Reviewed by Michael Gill, B. Sc.
23 Marijuana Clinical Trials Near Me
Top Hospitals for Marijuana Clinical Trials
Image of New York State Psychiatric Institute in New York.
New York State Psychiatric Institute
New York
2Active Trials
0All Time Trials for Marijuana
2021First Marijuana Trial
Image of Hartford Hospital in Connecticut.
Hartford Hospital
Hartford
2Active Trials
0All Time Trials for Marijuana
2021First Marijuana Trial
Top Cities for Marijuana Clinical Trials
Image of New York in New York.
New York
2Active Trials
New York State Psychiatric InstituteTop Active Site
Most Recent Marijuana Clinical Trials
Clinical Trial
Began Recruiting Date
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Top Treatments for Marijuana Clinical Trials
Treatment Name
Active Marijuana Clinical Trials
All Time Trials for Marijuana
First Recorded Marijuana Trial
Marijuana
2
2
2019
iTBS
1
1
2022
THC-dominant cannabis
1
1
2022
CRAFT-EP
1
1
2022
10 mg THC
1
1
2021

What Are Marijuana Clinical Trials?

Marijuana, scientifically known as Cannabis, is a plant historically used for its medicinal and hallucinogenic properties. Specifically, scientists have shifted their focus toward cannabidiol (CBD) and 9-tetrahydrocannabinol (THC), molecules with significant therapeutic value.

However, without control groups, homogenous study populations, and standardized dosing regimens, published marijuana research has yielded inconclusive results. Therefore, recent marijuana clinical trials have aimed to identify the most effective Cannabis strains for different ailments, the long-term effects of treatment, and new clinical uses for marijuana therapy.

Why Is Marijuana Being Studied Through Clinical Trials?

Humans produce endocannabinoids, hormones capable of regulating critical physiological processes, such as inflammation, blood pressure, and pain response. However, the molecules in marijuana can interact with the endocannabinoid receptors to alter the associated physiological processes.

Therefore, marijuana clinical trials are highly valuable to patients unable to tolerate the adverse effects of allopathic medicines. Examples of conditions in which marijuana may be preferred to conventional therapies include pain management in cancer patients, nausea treatment in chemotherapy patients, and management of muscle spasms in multiple sclerosis patients.

What Are The Available Types of Marijuana Treatment?

Medicinal marijuana products may be synthetic or naturally derived and are available in three primary forms. Isolated forms contain only one type of cannabinoid, while full-spectrum forms include a more significant fraction of marijuana’s Phyto complex. Like full-spectrum forms, broad-spectrum products contain several cannabinoids but exclude tetrahydrocannabinol due to its hallucinogenic effects.

Oils and capsules are the most common forms of medicinal marijuana. However, there are various dosage forms and strengths available. These forms include topical creams, mouth sprays, and lozenges. The dosage form and strength differ depending on the clinical indication for marijuana therapy.

What Are Some Recent Breakthrough Clinical Trials For Marijuana?

There have been several ground-breaking discoveries made through marijuana clinical trial research, including the following:

2021: The Use of Marijuana For Its Anti-inflammatory Properties in COVID Patients: Cannabinoids exhibited significant activity at the endocannabinoid type II receptors and the peroxisome proliferator-activated receptor γ. In turn, this activity promoted anti-inflammatory responses in the body. When administered in COVID patients, marijuana treatment effectively manages respiratory inflammation caused by viral infection.

2022: The Synergism of Marijuana’s Phytocomplex Contributes To Its Clinical Efficacy: Though CBD and THC are the focus of many clinical trials, researchers found that the spectrum of cannabinoids in marijuana had a synergistic effect which contributed significantly to its clinical effects. Therefore, broad-spectrum products were more beneficial than isolated forms of medical marijuana.

Who Are Some Of The Key Opinion Leaders Conducting Marijuana Clinical Trial Research?

Dr. Raphael Mechoulam is a renowned marijuana researcher responsible for the discovery and isolation of THC. His work at the Hebrew University of Jerusalem has formed the foundation of countless marijuana studies.

Dr. Richard Huntsman is a pediatrician currently leading a research team studying the effect of marijuana therapy in pediatric patients with refractory epileptic encephalopathy. This research can potentially mitigate the development of severe brain dysfunction associated with refractory epileptic encephalopathy.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 20th, 2021

Last Reviewed: October 26th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References1 Hartzler B, Lyon AR, Walker DD, Matthews L, King KM, McCollister KE. Implementing the teen marijuana check-up in schools-a study protocol. Implement Sci. 2017 Aug 10;12(1):103. doi: 10.1186/s13012-017-0633-5. https://pubmed.ncbi.nlm.nih.gov/287972702 Gilman JM, Schuster RM, Potter KW, Schmitt W, Wheeler G, Pachas GN, Hickey S, Cooke ME, Dechert A, Plummer R, Tervo-Clemmens B, Schoenfeld DA, Evins AE. Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022 Mar 1;5(3):e222106. doi: 10.1001/jamanetworkopen.2022.2106. https://pubmed.ncbi.nlm.nih.gov/35302633