Metformin for Prostate Cancer and Metabolic Syndrome
(PRIME Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently taking metformin or other diabetic medications, or have taken them within 28 days before joining the trial.
What data supports the effectiveness of the drug Metformin for prostate cancer?
Some studies suggest that Metformin might have beneficial effects on prostate cancer by potentially reducing the development of more aggressive forms of the disease. However, other research indicates that Metformin use does not significantly lower the risk of being diagnosed with prostate cancer.12345
Is metformin safe for humans?
How does the drug Metformin differ from other treatments for prostate cancer and metabolic syndrome?
What is the purpose of this trial?
This trial tests if metformin can help men with advanced prostate cancer on ADT by reducing the risk and severity of metabolic syndrome. Metformin helps control blood sugar by improving how the body uses insulin. Metformin is the most used drug for type 2 diabetes and has shown potential anti-cancer effects in various studies.
Research Team
Bernie Eigl, MD
Principal Investigator
British Columbia Cancer Agency
Nawaid Usmani, MD
Principal Investigator
University of Alberta
Eligibility Criteria
Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive metformin or placebo alongside androgen deprivation therapy for 18 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants are assessed for overall survival and other long-term outcomes
Treatment Details
Interventions
- Metformin
- Placebo Oral Tablet
Metformin is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
Find a Clinic Near You
Who Is Running the Clinical Trial?
Canadian Urologic Oncology Group
Lead Sponsor
BC Cancer Foundation
Collaborator
British Columbia Cancer Agency
Collaborator
Prostate Cancer Canada
Collaborator