Euthyrox

Hypothyroidism, Comatose, euthyroid Goitre + 3 more
Treatment
5 FDA approvals
14 Active Studies for Euthyrox

What is Euthyrox

LevothyroxineThe Generic name of this drug
Treatment SummaryLevothyroxine is a synthetic form of the hormone thyroxine, which is normally produced by the thyroid gland. This medication is used to treat hypothyroidism, a condition where the thyroid gland doesn't produce enough of the hormones thyroxine (T4) and triiodothyronine (T3). Symptoms of hypothyroidism include fatigue, increased heart rate, depression, dry skin, constipation, weight gain, memory problems and sensitivity to cold. Levothyroxine helps to replace the missing hormones and is usually well-tolerated by patients. It is often prescribed in place of desiccated thyroid
Thyrolaris the brand name
Euthyrox Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thyrolar
Levothyroxine
1969
1177

Approved as Treatment by the FDA

Levothyroxine, also known as Thyrolar, is approved by the FDA for 5 uses including Hypothyroidism and thyrotropin dependent Thyroid cancer .
Hypothyroidism
Helps manage Hypothyroidism
thyrotropin dependent Thyroid cancer
Hypothyroidism
Helps manage Hypothyroidism
Malignant Neoplasms
euthyroid Goitre
Helps manage euthyroid Goitre

Effectiveness

How Euthyrox Affects PatientsLevothyroxine is a synthetic hormone which can help bring your T4 levels back up to normal if they are too low. It's important to take the right dose of levothyroxine, as too much or too little can lead to negative effects on your health such as affecting your growth, heart rate, bone density, and blood sugar levels. People with heart conditions should start on a lower dose than those without a heart condition. If you have diabetes, you should be monitored closely when starting, changing, or stopping levothyroxine as it may affect your blood sugar levels.
How Euthyrox works in the bodyLevothyroxine is a form of thyroid hormone that helps to replace what the body may be lacking if you have hypothyroidism. When taken, it increases metabolic rate and decreases TSH. It also helps to convert T4 into T3 which has a wide range of stimulatory effects on cell metabolism. At low doses, it has an anti-inflammatory effect, while at higher doses it can suppress the immune system. In the fetus and newborn, it helps with growth and development, while in adults it helps regulate brain function, food metabolism, and body temperature. Symptoms of thyroid deficiency that levothyroxine can relieve include slow

When to interrupt dosage

The suggested dosage of Euthyrox depends on the determined condition, such as Comatose, Edematous Fibrosclerotic Panniculopathy (Cellulite) and Adiposity. The measure is reliant upon the administration approach enumerated in the table beneath.
Condition
Dosage
Administration
Hypothyroidism
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Liquid - Intravenous, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Cellulite
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Liquid - Intravenous, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Adiposity
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Liquid - Intravenous, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
euthyroid Goitre
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Liquid - Intravenous, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Malignant Neoplasms
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Liquid - Intravenous, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Comatose
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Liquid - Intravenous, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous

Warnings

Euthyrox Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heart Attack
Do Not Combine
Thyrotoxicosis
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
There are 20 known major drug interactions with Euthyrox.
Common Euthyrox Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Levothyroxine.
Bendamustine
Major
The serum concentration of Bendamustine can be decreased when it is combined with Levothyroxine.
Berotralstat
Major
The serum concentration of Berotralstat can be decreased when it is combined with Levothyroxine.
Binimetinib
Major
The serum concentration of Binimetinib can be decreased when it is combined with Levothyroxine.
Bortezomib
Major
The serum concentration of Bortezomib can be decreased when it is combined with Levothyroxine.
Euthyrox Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 20mg/kg when taken orally. This can cause a condition similar to natural thyrotoxicosis. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, anxiety, diarrhea, cramps, sweating, rapid heartbeat, increased pulse and blood pressure, abnormal heart rhythms, trembling, sleeplessness, intolerance to heat, fever, and changes in menstrual cycle.

Euthyrox Novel Uses: Which Conditions Have a Clinical Trial Featuring Euthyrox?

Fifteen active clinical trials are being conducted to investigate the potential of Euthyrox in curbing Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism and Coma.
Condition
Clinical Trials
Trial Phases
euthyroid Goitre
0 Actively Recruiting
Hypothyroidism
5 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable
Comatose
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Cellulite
0 Actively Recruiting
Adiposity
5 Actively Recruiting
Not Applicable, Phase 4

Euthyrox Reviews: What are patients saying about Euthyrox?

