Reviewed by Michael Gill, B. Sc.
Image of University of Cincinnati in Cincinnati, United States.
Phase-Based Progress Estimates

Treatment Arm (1)for Cognitive Decline

All Sexes
Sickle cell disease (SCD) is a common, inherited blood disorder that primarily affects people of African Ancestry. It has a lot of complications including neurological complications. The neurological complications of SCD are particularly devastating and lead to cognitive decline even in the absence of overt brain injury. In such cases, it is thought that inflammation in the brain maybe partly responsible for the cognitive decline. The main reasons for this research study are to see 1) how safe and 2) how well minocycline works to try to stop/reverse cognitive decline in people with SCD. People with SCD are at risk for changes in their brain over time that can cause problems with learning, memory, and attention. Part of the reason for this is inflammation within the brain. Minocycline may be able to stop these brain changes by stopping this brain inflammation. Minocycline is a second-generation tetracycline antibiotic that has been shown to both inhibit neuroinflammation and improve cognitive function in a variety of neurodegenerative and psychiatric disorders but has not yet been studied in SCD. We are proposing here, a pilot double-blinded, randomized controlled trial to examine the tolerability and early efficacy of minocycline in adults with SCD at two dosing regimens (200 mg and 300 mg daily) versus placebo over one year. Participants will undergo a neuropsychological exam using the NIH Toolbox Cognition Battery at both study enrollment and exit (after one year) to assess for changes/stability of cognition. Participants will receive monthly phone calls/text messages to assess for adverse events and will be seen every three months for pill counts and routine laboratory monitoring. The primary outcome will be a comparison of adverse events across the two dosing strategies versus placebo. Early evidence for cognitive benefit will also be assessed from the results of the NIH Toolbox.
Phase 1
Waitlist Available
University of Cincinnati
25 Mci Clinical Trials Near Me
Top Hospitals for Mci Clinical Trials
Image of University of Virginia in Virginia.
University of Virginia
7Active Trials
4All Time Trials for Mci
2015First Mci Trial
Top Cities for Mci Clinical Trials
Image of New York in New York.
New York
48Active Trials
Memorial Sloan Kettering Cancer CenterTop Active Site
Mci Clinical Trials by Phase of Trial
Phase < 1 Mci Clinical Trials
13Active Mci Clinical Trials
13Number of Unique Treatments
15Number of Active Locations
Cognitive TrainingReal LED InterventionExperimental: Nitrate-containingPramlintide challenge testMCI-activeMecamylamine ChallengeNicotinamide ribosideMemantine
Mci Clinical Trials by Age Group
< 18 Mci Clinical Trials
3Active Mci Clinical Trials
2-octyl cyanoacrylateGemcitabineUltrasound-guided pudendal nerve block (PNB)