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Metronomic Chemotherapy for Pediatric High-Risk Cancer (Metronomic Trial)
Metronomic Trial Summary
This trial studied the effectiveness of metronomic therapy given in the first-line setting to pediatric patients with high-risk solid tumors.
Metronomic Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowMetronomic Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2015 Phase 4 trial • 45 Patients • NCT02036424Metronomic Trial Design
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Who is running the clinical trial?
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- I will begin low-dose therapy within 6 weeks after my initial treatment.My cancer is one of the following: rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, or another soft tissue sarcoma.I have a solid tumor with known progression timeline.I have finished my initial cancer treatment.My primary cancer is currently in remission.I have a brain tumor.I can do most activities but may need help.My kidney function is normal, based on my creatinine levels.I have recovered from minor surgery for at least 7 days or major surgery for at least 28 days.My heart is strong, with a good pumping efficiency.I am using effective birth control during the study.My cancer has returned or stopped responding to treatment, or I have had another type of cancer.My cancer is not in remission.My cancer is one of the following: rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, or another soft tissue sarcoma.I have a solid tumor with known progression timeline.My kidney function is normal.I have recovered from minor surgery for 7 days or major surgery for 28 days.My heart is strong enough, meeting the required health standards.I have finished my initial cancer treatment.My primary cancer is currently in remission.I am between 1 and 30 years old.My white blood cell count is sufficient.Your condition is expected to worsen within the next 2 years, based on past information.I am between 1 and 30 years old.I can do most activities but may need help.My white blood cell count is healthy.I will begin continuous low-dose therapy within 6 weeks after my initial treatment.I am currently pregnant.I am a woman able to have children and have a negative pregnancy test.
- Group 1: Metronomic Therapy
- Approved for 20 Other Conditions - This treatment demonstrated efficacy for 20 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Bevacizumab been subject to previous research investigations?
"Currently, 1186 trials are running research on Bevacizumab with 246 of them in the third stage. Despite the high concentration of studies located in Philadelphia, Pennsylvania, there is a total number of 43963 locations examining this particular treatment."
Is it possible for me to participate in this clinical trial?
"In order to be accepted into this study, participants must have a solid tumor and fall in the 12 month - 31 year age range. A total of 20 individuals are being sought out for the experiment."
How many individuals have chosen to partake in this experiment?
"Affirmative. Clinicaltrials.gov indicates that this trial, which was first uploaded on July 1st 2014, is actively recruiting patients. To participate in the study, 20 individuals need to be recruited between two different sites."
What medical conditions has Bevacizumab been shown to effectively control?
"Bevacizumab is used to abate advanced forms of ovarian cancer that are resistant to platinum-based treatments. It has also been proven effective at managing malignant neoplasms, multiple sclerosis, and recurrent primary peritoneal cancer sensitive to platinum."
Are there any opportunities for enrollment in this trial currently?
"Affirmative. The clinicaltrial.gov database suggests that this medical trial is currently recruiting patients, having first been advertised on July 1st 2014 and updated most recently on May 13th 2015. It requires only 20 participants to be recruited across two sites."
What is the ultimate goal of this research endeavor?
"This long-term trial has the primary goal of determining safety and tolerability, measured by counting adverse events. Secondary objectives involve assessing patients' quality of life with PedsQL Quality of Life Scale, fatigue levels via PedsQL Fatigue Scale and pain experienced through Present Functioning Scale."
Are individuals aged 45 and above eligible to join this experiment?
"This trial is seeking out participants aged 12 Months to 31, with 517 trials available for those younger than 18 and 2298 for senior citizens."
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