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What is Setlakin
EthinylestradiolThe Generic name of this drug
Treatment SummaryLevonorgestrel is a type of synthetic hormone used in contraception and hormone therapy. It is known by the brand name Plan B and is used as a single agent in emergency contraception or released from an intrauterine device. Levonorgestrel is also available as a long-term subdermal implant and is used in combination contraceptives. FDA approved in 1982, levonorgestrel is the most commonly used emergency contraceptive worldwide as it is highly effective and has few estrogenic side effects.
LOESTRIN Fe 1.5/30is the brand name
Setlakin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679
Approved as Treatment by the FDA
Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .Birth Control
Used to treat Contraception in combination with Levonorgestrel
Effectiveness
How Setlakin Affects PatientsLevonorgestrel can be used as an emergency contraceptive to prevent pregnancy up to 72 hours after intercourse. It works by stopping ovulation, fertilization, and implantation. It is 89% effective when taken correctly. Levonorgestrel can also be used in intrauterine and implantable devices, which are more than 99% effective in preventing pregnancy. Finally, it is sometimes used as part of hormone therapy to lower the risk of endometrial carcinoma caused by estrogen.
How Setlakin works in the bodyLevonorgestrel works to prevent pregnancy in several ways. It suppresses the release of hormones that trigger ovulation, preventing an egg from being released from the ovary. It also thickens cervical mucus, making it harder for sperm to enter the uterus and fertilize the egg. Finally, it causes changes in the endometrium which can make it harder for a fertilized egg to implant. In addition to its contraceptive effects, levonorgestrel can be used in combination with other hormones to reduce the risk of endometrial cancer in women taking estrogen therapy.
When to interrupt dosage
The measure of Setlakin depends upon the diagnosed state, including Endometrial Hyperplasia, Emergency Contraception and Hypermenorrhea. The amount of dosage is contingent upon the approach of administration noted in the table underneath.Condition
Dosage
Administration
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Mild to Moderate Acne
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopausal Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Warnings
Setlakin has forty-three contraindications and should not be employed when encountering any of the conditions detailed in the following table.Setlakin ContraindicationsCondition
Risk Level
Notes
Heavy Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
Breast
Do Not Combine
Impaired Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
Common Setlakin Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Setlakin Toxicity & Overdose RiskThe lowest dose of levonorgestrel that is toxic to rats is greater than 5000mg/kg. Symptoms of an overdose may include nausea and bleeding, and there is no specific antidote. If someone has overdosed on levonorgestrel, they should receive supportive care and contact their local poison control center.
Setlakin Novel Uses: Which Conditions Have a Clinical Trial Featuring Setlakin?
99 active studies are currently analyzing the potential of Setlakin in treating Postmenopausal Osteoporosis, Women Who Have Had at Least One Child and Endometrial Hyperplasia.Condition
Clinical Trials
Trial Phases
Birth Control
31 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Patient desires oral contraception for birth control
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Menopause
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Setlakin Reviews: What are patients saying about Setlakin?
3.3Patient Review
1/10/2018 I've been experiencing unusual and heavy bleeding for the past five months. I'm not sure if this is due to the birth control or not, but it's otherwise a great medication with no weight gain or skin problems.
2.7Patient Review
4/23/2017 The neuromuscular pain I've been experiencing in my back, hips and shoulders is really bad. It's only been a week and I'm already considering switching to a different generic brand. The over the counter NSAIDS I'm taking for relief aren't doing enough. At this point, I might even prefer having painful periods again.
2.3Patient Review
8/6/2016 I was on Jolessa for years, but my pharmacy switched me to Setlakin. I've been bleeding for over 70 days now since my last period. I had an ultrasound--no fibroids or cysts. Think it might be the Setlakin
Patient Q&A Section about setlakin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should I start taking Setlakin?
"For each 91-day course, take the first pink tablet on the first Sunday after the onset of menstruation. If menstruation begins on a Sunday, take the tablet on that day."
Answered by AI
What are the side effects of Setlakin?
"You may experience some side effects while taking this medication, such as nausea, vomiting, headaches, bloating, breast tenderness, swelling of the ankles or feet (fluid retention), or weight change. Some women also experience vaginal bleeding between periods (spotting), especially during the first few months of use."
Answered by AI
What kind of pill is Setlakin?
"SetlakinTM is an extended-cycle combination oral contraceptive that consists of 84 pink active tablets. Each tablet contains 0.15 mg of levonorgestrel, a synthetic progestin, and 0.03 mg of ethinyl estradiol, an estrogen. There are also 7 white inert tablets (without hormones) in the combination."
Answered by AI
What is Setlakin generic for?
"Introvale and Setlakin are both generic and brand versions of the same birth control pill. They contain the same active ingredients in the same doses, so they will work the same way when taken as directed."
Answered by AI