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AMG 193 + IDE397 for Solid Cancers
Study Summary
This trial tests the safety and effectiveness of two drugs for treating advanced MTAP-null tumors, incl. NSCLC.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- My cancer lacks MTAP and has no standard treatment available.My NSCLC lacks MTAP and has worsened after 1-2 treatments.My cancer has spread and cannot be cured with surgery or radiation.I do not have a digestive condition that prevents me from taking pills.I have untreated brain issues or spinal cord compression due to cancer.I have previously been treated with an MAT2A or PRMT5 inhibitor.I haven't had any major bowel or abdominal issues in the last 6 months.I can provide samples of my tumor, or I am willing to undergo a biopsy.My tests show I have a specific genetic change (MTAP loss).More than a quarter of my bone marrow has been exposed to radiation.Your disease can be measured according to specific guidelines.My organs are functioning well.I can swallow pills and will track my medication intake.You have specific heart or lung conditions that are listed in the study's guidelines.I haven't taken strong medication that affects liver enzymes recently.
- Group 1: Part 1: Dose Exploration of AMG 193 Combined With IDE397
- Group 2: Part 2: Dose Expansion of AMG 193 Combined With IDE397
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are individuals currently being recruited to take part in this experiment?
"Affirmative. Per the information on clinicaltrials.gov, this research project is currently enrolling subjects - first posted in August of 2023 and most recently updated a few weeks ago. 184 people have to be recruited from two seperate locations for participation in this trial."
How many participants are being enrolled in this research project?
"Affirmative. According to clinicaltrials.gov, this particular research project still requires volunteers and was first published on August 1st 2023. The most recent update was made on August 24th 2023 and 184 participants will need to be recruited from 2 sites in total."
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