← Back to Search

Water-Based Exercise + Cognitive Training for Mild Cognitive Impairment (WATER-Vet Trial)

Phase 4
Recruiting
Led By Jennifer Kaci Fairchild, PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of single or multi-domain amnestic MCI using criteria per National Institute on Aging/Alzheimer's Association Guidelines
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 months
Awards & highlights

WATER-Vet Trial Summary

This trial will study whether adding an exercise program to a cognitive training program can help improve memory performance in Veterans with aMCI.

Who is the study for?
Veterans aged 50-90 with mild cognitive impairment (aMCI) who can undergo neuropsychological testing and are approved for water-based exercise by their primary care provider. They need an informant for clinical assessments and must commit to a 14-month trial period. Excluded are those with severe psychiatric disorders, dementia, unstable chronic illnesses, or conditions affecting central nervous system function.Check my eligibility
What is being tested?
The study is examining the effectiveness of combining aquatic exercises with cognitive training to improve memory in veterans with aMCI. Participants will first engage in water-based physical activities followed by a program designed to enhance cognitive functions over an eight-month treatment phase.See study design
What are the potential side effects?
While specific side effects are not detailed for this type of intervention, general risks may include muscle soreness or injury from physical activity and potential stress or frustration associated with cognitive training exercises.

WATER-Vet Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with mild cognitive impairment as per national guidelines.

WATER-Vet Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cognitive Function Composite Score (ADAS-Cog-Exe)
Secondary outcome measures
Peak VO2

WATER-Vet Trial Design

2Treatment groups
Experimental Treatment
Group I: WATER+CTExperimental Treatment1 Intervention
This is an 8 month long two phase intervention. The first phase consists of 6 months of thrice weekly pool based physical activity occurring at the Palo Alto VA Health Care System. After completion of the 6 month long water based physical activity, participants transition to a ten session cognitive training program at the Palo Alto VA. The cognitive training classes are approximately two hours in length and will be spread over ten sessions across 4 weeks.
Group II: Usual CareExperimental Treatment1 Intervention
Usual Care condition involves receipt of educational materials about brain health and healthy lifestyles as well as regular contact with study staff.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Usual Care
1990
Completed Phase 4
~7700

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,611 Previous Clinical Trials
3,305,154 Total Patients Enrolled
Jennifer Kaci Fairchild, PhDPrincipal InvestigatorVA Palo Alto Health Care System, Palo Alto, CA
2 Previous Clinical Trials
151 Total Patients Enrolled

Media Library

WATER+CT Clinical Trial Eligibility Overview. Trial Name: NCT04296565 — Phase 4
Mild Cognitive Impairment Research Study Groups: Usual Care, WATER+CT
Mild Cognitive Impairment Clinical Trial 2023: WATER+CT Highlights & Side Effects. Trial Name: NCT04296565 — Phase 4
WATER+CT 2023 Treatment Timeline for Medical Study. Trial Name: NCT04296565 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this experiment accept individuals under the age of sixty?

"This trial is enrolling participants aged 50 to 90 years."

Answered by AI

What potential hazards come with the implementation of WATER+CT?

"Our team at Power awarded WATER+CT a safety rating of 3, due to it being in the Phase 4 trial stage and thus having governmental authorization."

Answered by AI

Is recruitment for the study still ongoing?

"Affirmative. According to clinicaltrials.gov, this clinical trial is presently accepting applications with the initial posting date being on March 1st 2022 and most recent update occurring on January 19th 2022. The research team seeks 130 participants from a single site for their trail."

Answered by AI

What is the capacity of this scientific investigation?

"Affirmative. According to the information hosted on clinicaltrials.gov, this trial is actively searching for qualified participants; it was initialy advertised on March 1st 2022 and last updated on January 19th of the same year. The researchers are trying to recruit a total of 130 patients from one location."

Answered by AI

Am I eligible to join this investigative project?

"To qualify for this trial, candidates must satisfy the following requirements: be at least 50 and below 90 years old; have experienced cognitive decline; be a veteran of any racial or ethnic background; possess an informant who can complete the Clinical Dementia Rating Scale (CDR); agree to participate in the 14-month clinical trial which includes 8 months of treatment and 6 months of no contact follow up. Furthermore, potential participants should not suffer from musculoskeletal illness such as osteoporosis, degenerative disc/joint disease, arthritis or obesity."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Water-based Activity to Enhance Recall in Veterans
2022. "Water-based Activity to Enhance Recall in Veterans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04296565.
~38 spots leftby Mar 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top