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What is Orilissa
ElagolixThe Generic name of this drug
Treatment SummaryElagolix (brand name Orilissa) is a medication used to treat moderate to severe pain caused by endometriosis. It is the first and only oral medication specifically developed for women with endometriosis pain. Endometriosis is a common gynecologic disorder that can cause women to suffer from debilitating pain for up to ten years before receiving a proper diagnosis. Orilissa was approved by the FDA under priority review, allowing healthcare professionals to provide women with another option for treating their endometriosis symptoms.
Orilissais the brand name
Orilissa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Orilissa
Elagolix
2018
3
Effectiveness
How Orilissa Affects PatientsIn a study with healthy women, the elagolix 150 mg once daily regimen and the 200 mg twice daily regimen resulted in a 50% and 32% ovulation rate, respectively. In trials with women with endometriosis, it was seen that these doses caused a reduction in estradiol concentrations to around 42 pg/mL and 12 pg/mL respectively. Additionally, a single dose of 1200 mg was investigated in a study with 48 premenopausal women, and it was found that this dose did not cause any prolonged effects on the QTc interval.
How Orilissa works in the bodyEndometriosis is a condition where tissue similar to what lines the uterus grows outside of it, leading to pain and other symptoms. Elagolix is a medicine taken orally that stops this tissue from growing. It does this by blocking a hormone that tells the tissue to grow, which then lowers the body's levels of estrogen and progesterone.
When to interrupt dosage
The recommended measure of Orilissa is contingent upon the diagnosed affliction, including Menorrhagia, Endometriosis and Endometriosis. The dosage fluctuates as per the technique of delivery (e.g. Tablet, film coated or Tablet) detailed in the table beneath.Condition
Dosage
Administration
Endometriosis
, 150.0 mg, 200.0 mg, 600.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pain
, 150.0 mg, 200.0 mg, 600.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Menorrhagia
, 150.0 mg, 200.0 mg, 600.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Uterine Fibroids
, 150.0 mg, 200.0 mg, 600.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Orilissa ContraindicationsCondition
Risk Level
Notes
Osteoporosis
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Elagolix may interact with Pulse Frequency
Common Orilissa Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Elagolix.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Elagolix.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Elagolix.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Elagolix.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Elagolix.
Orilissa Toxicity & Overdose RiskSigns of an overdose on elagolix may include hot flashes, headaches, nausea, sleeplessness, changes in mood, missed or irregular periods, depression, anxiety, joint pains, bone loss, and elevated liver enzymes. Elagolix is typically taken for up to two years at the 150mg dose or up to six months at the 200mg dose, and can cause a decrease in bone mineral density with increasing duration of use. For women with moderate liver problems, the recommended dose is 150mg once daily for up to six months.
Orilissa Novel Uses: Which Conditions Have a Clinical Trial Featuring Orilissa?
15 active trials are currently investigating the potential of Orilissa in alleviating Menorrhagia, Endometriosis and Endometrial Disease.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Menorrhagia
3 Actively Recruiting
Phase 3, Phase 4, Not Applicable
Endometriosis
30 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 2, Phase 4, Phase 1
Uterine Fibroids
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4
Orilissa Reviews: What are patients saying about Orilissa?
5Patient Review
3/28/2022 Endometriosis has been a issue for me for 15 years, and I've had to have six different surgeries because of it. Thankfully, this medication has finally provided some relief.
5Patient Review
8/27/2022 I had pelvic pain, bloating, and fatigue for 15 years. This medication started working after the first month of taking it. No more periods is amazing! Worst side effect was hot flashes. A true miracle medication that has given me my life back!
4.7Patient Review
11/8/2021 I have been on this medication for over a year now and I am really surprised by all the negative reviews I am reading. I have not experienced any headaches, nausea, or hot flashes. This medicine has worked great for me and my period pain is gone! With my insurance, I only pay five dollars for a month supply.
2Patient Review
11/4/2021 I experienced significant memory loss and depression while on this medication. Additionally, it did not help with my pain or menstrual cycles as intended. I'm writing this review in hopes of helping others avoid the same issues I went through.
1.7Patient Review
10/12/2021 I was prescribed this medication from my Gyn because of my severe painful menstruation. I started in July 2021. Instantly felt the side effects - joint pains, feet and hands were always numb, hot flashes.. When I decided to stop taking orilissa, my endometriosis got worse..Dealing with excruciation pain everyday on the right side of my abdomen and radiates to my rectum. I have to take pain meds to go on with my day otherwise I can't function. Life is no longer normal. very sad!
Patient Q&A Section about orilissa
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Do you gain weight on Orilissa?
"If you gain weight while taking Orilissa, it's not something to worry about, as it's not a common side effect. However, if you're concerned about your weight, talk to your doctor, who can recommend ways to maintain a healthy weight."
Answered by AI
What is Orilissa used for?
"ORILISSA is a medicine used to treat moderate to severe pain associated with endometriosis in adults. It is not known if it is safe and effective in children."
Answered by AI
What type of drug is Orilissa?
"Orilissa is a drug that works by reducing levels of certain hormones, such as estrogen, in the body. Mirena is a drug that contains a progestin hormone. These drugs work differently to reduce levels of certain hormones in the body."
Answered by AI
What does Orilissa do to your body?
"Orilissa prevents GnRH from having any effect. GnRH is a hormone that is produced by the brain. When GnRH is released, it starts a chain of events that tell the body to produce hormones like estrogen and progesterone. These are the two main sex hormones responsible for the menstrual cycle."
Answered by AI