5Patient Review
5/11/2022
Euthyrox for Underactive Thyroid
I really appreciate that this brand works for me because I haven't had luck with others in the past. The 75microgram dosage is perfect for me and I have zero side effects, which is amazing. The only downside is that I have to take two pills each morning because they don't make a pill in my exact dosage, so it's a little more expensive than it could be. But overall, this medication has been a lifesaver!
3.7Patient Review
9/7/2022
Euthyrox for Underactive Thyroid
This acts as a buffer and it's been working well for me, as long as I'm mindful of my diet. I don't have diabetes, just Hashimoto's. I wonder if the formula has changed in the last few months though. My diet hasn't changed, but I have been losing a couple extra pounds each month.
2Patient Review
4/6/2022
Euthyrox for A Progressive Disease of the Thyroid Gland
I experienced a whole host of negative side effects while taking this medication, including low thyroid levels, heart palpitations, extreme hair loss, fatigue, facial skin rash, low grade fevers, feeling cold, and histamine issues.
2Patient Review
6/4/2022
Euthyrox for A Progressive Disease of the Thyroid Gland
Walmart switched the brand of my medication to Euthyrox, and after taking it for several months at the same dosage, all of my previous symptoms returned and my TSH level skyrocketed. I would recommend avoiding this brand.
2Patient Review
7/2/2021
Euthyrox for Underactive Thyroid
I started taking this medication about a year ago when Walmart swapped my previous prescription to this without letting me know. I initially questioned the change but was told it was no big deal, that this drug was just as effective. However, since being on this medication I've gained a lot of weight and felt constantly bloated. I stopped taking it recently and switched back to my old meds, and already feel so much better.
1.7Patient Review
6/22/2021
Euthyrox for Underactive Thyroid
Every time my pharmacy changes my synthroid to euthyrox, my hormone levels get thrown off and I have to up my dosage. I do best on synthroid, and am okay on levothyroxine, but within weeks of going on euthyrox black circles form under my eyes, Insomnia, brain fog, extreme exhaustion, and weight gain occur. It may work for some people however every time my pharmacy has switched me it has done nothing but damage to my body.
1.7Patient Review
6/9/2021
Euthyrox for Underactive Thyroid
1.3Patient Review
9/6/2021
Euthyrox for Underactive Thyroid
I felt awful while taking this medication. I had increased sweating, bad body odor, vision problems, and headaches. I was only on the medication for 5 weeks before I stopped taking it due to the side effects.
1.3Patient Review
10/12/2021
Euthyrox for Underactive Thyroid
I had a really negative reaction to this medication. Within four months of taking it, every joint in my body started hurting badly. It was hard for me to function at work or even stay awake. I don't know why this medicine didn't work for me the way it's supposed to, but I'm glad I talked to my doctor and got switched back to the old levothyroxine.
1.3Patient Review
10/26/2021
Euthyrox for Serious Decrease in Thyroid Function
The Walmart pharmacy switched to this brand of levothyroxine, and within a few weeks my thyroid levels had dropped so low that my doctor had to increase the dosage. This didn't help much until I requested to be switched back to a different brand.
1Patient Review
1/5/2022
Euthyrox for Underactive Thyroid
I was changed to Euthyrox by Walmart pharmacy, and ended up in the ER as a result of critically low thyroid levels. This caused weight gain, insomnia, headaches, and more. I'm disgusted that they would make a deal with the drug company without caring about the consequences. We need to get this drug off the market and hold them accountable for their actions.
1Patient Review
11/5/2021
Euthyrox for Underactive Thyroid
The new, improved version of this drug that is made in Germany does not work well for me. I felt exhausted, my appetite decreased, and my digestion was not working properly.
1Patient Review
4/14/2022
Euthyrox for Thyroid Cancer
I was much better off on the old formula of this drug. The new one has caused so many problems like hair loss and infertility. It also makes me nauseous and my stomach burns. I feel it burning all the way down when I swallow it. How can pharmacists do this to people ?!?!?
1Patient Review
1/29/2022
Euthyrox for Thyroid Cancer
I had a really terrible experience with this medication. I was substituted by my Wal-Mart pharmacy and after six weeks, I felt like I was going crazy. Brain fog, no concentration, and it even strangely affected my prostate. But as soon as I went back to Levothyroxrine, I felt normal again within two days.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about euthyrox

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Euthyrox used for?

"This medication is also used to treat certain types of goiters (enlarged thyroid gland).

Levothyroxine is a medication doctors prescribe to treat an underactive thyroid, or hypothyroidism. Hypothyroidism occurs when the thyroid gland doesn't produce enough thyroid hormone. Low thyroid hormone levels can happen naturally, or they can result from damage to the thyroid gland from radiation or surgery. In addition to treating hypothyroidism, levothyroxine is also prescribed to people with goiters. A goiter is an enlarged thyroid gland."

Answered by AI

Does Euthyrox make you gain weight?

"This medication will not affect your weight once your thyroid levels are normal again. Euthyrox has a narrow therapeutic index, meaning that there is a fine line between taking too much or having too little."

Answered by AI

What are side effects of Euthyrox?

", skin rash, itching;, constant feeling of sadness or depression;

The person experiences the following: chest pain, irregular heartbeats, shortness of breath, headache, leg cramps, muscle pain or weakness, tremors, feeling nervous or irritable, trouble sleeping, increased appetite, feeling hot, weight loss, changes in menstrual periods, skin rash, itching, constant feeling of sadness or depression."

