Browse 42 Gabapentin Medical Studies Across 61 Cities
11 Phase 3 Trial · 91 Gabapentin Clinics
What Are Gabapentin Clinical Trials?
Gabapentin clinical trials are research studies that test the safety and effectiveness of a new medication or treatment. Gabapentin is a medication commonly used to treat seizures and nerve pain.
However, clinical trials can be studied to see if Gabapentin can be applied to treat other conditions such as anxiety disorders, Depression, and Migraines. Also, Bipolar disorder and chronic pain conditions such as fibromyalgia.
Why Is Gabapentin Being Studied in Clinical Trials?
Gabapentin is being studied in clinical trials for its possible uses in a variety of conditions and illnesses, including:
Gabapentin is already approved by the U.S. Food and Drug Administration (FDA) for treating seizures and pain relief. However, researchers are still studying Gabapentin in clinical trials to see if it is effective for other conditions.
It's generally prescribed for seizure disorders such as epilepsy. Gabapentin is also approved to treat nerve-related pain, such as the pain that sometimes follows shingles. However, further testing is needed to see if Gabapentin is effective for other conditions such as migraines, bipolar disorder, and chronic pain.
How Does Gabapentin Work?
Gabapentin works by binding to a specific site on voltage-gated calcium channels found in nerve cells. This action decreases the release of neurotransmitters from these cells, such as glutamate and the substance P.
Gabapentin has also been shown to bind to the α2δ subunit of voltage-gated calcium channels. This binding may be responsible for Gabapentin's analgesic effects. Gabapentin may help relieve pain by affecting how the body senses pain.
Gabapentin is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. However, more research needs to be tested to see how Gabapentin works in the brain to treat conditions such as seizures, pain relief, migraines, anxiety disorders, and depression.
What Are Some of The Breakthrough Clinical Trials Involving Gabapentin?
Gabapentin has shown promise in several clinical trials for various conditions. However, significant breakthroughs include the following studies:
2001: Gabapentin has also been studied as a treatment for migraine headaches. In one study, Gabapentin was found to be as effective as amitriptyline (a tricyclic antidepressant) in reducing the frequency of migraine headaches.
2002: Gabapentin has also been studied as a treatment for RLS. In one clinical trial, Gabapentin was shown to be more effective than a placebo in reducing the severity of RLS symptoms.
2004: For example, Gabapentin has been studied as a possible treatment for hot flashes in menopausal women. In one study, Gabapentin was shown to be more effective than a placebo in reducing the frequency and severity of hot flashes.
Who Are The Key Opinion Leaders On Gabapentin Clinical Trial Research?
Dr. Andrew Wilner. He has researched Gabapentin as a treatment for migraines, RLS, and other conditions. He is a board-certified internist, neurologist, and epilepsy specialist. He is also an Associate Professor of Neurology at the University of Tennessee Health Science Center in Memphis, TN.
Dr. Scott Fishman. He is the current vice president of the Department of Anesthesiology and Pain Medicine. He is also the Director of the Center for Advancing Pain Relief and a Professor at UC Davis. His research focuses on chronic pain, cancer management, and neuropathic pain treatment strategies.