Long-Term Follow-Up for Prostate Cancer

Age: Any Age
Sex: Male
Trial Phase: Academic
Sponsor: City of Hope Medical Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to evaluate the effectiveness of long-term follow-up for prostate cancer patients after surgery. The follow-up includes a health check and education plan starting one year post-surgery. It seeks to understand the long-term effects on quality of life and to support future health interventions. Men who underwent prostate cancer surgery at City of Hope, are at least a year post-surgery, and have stable disease without cancer recurrence may be suitable candidates. The study excludes those with a history of other urologic cancers or those currently undergoing certain hormone therapies. As an unphased study, this trial offers a unique opportunity to contribute to research that could enhance future patient care.

Do I need to stop my current medications for this trial?

The trial does not specify if you need to stop taking your current medications, but you cannot be on testosterone replacement or androgen deprivation therapy.

What prior data suggests that this long-term follow-up is safe for prostate cancer patients?

Research has shown that long-term follow-up for prostate cancer patients is generally safe. Studies have examined patients' health for many years after surgery. Some results indicate a higher chance of urinary or sexual problems post-surgery. Specifically, one study found that the risk of these issues was more than seven times higher for those who had surgery compared to others.

However, the long-term follow-up itself, which includes regular health check-ups and education, does not introduce any new risks. Instead, it helps track and manage existing health problems. Thus, participating in a long-term follow-up program is considered safe and well-tolerated.12345

Why are researchers excited about this trial?

Researchers are excited about the long-term follow-up protocol for prostate cancer because it offers a comprehensive approach to survivorship care that isn't typically part of standard treatment. Unlike current options that focus primarily on initial treatment and recovery, this protocol emphasizes ongoing health evaluation and education starting one year after surgery. By providing patients with a written survivorship care plan, it empowers them to take charge of their long-term health, potentially improving outcomes and quality of life. This proactive, personalized care strategy marks a significant shift from the traditional focus on immediate post-surgical care.

What evidence suggests that this trial's treatments could be effective for prostate cancer?

Research has shown that regular long-term check-ups are crucial for prostate cancer survivors. These check-ups detect any returning cancer and manage side effects, while also improving patients' quality of life. Survival rates for prostate cancer are very high, with 98% of patients living at least 10 years and 95% living at least 15 years. This highlights the need to understand survivors' needs. In this trial, participants will undergo long-term follow-up and receive a written survivorship care plan, which personalizes and focuses follow-up care on the patient. Although the exact benefits of survivorship care plans are still under study, they are designed to enhance the overall care experience for survivors.678910

Who Is on the Research Team?

SA

Saro Armenian, DO

Principal Investigator

City of Hope Medical Center

Are You a Good Fit for This Trial?

This trial is for prostate cancer survivors who had surgery at least a year ago, are currently free of cancer or have stable disease, and haven't had radiation or chemo for prostate cancer. Men with other urologic cancers or those on hormone therapies can't join.

Inclusion Criteria

My cancer has not come back or spread after treatment.
I have prostate cancer and no history of other urologic cancers.
I have been diagnosed with prostate cancer.
See 5 more

Exclusion Criteria

I am currently on testosterone replacement or androgen deprivation therapy.
Treatment for another noncutaneous cancer within the past 2 years

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Post-Surgery

Participants undergo definitive surgical therapy for prostate cancer

Immediate post-surgery

Long-term Follow-up

Participants receive a written survivorship care plan including comprehensive health evaluation and health education beginning 1 year post surgery

Up to 10 years

What Are the Treatments Tested in This Trial?

Interventions

  • Educational Intervention
  • Laboratory Biomarker Analysis
  • Long-term Follow-up
  • Quality-of-Life Assessment
  • Questionnaire Administration
Trial Overview The study looks at the effectiveness of long-term follow-up care in men after prostate cancer surgery. It includes educational materials, regular questionnaires, lab tests to check health markers, and assessments of life quality over time.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Supportive Care (long-term follow-up)Experimental Treatment5 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

City of Hope Medical Center

Lead Sponsor

Trials
614
Recruited
1,924,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Citations

Achieving optimal delivery of follow-up care for prostate ...Long-term follow-up guidelines have only recently been developed to inform approaches to this phase of care for the prostate cancer population.
Addressing Follow-Up Gaps in Prostate Cancer ...Regular follow-up is critical for prostate cancer survivors to detect recurrences, manage side effects, and improve quality of life.
Prostate cancer survivorshipThe current 10- and 15-year survival rates of 98% and 95%, respectively, further emphasize the importance of understanding the needs of PCa survivors. PCa is ...
A Tailored Electronic Survivorship Care Plan for Prostate ...Survivorship care plans (SCPs) aim to enhance patient-centered follow-up, yet their effectiveness remains unclear, especially for PCa survivors.
Navigating Pathways in Prostate Cancer SurvivorshipThis review explores the complex landscape of prostate cancer survivorship, with a focus on demographic disparities, barriers to care, symptom burden, and ...
6.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/39509091/
Long-Term Adverse Effects and Complications After ...The 12-year hazard risk of urinary or sexual complications was 7.23 times greater for those with prostatectomy (95% CI, 5.96-8.78; P < .001) and ...
Fifteen-Year Outcomes after Monitoring, Surgery, or ...After median follow-up of 15 years, 45 patients (2.7%) had died of prostate cancer: 17 (3.1%) in the active-monitoring group, 12 (2.2%) in the ...
Long-Term Outcomes in Patients Using Protocol-Directed ...The 10-year incidence of metastasis or prostate cancer mortality were 1.4% and 0.1%, respectively. There was no significant difference in ...
Long-term safety outcomes of 177Lu-PSMA-617 in patients ...It is important to further characterize long-term safety outcomes in 177 Lu-PSMA-617–treated patients, with particular regard to potential treatment-related ...
Long-Term Adverse Effects and Complications After ...This cohort study assesses the long-term adverse effects and complications of prostate cancer treatment in treated patients compared with a ...
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