Mind-Body Training for Mild Cognitive Impairment
(iMBT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether an online mindfulness program can help individuals with early memory concerns, who are at risk for Alzheimer's, improve focus and reduce mind-wandering. Participants will follow either an 8-week mindfulness program (Internet-based Mindfulness-Based Stress Reduction, or iMBSR) or a lifestyle education program (Internet-based Lifestyle Education, or iLifeEd), both completed online at their own pace. It suits those aged 50 or older who notice a decline in memory sharpness but have no diagnosed memory disorders. As an unphased trial, this study provides a unique opportunity to explore innovative approaches to memory improvement without the constraints of traditional clinical trial phases.
Will I have to stop taking my current medications?
The trial requires that participants do not use medications that significantly alter brain activity. If your current medications affect brain activity, you may need to stop taking them to participate.
What prior data suggests that these internet-based programs are safe for adults at-risk for Alzheimer's disease?
Research shows that mindfulness-based stress reduction programs, such as the online iMBSR being tested, are generally safe. Past studies have found these programs improve several health aspects without causing major side effects. Participants often report greater satisfaction with daily activities and improvements in mental well-being.
Mindfulness practices in iMBSR typically include meditation, body scans, and gentle movements. Most people, including older adults, find these activities easy to perform. Although some studies found no significant improvement in thinking skills, they also reported no harm.
In summary, the mindfulness-based approach under study is considered safe based on past research. Participants usually manage it well and may experience benefits like improved mood and increased satisfaction with daily life.12345Why are researchers excited about this trial?
Researchers are excited about Internet-based Mindfulness-Based Stress Reduction (iMBSR) for mild cognitive impairment because it offers a unique approach that emphasizes mindfulness practices delivered digitally. Unlike traditional treatments that may involve medications or in-person therapy, iMBSR allows participants to engage in mindfulness exercises like body scans and meditations at their own pace through an online platform. This flexibility and accessibility can be particularly beneficial for individuals with busy schedules or mobility issues. Additionally, the program fosters a sense of community and support, which can enhance the overall experience and effectiveness of the intervention.
What evidence suggests that this trial's treatments could be effective for mild cognitive impairment?
Research has shown that mindfulness-based stress reduction (MBSR) can enhance thinking skills in older adults. In this trial, participants in the Internet-based Mindfulness-Based Stress Reduction (iMBSR) arm will engage in online mindfulness exercises. Studies have found that these programs can slow memory and thinking problems and improve mental health issues like anxiety and depression. People with mild cognitive impairment, who often struggle with complex tasks, experienced better attention and memory after practicing MBSR. These findings suggest that online MBSR might help those at risk for Alzheimer's disease by boosting brain function and mental well-being.14678
Who Is on the Research Team?
Ruchika S Prakash, PhD
Principal Investigator
Ohio State University
Are You a Good Fit for This Trial?
This trial is for adults aged 50 or older who are experiencing mild cognitive decline and at risk for Alzheimer's disease. Participants must have access to the internet to use the programs. Specific inclusion and exclusion criteria details were not provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in an 8-week internet-based program, either iMBSR or iLifeEd, focusing on mindfulness or lifestyle education respectively.
Follow-up
Participants are monitored for changes in cognitive function, stress, quality of life, and AD biomarkers post-intervention.
What Are the Treatments Tested in This Trial?
Interventions
- Internet-based Lifestyle Education (iLifeEd)
- Internet-based Mindfulness-Based Stress Reduction (iMBSR)
Trial Overview
The study tests an 8-week online mindfulness program (iMBSR) against an online lifestyle education program (iLifeEd) in people with subjective cognitive decline. It aims to see if iMBSR can improve brain health compared to iLifeEd, using behavioral tests, brain scans, and real-time assessments.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will access mindfulness exercises using the ScarletCanvas platform and will complete them at their own pace throughout the intervention. The iMBSR protocol is developed to ensure that participants spend 2.5 hrs/week on each of the eight modules. The protocol will have a mix of didactics, experiential practices, social support, and community building. Experiential practices in iMBSR will include body scans, sitting meditations, and mindful movement.
Participants will access lifestyle education exercises using the ScarletCanvas platform and will complete them at-their own pace throughout the intervention. The iLifeEd protocol is developed to ensure that participants spend 2.5 hrs/week on each of the eight modules. The protocol will have a mix of didactics, experiential practices, social support, and community building. Experiential practices in iLifeEd will include stretching and toning exercises matched in duration to the practices of iMBSR.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor
National Institute on Aging (NIA)
Collaborator
Citations
The Effect of Mindfulness-Based Stress Reduction (MBSR) on ...
Mindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion ...
Mindfulness intervention for mild cognitive impairment led ...
Mindfulness-based interventions can enhance cognitive abilities among older adults, thereby effectively delaying cognitive decline.
Effectiveness of mindfulness‐based interventions on ...
This systematic review aimed to assess the effectiveness of MBIs on mental and cognitive outcomes including, anxiety, depression, attention, ...
Mindfulness-Based Stress Reduction With Older Adults ...
People living with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) experience less efficiency in performing complex everyday tasks ...
Mindfulness-based stress reduction for community-dwelling ...
Mindfulness-based stress reduction for community-dwelling older adults with subjective cognitive decline (SCD) and mild cognitive impairment ( ...
A Mindfulness-Based Lifestyle Intervention for Dementia ...
The secondary outcomes are cognitive function and lifestyle (physical activity, sleep, nutrition, alcohol and tobacco use, and mental and social ...
Meditation for subjective cognitive decline, mild ...
In this study, the impact of meditation was assessed on global cognitive performance, sleep quality, health status, and depression across the ...
Effects of Mindfulness Training and Exercise on Cognitive ...
The findings do not support the use of mindfulness training, exercise, or a combination of both for significantly improving cognitive function in older adults.
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