Tau PET Imaging for Cognitive Impairment

Recruiting at 1 trial location

Age: 18+

Sex: Any

Trial Phase: Phase 2

Sponsor: Mayo Clinic

Disqualifiers: Pregnancy, Claustrophobia, Prolonged QT, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: Unknown

240 Participants Needed

Trial Summary

What is the purpose of this trial?

The researchers are trying to gather information and learn more about imaging tests in racially different people who are cognitively normal or have dementia.

Research Team

Neill R Graff-Radford, MD

Principal Investigator

Mayo Clinic

Eligibility Criteria

This trial is for African American adults aged 30 or older who have either normal cognitive function or dementia. They must be able to lie still for 20 minutes and not have conditions like a prolonged QT interval on an ECG, metal implants, pacemakers, or severe claustrophobia that would prevent MRI scans.

Inclusion Criteria

Subjects who have completed or are scheduled to undergo the neurological evaluation procedures described below.

I am an African American aged 30 or older.

Exclusion Criteria

I do not have any metal implants or a pacemaker that would prevent me from having an MRI.

I can't stay still lying down for 20 minutes.

You have a fear of enclosed spaces and cannot undergo scans.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging Tests

Participants undergo neuroimaging tests to gather information on tau positive scans

5 years

Follow-up

Participants are monitored for safety and effectiveness after imaging tests

4 weeks

Treatment Details

Interventions

• Tau PET scan

Trial Overview The study is examining the use of Tau PET scans in African Americans to understand more about brain imaging tests across different races in people with normal cognition or dementia.

Participant Groups

Group I: Normal control Experimental Treatment 1 Intervention

Cognitively normal volunteers

Group II: Mild Cogntive impairment Experimental Treatment 1 Intervention

Person with cognitive impairment that meet Peterson Criteria

Group III: Demented Experimental Treatment 1 Intervention

Patient's that meet dementia criteria

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+

National Institute on Aging (NIA)

Collaborator

Trials

1,841

Recruited

28,150,000+