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Cannabinoid

40mg THC for Cannabis Use

Phase 2

Recruiting

Led By Ryan McLaughlin, PhD

Research Sponsored by Washington State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up this outcome will be computed from measures collected at baseline (i.e., during the testing session but before treatment) and at the end of the testing session (i.e., after memory tests are complete).

Awards & highlights

Study Summary

This trial examines how cannabis affects memory. Eligible participants will take tests & wear a wristband. They'll inhale vapor with/without THC & complete tests. Researchers hypothesize that those inhaling cannabis will perform worse on memory tests than those inhaling placebo.

Who is the study for?

This trial is for individuals who have used cannabis at least once a week for over a year and are willing to abstain from using it on the day of testing. Participants will be screened for drug use, wear an Empatica E4 wristband, and provide saliva samples.Check my eligibility

What is being tested?

The study tests how different amounts of THC in cannabis (20mg or 40mg) versus placebo affect memory functions. Participants will undergo various memory tests after inhaling vaporized cannabis or placebo provided by NIDA.See study design

What are the potential side effects?

Potential side effects include impairment in different types of memory such as prospective, verbal, visuospatial, source, working memory, false memories and temporal order recall. Other effects may include changes in mood, anxiety levels and stress.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ this outcome will be assessed during the testing session, within 90 min post-treatment.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~this outcome will be assessed during the testing session, within 90 min post-treatment.

This trial's timeline: 3 weeks for screening, Varies for treatment, and this outcome will be assessed during the testing session, within 90 min post-treatment. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Bell Ring Prospective Memory Test

Memory

Delayed Visuospatial Memory

+15 more

Secondary outcome measures

Anxiety Rating Change Score (Baseline to Mid-testing)

Anxiety Rating Change Score (Baseline to Post-testing)

Anxiety Rating Change Score (Baseline to Post-treatment)

+20 more

Other outcome measures

Cannabis Consumption Patterns

Drug Screen

Electrodermal Activity

+4 more

Trial Design

3Treatment groups

Experimental Treatment

Placebo Group

Group I: 40mg THCExperimental Treatment1 Intervention

Participants will inhale vapor from .34 grams of cannabis containing 11.86% THC (40mg THC total).

Group II: 20mg THCExperimental Treatment1 Intervention

Participants will inhale vapor from .17 grams of cannabis containing 11.86% THC (20mg THC total).

Group III: PlaceboPlacebo Group1 Intervention

Participants will inhale vapor from a placebo product.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Cannabis

2014

Completed Phase 3

~810

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Washington State UniversityLead Sponsor

101 Previous Clinical Trials

56,558 Total Patients Enrolled

Ryan McLaughlin, PhDPrincipal InvestigatorWashington State University

Carrie CuttlerPrincipal InvestigatorWashington State University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What objective is this trial striving to achieve?

"The primary goal of this trial is to measure the Source Memory Test - Free Recall results over a 90 minute period post-treatment. Secondary outcomes include Post-testing Intoxication Rating 5, Snack Consumption Type and Mood Rating Change Score (Baseline to Post-testing)."

Answered by AI

Are there any remaining opportunities to enroll in this clinical trial?

"Affirmative. Clinicaltrials.gov data suggests that this scientific trial, which was initially posted on August 21st 2023, is still recruiting individuals for participation. 156 patients need to be found at a single clinical site."

Answered by AI

What ill effects might a 20mg dose of THC bring about?

"There is some clinical evidence regarding 20mg THC's safety, so we gave it a score of 2. Unfortunately, no efficacy data exists to substantiate its effectiveness at this time."

Answered by AI

What is the sample size of this clinical investigation?

"Affirmative. The information hosted on clinicaltrials.gov reveals that this trial, which was initially registered on August 21st 2023, is currently enrolling participants. 156 volunteers must be recruited from 1 site for the study to reach completion."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Acute Effects of Cannabis on Everyday Life Memory

Ryan Mclaughlin 2023. "Acute Effects of Cannabis on Everyday Life Memory". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05488509.