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What is Seasonale
EthinylestradiolThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the hormone estrogen. It was created in 1938 with the goal of making it easier for the body to absorb estrogen when taken orally. Today, ethinylestradiol is most commonly used in birth control pills to prevent pregnancy. The FDA approved the use of ethinylestradiol in 1943.
LOESTRIN Fe 1.5/30is the brand name
Seasonale Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679
Approved as Treatment by the FDA
Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .Birth Control
Used to treat Contraception in combination with Levonorgestrel
Effectiveness
How Seasonale Affects PatientsEthinylestradiol is a synthetic form of estrogen that works to prevent ovulation. It is taken once a day and is relatively safe, though it has been linked to increased risk of clotting issues. Patients should be aware of this potential risk when taking the drug.
How Seasonale works in the bodyEthinylestradiol is a synthetic estrogen used in combined oral contraceptives. It helps to prevent pregnancy by suppressing ovulation and thickening cervical mucus. It also has effects on the endometrium, which stops a fertilized egg from implanting. Ethinylestradiol reduces luteinizing hormone, decreasing blood flow to the endometrium, and increases sex hormone binding globulin.
When to interrupt dosage
The recommended portion of Seasonale is contingent upon the diagnosed condition, such as Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The amount of dosage is subject to the method of delivery specified in the table below.Condition
Dosage
Administration
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopausal Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Mild to Moderate Acne
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Warnings
Seasonale ContraindicationsCondition
Risk Level
Notes
Heavy Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
Breast
Do Not Combine
Impaired Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
Common Seasonale Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Seasonale Toxicity & Overdose RiskWomen who overdose on birth control pills may experience signs such as bleeding between periods, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment for overdose includes monitoring for potassium levels, sodium levels, and signs of acidosis in the bloodstream.
Seasonale Novel Uses: Which Conditions Have a Clinical Trial Featuring Seasonale?
38 active trials are being conducted to investigate the potential of Seasonale as a Folate supplementation therapy, Premenstrual Dysphoric Disorder and Menopause treatment.Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Patient desires oral contraception for birth control
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Menopause
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Seasonale Reviews: What are patients saying about Seasonale?
5Patient Review
1/13/2016 I've been on this medication for over two years and I almost forget what it's like to have a period! The first nine months there was some breakthrough bleeding, but it all sorted itself out. Different people will have different experiences, but mine has been much better than before choosing this birth control method.
5Patient Review
1/13/2016 I've been on this medication for over two years and have almost forgotten what it's like to have a period. The first nine months there was some breakthrough bleeding, but it all sorted itself out eventually. Different people will have different experiences, but mine has been much better than what I was experiencing before choosing this birth control method.
4.7Patient Review
8/2/2015 I'm still trying this medication, but I think it's going well so far. I have had some breakthrough bleeding, but nothing that's been unmanageable. One person's side effects shouldn't necessarily dissuade you from taking the medication--everyone reacts differently. I've suffered from migraines since I was 10 years old and this hasn't made them any worse or more frequent. Additionally, I haven't experienced any weight gain or mood swings. Ultimately, it depends on the individual whether or not this medication will be effective. So far, it has been for me and I'm glad my doctor recommended it.
4.7Patient Review
8/2/2015 I've been pretty happy with this treatment so far. I have had some breakthrough bleeding, but it's manageable and not really a big deal. I know that everyone reacts to medications differently, so just because someone has bad side effects doesn't mean that everyone will. For me personally, I haven't had any weight gain or mood swings. If you're considering this medication, I say give it a shot – it might work wonders for you like it did for me.
4.3Patient Review
2/16/2021 I've only been taking this for two months as a trial for my endometriosis. I haven't had any issues so far and am due for my cycle next month, so we'll see how it goes then.
4.3Patient Review
2/16/2021 So far, so good. My doctor prescribed this to me for my endometriosis and I haven't had any negative side effects or problems yet. Next month will be a better test since that's when I'm due for my cycle.
3.7Patient Review
3/4/2019 I've been on this medication for nearly a decade and it has led to me developing a severe hepatic adenoma. I now require surgery and time off from work, which is extremely difficult. After doing some research, I found that other women have experienced similar conditions but there has been no change to the label or warning us of these potential risks.
3.7Patient Review
3/4/2019 After long-term use of this medication, I now have to get surgery for a severe hepatic adenoma. This will require me to be away from work for an extended period of time. A quick Google search showed me that other women have experienced similar conditions after taking this drug; however, the manufacturer has not changed the label to inform consumers of this potential side effect.
3.3Patient Review
8/3/2016 I've used this brand for the past three years. I still experience random spotting, which can last up to a week; my depression increased; I gained slight weight; and my chest grew from a 34C to 34DDD.
3.3Patient Review
8/3/2016 I've been using this brand for the past three years. I still have random spotting, which can last up to a week, my depression increased, gained slight weight, and my chest grew from a 34C to 34DDD.
2.7Patient Review
2/22/2016 I was really disappointed with this treatment. I started taking it for endometriosis but ended up with an intense migraine that lasted the entire two weeks I took it.
2.7Patient Review
2/22/2016 I started taking this medication for endometriosis, but I quickly developed an intense migraine that lasted the entire two weeks I was on the medication. I had to stop taking it because it was too unbearable.
2Patient Review
6/7/2021 I bled for six months while my doctor said to give it time. I'm finally done with the bleeding, cramps, low sex drive, and dryness.
2Patient Review
6/7/2021 I bled for six months while my doctor said to give it time. I'm finally done with the bleeding, cramps, low sex drive, and dryness.
1Patient Review
7/25/2022 I bled for thirteen days straight and saw no end in sight. The first month I gained ten pounds, and the second month my period wouldn't stop.
1Patient Review
7/25/2022 I bled for thirteen days straight with no end in sight. The first month I gained ten pounds, and the second month my period just wouldn't stop.
Patient Q&A Section about seasonale
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Do you get a period on Seasonale?
"If you are experiencing vaginal bleeding or spotting between periods, especially during the first few months of using this medication, speak to your doctor or pharmacist. You should not have a period during the 3 months that you are taking the active medication."
Answered by AI
What is the difference between Seasonique and Seasonale?
"Seasonale is a birth control pill that women take inactive pills during their four yearly periods. Seasonique is a similar pill but with a low dose of estrogen which may help with breakthrough bleeding, according to Barr Pharmaceuticals spokeswoman Carol Cox."
Answered by AI
Does Seasonale cause weight gain?
"Some women worry about weight gain when taking birth control pills such as Seasonale. While the pill might result in an increased appetite, the weight gain is mostly due to water retention and not actual fat."
Answered by AI
What are Seasonale hormones?
"Seasonale is an extended-cycle combination oral contraceptive that consists of 84 active pink tablets, each containing 0.15 mg of levonorgestrel, a synthetic progestin, and 0.03 mg of ethinyl estradiol, an estrogen. There are also 7 white inert tablets without hormones."
Answered by AI