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Radiation Therapy
Radiation Therapy for Sarcoma
Phase 2
Waitlist Available
Led By Matthew Krasin, MD
Research Sponsored by St. Jude Children's Research Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Musculoskeletal tumor involving the primary site of origin requiring definitive, pre-operative or post-operative irradiation to that primary site.
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up time to local failure (local control) over 10 years follow-up after completion of therapy
Awards & highlights
Study Summary
This trial is testing new ways to deliver radiation therapy to children with bone and soft tissue tumors, with the goal of improving local control of the tumor while minimizing side effects.
Who is the study for?
This trial is for individuals up to 25 years old with musculoskeletal tumors such as sarcoma, who haven't had prior radiation at the tumor site (except for emergency treatment). It includes those with or without metastatic disease and allows patients undergoing various treatments like surgery or chemotherapy. Pregnant women can't participate, and those with recurrent tumors are eligible if the area hasn't been irradiated before.Check my eligibility
What is being tested?
The study tests image-guided radiotherapy (IGRT) in treating pediatric bone and soft tissue tumors. IGRT uses advanced imaging techniques like CT, MRI, and PET scans to target radiation precisely at the tumor while sparing healthy tissues around it.See study design
What are the potential side effects?
While this trial aims to minimize side effects by targeting radiation more accurately, potential risks may include skin irritation, fatigue, localized pain, possible damage to nearby organs/tissues depending on the tumor's location.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My bone or muscle cancer needs radiation before or after surgery.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ time to local failure (local control) over 10 years follow-up after completion of therapy
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time to local failure (local control) over 10 years follow-up after completion of therapy
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Cumulative incidence of local control, pattern of failure (local or metastatic)
Secondary outcome measures
Changes in growth rate and length of bone, bone density, development of muscle (muscle function, e.g. range of motion), occurrence of organ specific (e.g. lung, skin) CTC measured toxicities.
Muscle function over time, PET, DCE-MR, T2* MR quantitative parameters.
Trial Design
1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention
Eligible patients will be accessioned at the time of irradiation and undergo a pre-radiotherapy evaluation, treatment planning, image-guided radiotherapy delivery and intra-and post-irradiation evaluations.
Find a Location
Who is running the clinical trial?
St. Jude Children's Research HospitalLead Sponsor
428 Previous Clinical Trials
5,306,411 Total Patients Enrolled
Lance Armstrong FoundationOTHER
9 Previous Clinical Trials
849 Total Patients Enrolled
Matthew Krasin, MDPrincipal InvestigatorSt. Jude Children's Research Hospital
1 Previous Clinical Trials
31 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 25 years old or younger and enrolling for the first time.I haven't had radiation at the cancer's original site, except for a short emergency treatment.My cancer is either localized or has spread to other parts of my body.I am eligible for radiation therapy, possibly with surgery or chemotherapy, for my current cancer.My bone or muscle cancer needs radiation before or after surgery.
Research Study Groups:
This trial has the following groups:- Group 1: Treatment
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What are the side effects of this particular treatment?
"This is a Phase 2 trial, which means that while there is some data supporting safety, there is none yet available to confirm efficacy. Therefore, the Power team gives this treatment a score of 2 in terms of safety."
Answered by AI
Are there any more openings for participants in this trial?
"This specific trial is not presently looking for patients, as per the information available on clinicaltrials.gov. This page was last edited on 4/4/2022, and it shows that the trial was initially posted on 1/10/2003. There are 489 other trials actively recruiting patients right now."
Answered by AI
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