This trial is evaluating whether Atorvastatin 20mg will improve 3 primary outcomes and 2 secondary outcomes in patients with Liver Fibroses. Measurement will happen over the course of 48 weeks.
This trial requires 60 total participants across 2 different treatment groups
This trial involves 2 different treatments. Atorvastatin 20mg is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"Because fibrosis progresses even with the absence of external stimuli, we suggest that the process of fibrosis should be considered a pathological response to chronic physiological alterations." - Anonymous Online Contributor
"Fibrosis can be avoided by quitting smoking and stopping drinking alcohol, avoiding excessive prolonged heavy weight lifting and heavy lifting of any kind, and managing chronic pain and avoiding/eliminating any stressful or irritating events with prolonged exposure to them during an entire year. A high-intensity interval training is particularly useful in preventing excessive physical fatigue during the healing process. The ultimate goal of all rehabilitation is, however, to remove the root causes of the disease so these risk factors can be eliminated." - Anonymous Online Contributor
"The signs of fibroblast activation include increased production of extracellular matrix to maintain tissue damage, and may include the appearance of histologic scars. Signs of tissue destruction include the appearance of scar tissue (desmoid-type fibroma in the case of desmoid tumours), and scarring around the tumor." - Anonymous Online Contributor
"Fibrosis involves the progressive replacement of tissue by scar tissue and is a characteristic feature of chronic liver diseases (such as cirrhosis) and cancer. The origin of the term fibrosis comes from the Greek word "stin" meaning 'a band' or 'tendon' and the verb"" - Anonymous Online Contributor
"Over 80% will not develop fibrosis in their lifespan; however, an alarming proportion of men will need to take some form of antifibrotic therapy over the lifetime. Fibrosis has a significant impact on patients' health-related quality of life and on their willingness to continue with conventional therapy." - Anonymous Online Contributor
"This is the most comprehensive overview of treatments for fibrosis of the liver with a wide range of treatments. Current treatments are generally limited to alleviating the symptoms arising from liver disease rather than altering the underlying cause or pathology." - Anonymous Online Contributor
"While a number of studies have shown that atorvastatin can reduce the amount of plaques in human artery wall, the amount of this reduction is quite variable and does not translate into a reduction in the size of the plagues. Further research is needed to understand the optimal effects of atorvastatin on the vascular wall in order to better establish the potential use of this drug in the prevention of cardiovascular disease." - Anonymous Online Contributor
"Fibrosis is not only a debilitating disease state; it is also a significant prognostic factor for disease-related progression or the need for liver transplantation. The incidence, prevalence, severity, and prognostic significance of fibrosis are widely variable." - Anonymous Online Contributor
"About half of my patients get fibrosis at a relatively young age (<50 years); the remainder have it at a typical patient age of 75-80 years. This difference is significant since fibrosis carries a 5-year risk of developing pancreatico-islet autoimmunity, pancreatitis, or diabetes. There may be a benefit to screening for high-risk fibrosis patients earlier than 5 years of age." - Anonymous Online Contributor
"Fibrosis is the process by which scar tissue builds up in different organs by a process that is not yet understood. Researchers have been actively investigating [the factors affecting the process of scarring] to prevent or slow down fibrosis, which can cause organ dysfunction and eventually death." - Anonymous Online Contributor
"There have not. Research has progressed the knowledge of fibrosis. The treatment of fibrosis will hopefully continue to progress so the patients can get more options for treatment. (author, N." - Anonymous Online Contributor
"Atorvastatin 20mg given once daily was well tolerated, improved insulin sensitivity and other lipid parameters and reduced atherosclerotic coronary atherosclerosis. Future clinical studies are planned." - Anonymous Online Contributor