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MDD without CM but with elevated suicidality for Suicidal Thoughts

N/A

Recruiting

Led By Yogesh Dwivedi, PhD

Research Sponsored by University of Alabama at Birmingham

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18-60

Physically healthy

Must not have

You have been diagnosed with Bipolar Depression

You have been diagnosed with Psychosis

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 hours

Awards & highlights

Study Summary

This trial aims to investigate if childhood trauma and stress are linked to depression and suicidal risk. They will study how short-term and long-term stress affect miRNA levels, small genetic material found in the body

Who is the study for?

This trial is for adults aged 18-60 who are physically healthy. Participants can either have a diagnosis of Major Depressive Disorder (MDD) or no history of mental illness at all, and they must be able to understand and agree to the study's procedures.Check my eligibility

What is being tested?

The study is looking into how childhood trauma and stress might lead to depression or suicidal thoughts by testing levels of microRNA in the blood. The Trier Social Stress Test will be used as part of this research.See study design

What are the potential side effects?

Since this trial involves non-invasive procedures like blood tests, side effects may include temporary discomfort from needle insertion for blood draws.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

MicroRNA response to stress

Trial Design

6Treatment groups

Experimental Treatment

Group I: MDD without CM but with lower suicidalityExperimental Treatment1 Intervention

Major Depressive Disorder without childhood maltreatment but with lower suicidality scores.

Group II: MDD without CM but with elevated suicidalityExperimental Treatment1 Intervention

Major Depressive Disorder without childhood maltreatment, but with elevated suicidality scores.

Group III: MDD with elevated CM and suicidality scoresExperimental Treatment1 Intervention

Major Depressive Disorder with elevator childhood maltreatment and suicidality scores.

Group IV: MDD with CM history but lower suicidalityExperimental Treatment1 Intervention

Major Depressive disorder with childhood maltreatment history but lower suicidality scores.

Group V: Healthy controls without CM historyExperimental Treatment1 Intervention

Healthy controls without childhood maltreatment history.

Group VI: Healthy controls with CM historyExperimental Treatment1 Intervention

Healthy controls with childhood maltreatment history,

0 / 7Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor

1,591 Previous Clinical Trials

2,281,272 Total Patients Enrolled

2 Trials studying Suicidal Thoughts

266 Patients Enrolled for Suicidal Thoughts

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,242 Total Patients Enrolled

1 Trials studying Suicidal Thoughts

240 Patients Enrolled for Suicidal Thoughts

Yogesh Dwivedi, PhDPrincipal Investigator - University of Alabama at Birmingham

University of Alabama at Birmingham

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the eligibility criteria for individuals who can participate in this study?

"The trial seeks to enroll 450 individuals aged between 18 and 60 experiencing ideations of self-harm. Patients must satisfy the subsequent conditions: Aged between 18 and 60, in good physical health, capable and willing to offer informed consent, either diagnosed with Major Depressive Disorder or lacking any previous mental health issues."

Answered by AI

Is the enrollment for participants currently open in this clinical trial?

"According to information available on clinicaltrials.gov, this research endeavor is currently in the process of actively searching for suitable candidates. The trial was initially uploaded on February 26th, 2021 and underwent its most recent update on April 6th, 2023."

Answered by AI

What is the upper limit in terms of patient enrollment for this medical study?

"Indeed, the details on clinicaltrials.gov highlight that this investigation is presently enrolling subjects. The trial was initially listed on February 26th, 2021 and last revised on April 6th, 2023. It aims to recruit a total of 450 participants across two designated sites."

Answered by AI

Does the clinical trial include individuals who are older than 65 years?

"Patients within the age range of 18 to 60 are eligible for participation in this study. There are a total of 151 trials designated for individuals below 18 years old and 713 studies catering to those above 65."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

MicroRNA Correlates of Childhood Maltreatment and Suicidality

Yogesh Dwivedi, PhD 2021. "MicroRNA Correlates of Childhood Maltreatment and Suicidality". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04923685.