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What is Nesina
AlogliptinThe Generic name of this drug
Treatment SummaryAlogliptin is an oral medication that helps control blood sugar levels by inhibiting the activity of the enzyme dipeptidyl peptidase-4 (DPP-4). It is available as a benzoate salt and is mainly composed of the R-enantiomer. Alogliptin was approved by the FDA in 2013 and does not convert to the S-enantiomer when taken.
Nesinais the brand name
Nesina Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nesina
Alogliptin
2013
26
Approved as Treatment by the FDA
Alogliptin, also known as Nesina, is approved by the FDA for 3 uses which include Type 2 Diabetes and Diet .Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone
Diet
Used to treat Diet in combination with Pioglitazone
Physical Activity
Used to treat Exercise in combination with Pioglitazone
Effectiveness
How Nesina Affects PatientsAlogliptin starts to reduce the levels of an enzyme (DPP-4) within 2-3 hours after being taken, and it continues to keep levels low for up to 24 hours with doses of 25 mg or higher. It also helps to lower glucagon and increase levels of a hormone (GLP-1) that helps regulate blood sugar levels. Taking alogliptin will not affect the time it takes for your heart to beat.
How Nesina works in the bodyAlogliptin helps control blood sugar levels by blocking an enzyme called dipeptidyl peptidase 4 (DPP-4). This enzyme usually breaks down the hormones GIP and GLP-1, which stimulate insulin production. Alogliptin prevents this breakdown, so more of these hormones are in the blood. This increases insulin production, suppresses glucagon production, and helps with feelings of fullness.
When to interrupt dosage
The amount of Nesina is contingent upon the established affliction, including Diet, Physical Activity and Type 2 Diabetes. The dosage is subject to the mode of delivery (as outlined in the table below).Condition
Dosage
Administration
Diet
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Type 2 Diabetes
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Physical Activity
, 6.25 mg, 12.5 mg, 25.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Nesina.Common Nesina Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Alogliptin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Alogliptin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Alogliptin.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Alogliptin.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Alogliptin.
Nesina Toxicity & Overdose RiskAlogliptin overdose may lead to common side effects such as a sore throat, headache, and respiratory infection. These symptoms occur in at least 4% of those who take alogliptin and more often than in those taking a placebo.
Nesina Novel Uses: Which Conditions Have a Clinical Trial Featuring Nesina?
196 active studies are in progress to assess the potential of Nesina for improving Physical Activity, managing Type 2 Diabetes and providing Dietary benefits.Condition
Clinical Trials
Trial Phases
Diet
5 Actively Recruiting
Not Applicable
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Nesina Reviews: What are patients saying about Nesina?
5Patient Review
11/11/2013 This medication has been extremely effective for me. I take it along with a low dose of Amaryl each day, and my A1C level has dropped from 7.3 to 5.9 in just three months!
1Patient Review
9/13/2016 After taking Januvia for many years, my insurance company made me switch to Nesina. My blood sugar has been spiking since I started taking it, and I've already switched back to Januvia at my own expense.
Patient Q&A Section about nesina
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the medication Nesina used for?
"An injectable medication, Alogliptin is used to help manage blood sugar levels in people with type 2 diabetes. When combined with a proper diet and exercise regimen, this medication can help to prevent the onset of serious complications from diabetes, such as kidney damage, blindness, nerve problems, loss of limbs, and sexual dysfunction."
Answered by AI
Does Nesina have metformin in it?
"The drugs in Nesina Met are alogliptin and metformin hydrochloride. Alogliptin is given in a dose of 12.5 mg per 1000 mg metformin hydrochloride."
Answered by AI
What is the difference between Januvia and Nesina?
"If you're struggling to get your blood sugar under control, Januvia (sitagliptin) could be a good addition to your treatment plan. Januvia lowers blood sugar levels and is taken orally, so you don't have to worry about injections. Nesina (alogliptin) is another option for oral treatment, but it's not as effective as Januvia."
Answered by AI
Does Nesina cause weight gain?
"Nesina will not make you gain weight. It helps the body to produce more insulin when blood sugar is high, and also tells the liver to reduce sugar production."
Answered by AI