to Trials
Image of Jackson State University/Department of Behavioral & Environmental Health in Jackson, United States.

PEN-3 Intervention for Postpartum Depression

18 - 45
Female
Jackson, MS
Maternal mortality in the United States is higher than in peer nations and has not decreased since 1990. Beyond mortality, severe maternal mortality impacts far too many women. Not only are these high rates alarming, but notable racial/ethnic and socioeconomic disparities exist. These inequities are highly regional, with women living in the rural southeast part of the United States, including the Mississippi Delta, having the highest rates of maternal mortality and morbidity. Unfortunately, these disparities have proven to be stubbornly resistant to interventions, necessitating an innovative multifaceted approach focused on community practice, building trust, and prioritizing patient voices. To meet this need, this proposal aims to establish the Mississippi Delta Research Center of Excellence for Maternal Health with the goal of addressing preventable maternal mortality, decreasing severe maternal morbidity, and promoting maternal health equity in partnership with the Mississippi Delta community. This patient-clinical linkages intervention study will evaluate the effectiveness of a multilevel and multisector communication and health literacy strategy to increase trust and engagement in postpartum healthcare among women in the Mississippi Delta, with a specific focus on Black women, their families, and their communities. These research projects both have the overarching goal of partnering with the community to determine and meet the needs of pregnant and postpartum women in the Mississippi Delta and address the disparities within maternity health and health care outcomes.
Recruiting
Has No Placebo
Jackson State University/Department of Behavioral & Environmental HealthMary Shaw, PhD
Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Birth Control Pills and DNA Interaction

18 - 45
Female
Aurora, CO
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these birth control pills work to prevent pregnancy. The investigators are also interested in exploring how these differences in our DNA can also explain why patients taking the exact same formulation of birth control pill will experience very different side effects. The main questions it aims to answer are: * Do individuals with the CYP3A7\*1C variant have increased metabolism of both desogestrel and ethinyl estradiol when taking a combined oral contraceptive pill? * Do individuals with the CYP3A7\*1C variant experience higher rates of breakthrough ovulation while taking a desogestrel/ethinyl estradiol combined oral contraceptive pill? * What novel genetic loci are associated with alterations in steroid hormone pharmacokinetics and pharmacodynamics among a larger cohort of combined oral contraceptive pill users? Participants will take a specific formulation of combined oral contraceptive pill (desogestrel/ethinyl estradiol) and undergo the following procedures: * Blood draw to measure the amount of progestin and estrogen in their system from the combined oral contraceptive pill * Questionnaires to assess side effects possibly caused by the combined oral contraceptive pill * Blood draw to measure endogenous hormone levels and biomarkers that may be affected by the combined oral contraceptive pill * A transvaginal ultrasound to measure any ovarian follicles (optional procedure)
Phase 4
Recruiting
University of Colorado Anschutz Medical Campus (+2 Sites)Aaron M Lazorwitz, MD, PhD
Have you considered Isibloom clinical trials? We made a collection of clinical trials featuring Isibloom, we think they might fit your search criteria.Go to Trials
Image of Greater Boston Health Center in Boston, United States.

SBIRT for Alcohol and Substance Use Disorders

18+
All Sexes
Boston, MA
The goal of this clinical trial is to test the effectiveness of evidence-based Screening, Brief Intervention, and Referral to Treatment (SBIRT) among adult patients who screen positive to one or more risky alcohol or substance use behaviors while seeking care at a sexual and reproductive health (SRH) clinic. The main questions it aims to answer are: * Does SBIRT impact patients' alcohol and substance use, SRH, mental health, physical health, quality of life, and wellbeing? * Does SBIRT effectiveness differ by ethnicity, socioeconomic status, age, gender, and urbanicity? * Does SBIRT effectiveness differ by delivery mode (in-person vs. telemedicine)? Participants will receive in-person and telemedicine SBIRT, or usual care. Participants will complete surveys at interviews at baseline, 30 days, and 3 months. Researchers will compare patients who received SBIRT to patients who receive usual care to see if patients who receive the SBIRT intervention have a greater reduction in negative outcomes as compared to those who receive usual care. In this setting, usual care consists of basic quantity and frequency questions asked inconsistently as part of the admission process and varying by provider, with no standardized approach to screening, treatment, follow-up, or referral.
Recruiting
Has No Placebo
Greater Boston Health Center (+3 Sites)Kelli S Hall, MD
Image of OHSU in Portland, United States.

Progestin Contraceptives for Birth Control Effects

18 - 40
Female
Portland, OR
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first year of progestin contraception use. Participants will choose to receive the contraceptive implant (Etonogestrel implant also called Nexplanon) or the contraceptive injectable (Depo-medroxyprogesterone acetate (DMPA) also called Depo-Provera) for up to 12 months. They will be asked to have 4 endometrial biopsies over the course of the study, as well as blood draws, physical exams, and pregnancy tests. Participants will also use a daily text message or email diary to report bleeding patterns. This study's plan is to comprehensively phenotype bleeding patterns and profile the entire endometrium using single-cell RNA seq data (sCRNAseq).
Phase < 1
Recruiting
OHSUAlison Edelman, MD
Have you considered Isibloom clinical trials? We made a collection of clinical trials featuring Isibloom, we think they might fit your search criteria.Go to Trials
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