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Comprehensive Sequencing

Deep Sequencing Test for Intraocular Infections (OPTICS Trial)

N/A
Recruiting
Led By Thuy Doan, MD, PhD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presumed infectious anterior uveitis, intermediate uveitis, posterior uveitis, or panuveitis
Presumed post-operative endophthalmitis
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4-week after randomization
Awards & highlights

OPTICS Trial Summary

This trial is designed to compare the effectiveness of a new deep sequencing test for intraocular infections versus the current standard of care test. Patients who receive the new test will be compared to those who do not to see if there are improved outcomes.

Who is the study for?
This trial is for adults over 18 with suspected infectious uveitis or post-operative endophthalmitis, which are types of eye infections. It's not suitable for those who can't consent, don't have enough specimen for MDS testing, are under 18, or are pregnant.Check my eligibility
What is being tested?
The study compares the effectiveness of Metagenomic Deep Sequencing (MDS) to standard tests in improving treatment outcomes for eye infections. Participants will be randomly assigned to either receive MDS test results or not alongside regular care.See study design
What are the potential side effects?
Since this trial focuses on diagnostic methods rather than treatments, side effects aren't a primary concern. However, there may be general risks associated with collecting specimens required for MDS.

OPTICS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have an eye infection affecting the front, middle, back, or all parts of my eye.
Select...
I am suspected to have an eye infection after surgery.

OPTICS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4-week after randomization
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4-week after randomization for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Appropriate therapy
Clinical improvement
Secondary outcome measures
Infection status
Patient quality of life
Provider certainty of belief
+1 more

OPTICS Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: MDSExperimental Treatment1 Intervention
Patients enrolled in the trial and randomized to the MDS arm will undergo standard of care testing and MDS testing.
Group II: Standard of CareActive Control1 Intervention
Patients enrolled in the trial and randomized to the standard of care (SOC) arm will undergo standard of care testing.

Find a Location

Who is running the clinical trial?

University of California, Los AngelesOTHER
1,525 Previous Clinical Trials
10,279,734 Total Patients Enrolled
University of California, San FranciscoLead Sponsor
2,496 Previous Clinical Trials
11,933,789 Total Patients Enrolled
5 Trials studying Uveitis
411 Patients Enrolled for Uveitis
University of NebraskaOTHER
535 Previous Clinical Trials
1,143,806 Total Patients Enrolled
3 Trials studying Uveitis
36 Patients Enrolled for Uveitis

Media Library

MDS (Comprehensive Sequencing) Clinical Trial Eligibility Overview. Trial Name: NCT05286203 — N/A
Uveitis Research Study Groups: MDS, Standard of Care
Uveitis Clinical Trial 2023: MDS Highlights & Side Effects. Trial Name: NCT05286203 — N/A
MDS (Comprehensive Sequencing) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05286203 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there still openings to participate in this experiment?

"Affirmative. According to the clinicaltrials.gov database, this experiment is currently seeking participants and was originally posted on June 6th 2022 with updates occuring as recently as July 5th 2022. The study requires 100 people from a single medical facility for enrolment purposes."

Answered by AI

What does this clinical experiment hope to demonstrate?

"This medical trial, evaluated over 4 weeks after randomisation, aims to evaluate clinical improvement. Secondary objectives include measuring infection status with latent class analysis and traditional tests; calculating provider quality of care through the World Health Organization Quality of Life Abbreviated Questionnaire; as well as capturing a provider's certainty on whether or not a patient has an infection (on a continuous scale from 0-100%)."

Answered by AI

What is the current capacity to enroll participants for this medical experiment?

"Affirmative, the information hosted on clinicaltrials.gov verifies that this medical trial is currently recruiting. Its first posting was June 6th 2022 and its most recent edit occurred July 5th 2022; 100 patients are needed from a single site."

Answered by AI

Who else is applying?

What site did they apply to?
University of California San Francisco (UCSF)
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1

What questions have other patients asked about this trial?

What is involved to be a part of this trial?
PatientReceived no prior treatments

Why did patients apply to this trial?

I have recurrent uveitis and would love a cure!
PatientReceived no prior treatments
~60 spots leftby Dec 2026