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Vitamin

Vitamin C for Insulin Resistance

Phase 1 & 2
Recruiting
Led By Seth Holwerda, PhD
Research Sponsored by University of Kansas Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.
Middle-aged: 35-65 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 120 minutes
Awards & highlights

Study Summary

This trial is testing whether or not ascorbic acid (vitamin C) can help improve blood vessel function in obese adults with insulin resistance. The goal is to see if it can help reduce blood pressure, which is a risk factor for cardiovascular disease.

Who is the study for?
This trial is for obese adults aged 35-65 with insulin resistance. Participants must not be taking statins, antihypertension meds, or have a history of heart or vascular disease. They should stop vitamin C/E and omega-3 supplements two weeks before the study.Check my eligibility
What is being tested?
The study tests how well Vitamin C (ascorbic acid solution) can improve blood vessel function in comparison to saline in people with insulin resistance. It aims to see if Vitamin C can lower high blood pressure by improving vascular health.See study design
What are the potential side effects?
Potential side effects from ascorbic acid may include digestive discomfort, such as stomach cramps or diarrhea, and possibly an increased risk of kidney stones if taken in large doses over long periods.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am willing to stop taking vitamin C, E, or omega-3 supplements 2 weeks before.
Select...
I am between 35 and 65 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~120 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 120 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Efficacy of infusion of ascorbic acid

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Ascorbic acid infusionActive Control1 Intervention
Ascorbic acid solution (American Regent Laboratories Inc.) will be obtained from the KU Investigational Pharmacy located in the University of Kansas (KU) Clinical Research Center where studies will take place. A priming bolus of 0.06 g ascorbic acid/kg fat free mass (FFM) dissolved in 100 mL of saline will be infused intravenously at 5 mL/min for 20 minutes, followed immediately by a "drip-infusion" of 0.02 g/kg FFM dissolved in 30 mL of saline administered over 2 hours at 0.5 mL/min.
Group II: Placebo infusionPlacebo Group1 Intervention
Saline will be administered over 2 hours

Find a Location

Who is running the clinical trial?

University of Kansas Medical CenterLead Sponsor
461 Previous Clinical Trials
169,134 Total Patients Enrolled
Seth Holwerda, PhDPrincipal Investigator - University of Kansas Medical Center
University of Kansas Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the capacity for inclusion in this clinical trial?

"Correct. The clinicaltrials.gov database indicates that this study is currently enrolling 23 individuals at one site, and was first posted on June 17th 2021 with the last update being March 10th 2022."

Answered by AI

Is it currently possible to join this clinical trial?

"Affirmative. Records on clinicaltrials.gov specify that the trial is currently seeking participants, with an initial post date of June 17 2021 and a recent update made on March 10 2022. The clinical experiment will accept 23 subjects from 1 centre."

Answered by AI

What medical conditions warrant the use of Ascorbic acid infusion?

"Vitamin A deficiency is typically treated with an infusion of ascorbic acid. This same form of treatment can also prove beneficial in addressing catarrh, further vitamin deficiencies, and even supplementary supplementation."

Answered by AI

Is it feasible for me to become a participant of this research?

"For this trial, 23 volunteers aged 35 to 65 with hypertension are being sought. Furthermore, those interested must be able to forgo the use of vitamin C or E supplements and omega-3 fatty acids two weeks prior; furthermore they have to fall into either the obese (BMI above 30 m/kg2) or middle-aged categories (35 -65 years)."

Answered by AI

Is the demographic of this research study limited to those over 60 years old?

"This trial only admits patients aged between 35 and 65, but there are 103 studies for younger people and 1114 studies that accept seniors."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
Seth Holwerda PhD 2021. "Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04715022.
All > Hypertension
~6 spots leftby Apr 2025
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