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Behavioural Intervention

Cannabis Abstinence for Cannabis Use Disorder

N/A

Recruiting

Led By Brenden Tervo-Clemmens, PhD

Research Sponsored by University of Minnesota

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Male and female adolescents between the ages of 15 and 18 (inclusive)

Native English speaker

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, weeks 1,2,3,4,5 and 6

Awards & highlights

Study Summary

This trial will study changes in brain activity associated with cannabis abstinence in teens. Through fMRI scans & behavioral tests, it'll identify changes in reward-based brain activity & impulsivity. The aim is to better understand the effects of cannabis abstinence.

Who is the study for?

Adolescents aged 15-18 with Cannabis Use Disorder (CUD) who use cannabis at least 5 days a week and those without any history of cannabis use. Participants must be native English speakers, have stable psychotropic medication if applicable, and commit to 8 study visits over about two months. They cannot have other substance abuse disorders, daily nicotine use, MRI contraindications like metal implants or claustrophobia, or serious medical/psychiatric conditions.Check my eligibility

What is being tested?

The trial is testing the effects of a six-week period where adolescents with CUD either abstain from cannabis use under supervision (CB-Abst group) or continue their usual consumption without abstinence requirements (CB-Mon group). The control group has no history of cannabis use. Brain function will be measured using fMRI scans during tasks related to reward processing and impulsivity.See study design

What are the potential side effects?

Since this trial involves behavioral interventions rather than medications, traditional side effects are not expected. However, participants in the abstinence group may experience withdrawal symptoms such as irritability, mood changes, sleep difficulties, cravings for cannabis or physical discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 15 and 18 years old.

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I am a native English speaker.

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I am not currently using antipsychotic medications nor do I have active psychosis.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, weeks 1,2,3,4,5 and 6

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, weeks 1,2,3,4,5 and 6

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, weeks 1,2,3,4,5 and 6 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Brain activation during Monetary Incentive Delay Task (reward processing)

Brain connectivity during resting-state functional neuroimaging protocol

Secondary outcome measures

Self-reported Impulsivity via UPPS-P scale

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: CB-MONExperimental Treatment1 Intervention

adolescents ages 15-18 years old with CUD use randomized to CB-Mon

Group II: CB-AbstExperimental Treatment1 Intervention

adolescents ages 15-18 years old with CUD use randomized to CB-Abst

Group III: controlActive Control1 Intervention

Age- and sex-matched adolescents with no lifetime history of cannabis use will also complete the protocol.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor

1,381 Previous Clinical Trials

1,551,220 Total Patients Enrolled

Brenden Tervo-Clemmens, PhDPrincipal InvestigatorUniversity of Minnesota

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the current protocol of this experiment encompass individuals aged 50 and up?

"In order to participate in this research, prospective participants must be aged 15-18. There are 17 studies for minors and 46 specifically targeting individuals of advanced age groups."

Answered by AI

Is enrollment for this research program still ongoing?

"Clinicaltrials.gov reveals that this research project is no longer recruiting participants; the trial was first posted on January 15th 2024 and its last update occurred on November 3rd 2023. Nevertheless, there are 100 other studies presently seeking test subjects."

Answered by AI

Is participation in this investigation open to me?

"This clinical trial, which is recruiting 64 patients in total, requires that participants have a diagnosed cannabis use disorder and can be no older than 18 or younger than 15."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

2024. "Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06124846.