IVA337 for Fatty Liver

"In this small observational study, no effect of an experimental agent was seen for either of the two endpoints of cirrhosis and non-cirrhotic liver. Although this study was not powered to exclude clinically significant benefits and thus is only intended as a preliminary study, this lends weight to the belief that the liver does not remodel. A larger, longer-term trial is necessary to examine these issues further." - Anonymous Online Contributor

"Fibrosis, a non-specific term for fibrotic tissue, describes an abnormal tissue response of the body to injury, such as inflammation or infection. The term fibrosis can refer to many different diseases and conditions such as lung fibrosis, liver fibrosis, and heart fibrosis, which causes abnormal cell growth, cell function, or the formation of scarring, in response to long-term or repeated overuse.\n" - Anonymous Online Contributor

"Fibrosis may develop in several joints, but the main cause is unknown. There is evidence that fibrosis may be associated in some ways with genetics, smoking and with the use or clearance (or lack of) drugs, and with physical trauma or injury. Fibroses may also develop as a result of aging and the depletion of other tissues and organs." - Anonymous Online Contributor

"Fibrosis is an age-dependent disease. The majority of cases present as part of either interstitial lung disease or pulmonary hypertension. Fibrogenic conditions account for approximately 10% of cases of lung transplantation. The main treatments include corticosteroids plus azathioprine plus other immunosuppressive therapies. Bronchitis (a common feature of some patients with fibrosis) is treated with azithromycin. There is some doubt regarding whether there are definitive treatments for fibrosis. This is particularly so in patients who present with chronic symptoms. [Find some common treatments for fibrosis through Power." - Anonymous Online Contributor

"Fibrosis involves different tissues in the body, such as tissues in the skin. The most commonly involved lesions involve the lungs, liver, pancreas, and kidneys.\n\nThe initial observation in a number of cases have identified an association of fibrotic changes with the presence of systemic disease. In one case, a patient with no history of systemic disease was found to have fibrosis involving the lungs. Furthermore, in another case of suspected coexisting systemic disease, a review of a biopsy of the liver demonstrated the presence of fibrosis.\n\nThere is still much debate in the field with respect to the underlying cause of fibrosis. Although no clear associations have been established, multiple theories exist." - Anonymous Online Contributor

"The prevalence of fibrosis is increasing in the US, with rates varying widely among racial groups. As we move forward to reduce the burden of chronic kidney disease associated with hypertension in the US through the National Action Program on Chronic Kidney Disease, it is critical that the number of people with fibrosis be accurately characterized in order to achieve maximal outcomes." - Anonymous Online Contributor

"It would seem that at this time there are no treatments available that would improve the condition of the patients that have fibrosis. With regard to the new compounds that are being developed that are being studied, it may take many years before the drugs have been approved by the FDA. Although there are some new innovations in medical treatment, this has not come to fruition yet and for the present and for the foreseeable future, it would seem that patients with fibrosis should still be evaluated by a specialist to see if they would be suitable candidates for any of these new compounds." - Anonymous Online Contributor

"There is a tremendous variability of fibroid size and degree, but there is no reliable correlation between the size and degree of fibrous tissue within the fibromatosis, the extent of the underlying disease, and the clinical severity of symptoms." - Anonymous Online Contributor

"Treatment is mainly used to control pain. There is no treatment for the underlying condition, but there is a large number of trials investigating treatments for other fibrotic conditions. There is limited literature detailing the treatment for other conditions. At present, the main focus of fibrosis clinics is treatment of the symptoms or symptoms, which tend to be non-specific, and hence it is difficult to discriminate treatment in fibrosis." - Anonymous Online Contributor

"Fibrin glue seems to be more appropriately used with surgery than with other treatments, particularly in combination with other treatment approaches. Randomized controlled trials of fibrin glue combined with other treatments for endoscopic pleurodesis are needed to determine the ideal combination of fibrin glue with other treatments and to determine whether this combination has any advantage over other therapies for this indication. Similarly, it is important to determine whether fibrin glue is preferable to a variety of other sclerosing agents in combination with surgery." - Anonymous Online Contributor

"Recent findings reports the highest frequency of abnormal fibrosis reported to date. The findings suggest that, to be more effective, screening programs need to be implemented in populations exposed to the same environmental risk factors as those studied in this study. Prospective studies are warranted to validate these findings and further explore their impact on clinical practice." - Anonymous Online Contributor

"While most studies using iva337 have a long track record, these patients received placebo. Results from a recent paper of one of the longest studies using iva337 (4 years) indicate that iva337 is highly effective in the relief of symptoms. The duration of the study did not appear to influence treatment outcomes. The improvement of symptoms of RA does not happen during a short period of time, but persists during the long term." - Anonymous Online Contributor