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Cannabis Effects on Driving Performance (ADCUF Trial)

N/A
Waitlist Available
Led By Christine Wickens, PhD
Research Sponsored by Centre for Addiction and Mental Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Use of smoked cannabis for recreational purposes on up to 2 occasions per week or 5+ occasions per week but on no more than 5 days per week
Holds a class G or G2 Ontario driver's licence (or equivalent from another jurisdiction) for at least 12 months
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one hour after cannabis exposure
Awards & highlights

ADCUF Trial Summary

This trial will study the effects of cannabis on driving in young vs. middle-aged drivers who are occasional or frequent users of cannabis.

Who is the study for?
This trial is for occasional or frequent cannabis users aged 19-25 or 35-45 with a valid driver's license. Participants must not use alcohol or drugs other than prescribed ones before sessions and live in the Toronto area. Pregnant women, those with certain health conditions, and regular users of brain-affecting meds cannot join.Check my eligibility
What is being tested?
The study examines how cannabis affects simulated driving performance in young versus middle-aged drivers. It compares the effects between occasional and frequent cannabis users using placebos as controls to understand age-related differences in impairment.See study design
What are the potential side effects?
While specific side effects are not listed for this trial, common side effects from cannabis may include altered senses, mood changes, impaired body movement, difficulty thinking and problem-solving, impaired memory, and an increased risk of accidents.

ADCUF Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I use smoked cannabis recreationally, up to 2 times a week or 5+ times but not every day.
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I have had a full driver's license for at least 12 months.
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I can avoid alcohol for 2 days and cannabis for 3 days before tests.
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I am between 19-25 or 35-45 years old.
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I am between 19-25 or 35-45 years old.
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I have had a full or intermediate driver's license for at least a year.
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I use cannabis recreationally, but not more than 5 days a week.

ADCUF Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one hour after cannabis exposure
This trial's timeline: 3 weeks for screening, Varies for treatment, and one hour after cannabis exposure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Standard deviation of lateral position
Secondary outcome measures
Blood concentration of 11-hydroxy-tetrahydrocannabinol (11-OH-THC)
Blood concentration of carboxy-tetrahydrocannabinol (THC-COOH)
Blood concentration of delta-9-tetrahydrocannabinol (THC)
+15 more

ADCUF Trial Design

2Treatment groups
Experimental Treatment
Group I: Age group 35 to 45Experimental Treatment2 Interventions
Participants will complete two sessions: one where they drive the simulator before and after smoking a placebo cannabis cigarette (<1% THC), the other where they drive the simulator before and after smoking an active cannabis cigarette (15% ± 5% THC).
Group II: Age group 19 to 25Experimental Treatment2 Interventions
Participants will complete two sessions: one where they drive the simulator before and after smoking a placebo cannabis cigarette (<1% THC), the other where they drive the simulator before and after smoking an active cannabis cigarette (15% ± 5% THC).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebos
2019
Completed Phase 4
~2030
Cannabis
2014
Completed Phase 3
~810

Find a Location

Who is running the clinical trial?

Centre for Addiction and Mental HealthLead Sponsor
355 Previous Clinical Trials
81,116 Total Patients Enrolled
Bernard Le Foll, MD, PhDStudy DirectorCentre for Addiction and Mental Health
12 Previous Clinical Trials
234 Total Patients Enrolled
Christine Wickens, PhDPrincipal InvestigatorCentre for Addiction and Mental Health

Media Library

Cannabis Clinical Trial Eligibility Overview. Trial Name: NCT04325958 — N/A
Cannabis Research Study Groups: Age group 19 to 25, Age group 35 to 45
Cannabis Clinical Trial 2023: Cannabis Highlights & Side Effects. Trial Name: NCT04325958 — N/A
Cannabis 2023 Treatment Timeline for Medical Study. Trial Name: NCT04325958 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research have an age cap of 85 years or younger?

"This research study is only available to those between 19 and 45 years old."

Answered by AI

Could I possibly qualify for participation in this experiment?

"This research study is in search of 128 volunteers aged between 19 and 45 who use cannabis, either recreationally or for medical reasons. Moreover, these patients must have held a G-class driver's licence from Ontario (or a similar license from another region) for at least one year and be willing to abstain from alcohol consumption 48 hours prior to the test sessions as well as 72 hours without any cannabis. Furthermore they should reside within the Toronto metropolitan area - which may extend to Greater Toronto Area if recruitment becomes difficult - or can stay with family/friends during the trial period."

Answered by AI

Does this trial constitute a groundbreaking medical advance?

"In 2015, Jazz Pharmaceuticals sponsored the pioneering trial of Cannabis; this initial study involved 200 participants. Subsequent Phase 2 and 3 drug approval trials led to 31 active studies in five nations across 32 cities today."

Answered by AI

Are there any spots available to join this medical study?

"Unfortunately, this research project is not presently looking for volunteers. According to records from clinicaltrials.gov, the original post was on August 1st 2022 and it has since then been updated lastly on June 23rd of that same year. There are 125 separate medical trials enrolling patients with cannabis at present and 31 active studies recruiting individuals who use Cannabis products."

Answered by AI

What precedent exists regarding Cannabis research?

"Presently, there are 31 dynamic research studies examining Cannabis with 3 of these trials in the latter stages. Although most of these investigations are located in Hartford, Connecticut, across 46 distinct sites participants can sign up for a clinical trial involving Cannabis."

Answered by AI

How many individuals are eligible to join this medical experiment?

"At present, this clinical trial is no longer seeking participants. Initially posted on August 1st 2022, it was last updated on June 23rd of the same year. If you are searching for alternative studies, there are currently 125 medical trials related to cannabis with 31 actively recruiting patients."

Answered by AI

Who else is applying?

What state do they live in?
Idaho
How old are they?
18 - 65
What site did they apply to?
Centre for Addiction and Mental Health
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Centre for Addiction and Mental Health: < 48 hours
Average response time
  • < 2 Days
~85 spots leftby Mar 2027