Answered by AI

Is Euthyrox the same as levothyroxine?

"Euthyrox is a medication used to treat an underactive thyroid, also known as hypothyroidism. This medication is available in the form of an oral tablet. The generic version of this drug is levothyroxine."

Answered by AI

Clinical Trials for Euthyrox

Image of Cleveland Clinic in Cleveland, United States.

Gluten Free Diet for Hashimoto's Disease

Any Age
All Sexes
Cleveland, OH
Hashimoto's thyroiditis is an autoimmune condition that reduces functioning of the thyroid gland and can lead to a substantial decline in quality of life for patients, with impacted patients often describing unremitting brain fog, fatigue/malaise and weight gain leading to difficulty functioning in their jobs and homes. It is the most common cause of hypothyroidism in the U.S. and affects up to 10% of the global population. The typical treatment for Hashimoto's is thyroid hormone replacement with medications such as levothyroxine. However, despite adequate treatment as defined by thyroid hormone levels within the reference range, up to 10% of patients will experience persisting symptoms which can dramatically impair quality of life. While various theories have been postulated for the residual symptoms, several studies indicate that they are related to the thyroid autoimmunity, specifically the autoantibodies that are made by the immune system in Hashimoto's thyroiditis in response to the thyroid (ie thyroid peroxidase \[TPO\], thyroglobulin \[Tg\] antibody \[AB\]) and the associated inflammation with the immune response. Removal of thyroid (ie total thyroidectomy) reduces levels of these thyroid antibodies and results in significant improvement in quality-of-life. However, thyroidectomy is an invasive procedure with potential for morbidity such as damage to the recurrent laryngeal (nerve that controls the vocal cords and thus speech), bleeding and infection, so there is interest in other more conservative modalities for lowering the inflammation and autoimmune burden in Hashimoto's thyroiditis. In an effort to identify a less invasive approach for reducing the levels of thyroid antibodies and inflammation, attention has moved to the intersection of Hashimoto's thyroiditis and the gut. Hashimoto's has a strong association with autoimmune disorders impacting the gastrointestinal tract, in particular celiac disease and non-celiac gluten sensitivity (NCGS). NCGS is a condition where there are intestinal and extra-intestinal symptoms associated the consumption of gluten but no presence of anti-tissue transglutaminase antibodies (anti-tTG) which define Celiac Disease. This connection between Hashimoto's thyroiditis and sensitivity to gluten appears to be not only genetic, as those with Celiac Disease/NCGS and Hashimoto's thyroiditis have common HLA haplotypes, but also at the level of the intestine with gut microbiome dysfunction.
Recruiting
Has No Placebo
Cleveland Clinic
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Novel Treatments for Hypothyroidism

18+
All Sexes
Farmington, CT
Hypothyroidism is a common condition, more frequent in females, associated with excess of cardiovascular risk and poor quality of life not completely abrogated by treatment with levothyroxine. There is an unmet need to define a safe, effective, and feasible regimen to be applied in large trials aimed at assessing levothyroxine/liothyronine combination therapy in patients living with hypothyroidism. To address this knowledge gap we propose a randomized, three-arm, double-blind, controlled, escalating dose parallel pilot study whose results will lay the foundation of large multicenter trial(s) able to demonstrate the effectiveness (or lack thereof) of levothyroxine/liothyronine combination therapy.
Phase 2 & 3
Recruiting
UConn HealthFrancesco Celi
Have you considered Euthyrox clinical trials? We made a collection of clinical trials featuring Euthyrox, we think they might fit your search criteria.Go to Trials
Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Estradiol Patch for Menopause

20 - 45
Female
Aurora, CO
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease. The purpose of this research is to study how the decrease in estrogen at menopause changes artery health and fat gain, and risk of disease in women as they age. The first aim in this study will determine whether short term and long term low estrogen levels in premenopausal women decreases artery function and whether this is related to an increase in fat in the stomach area. The second aim will determine whether the changes in artery health and body fat are related to changes in a pathway that breaks down an important amino acid called tryptophan. This pathway is thought to play a role in regulating the aging process. Therefore, the investigators will determine whether the decrease in artery health and the increase in body fat in the stomach region with low estrogen is related to changes in this pathway in the blood, in vascular cells and fat tissue. Because estrogen levels fluctuate in premenopausal women, the investigators will use an approach (intervention) that controls estrogen levels to address these aims. The investigators will use a medication that is typically used to treat endometriosis or uterine fibroids to lower estrogen levels and an estrogen patch to increase estrogen in some women. Some women will receive a patch that has no estrogen (called a placebo patch). The intervention period will be 20 weeks. The study will provide us with new knowledge on how low estrogen with menopause affects artery health and fat gain estrogen.
Phase 4
Recruiting
University of Colorado Anschutz Medical CampusKerrie Moreau, PhD
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Weight Loss for Obesity

18 - 70
All Sexes
Aurora, CO
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.
Recruiting
Has No Placebo
University of Colorado Anschutz
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