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Radiation + Chemotherapy for Small Cell Lung Cancer
Study Summary
This trial is testing different radiation therapy regimens to see which is more effective in treating patients with limited-stage small cell lung cancer when given together with chemotherapy.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You must have a certain level of white blood cells called granulocytes in your blood.My kidney function, measured by creatinine levels or clearance, is within the required range.My cancer is in one side of my chest and has spread to nearby lymph nodes.My cancer is confined to one side of my chest and has spread only to nearby lymph nodes.I have had only one round of chemotherapy that included carboplatin or cisplatin and etoposide.I have not had surgery to completely remove my cancer.My lung cancer diagnosis was confirmed through lab tests.I have a tumor that can be measured by scans.I do not have fluid in my lungs or, if I do, it has been tested and is not cancerous.I haven't had chemo or radiation for small cell lung cancer, except as noted before.I am 18 years old or older.My kidney function, measured by creatinine levels or clearance, is within the required range.My cancer has spread to lymph nodes above my collarbone or on the opposite side of my chest.Your AST (SGOT) level should be no more than 2 times the upper limit of normal.You have a certain type of white blood cells called granulocytes, and you need to have at least 1,500 of them in a tiny drop of blood.My lung cancer diagnosis was confirmed through lab tests.Your AST (SGOT) level is not more than 2 times the upper limit of normal.Your platelet count is at least 100,000 per microliter.Your blood platelet count is at least 100,000 per microliter.I have not had radiation therapy to my chest area.I do not have cancer cells in my chest or heart fluid.Your total bilirubin level is less than 1.5 times the upper limit of normal.I can care for myself and am up and about more than 50% of my waking hours.Your total bilirubin level is not more than 1.5 times the upper limit of normal.I have a tumor that can be measured by scans.
- Group 1: Arm B - High Dose Radiotherapy + Chemotherapy
- Group 2: Arm A - Standard Radiotherapy + Chemotherapy
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many different places in Canada are running this trial?
"Ochsner Medical Center Jefferson in New Orleans, Louisiana, Memorial Sloan Kettering Nassau in Uniondale, New york, and Cooper Hospital University Medical Center in Camden, New jersey, are all participating in this clinical trial, which is also running at 100 other hospitals."
What are some risks associated with High Radiation Dose Therapy?
"High Radiation Dose Therapy received a 3 because there is both evidence of efficacy and multiple rounds of data affirming its safety."
How does High Radiation Dose Therapy compare to other treatments?
"There are presently 1323 ongoing clinical trials for High Radiation Dose Therapy, with the majority of these being in Phase 3. The 427 trials for High Radiation Dose Therapy are primarily located in Shanghai, but there are 70884 locations running clinical trials for High Radiation Dose Therapy globally."
How is High Radiation Dose Therapy most often used?
"While most commonly used to treat advanced non small cell lung cancer, High Radiation Dose Therapy has also shown efficacy against other conditions such as recurrent, advance directives, and advanced cervical cancer."
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