← Back to Search

Radiation Therapy

Targeted Radiation Therapy for Brain Cancer (CogRT Trial)

Q: Are participants of this research being recruited from all age groups, including those over 75?

The requisites for entering this trial dictate that the youngest permitted participant is 1 Year old, while the oldest can be no older than 26.

Q: Are any slots still available to volunteer for this experiment?

As per the information found on clinicaltrials.gov, this trial is not presently recruiting participants. This study was initially posted on January 1st 2023 and has seen its last update as of December 13th 2022. Unfortunately, it does not appear to be searching for candidates currently; nevertheless, there are 885 other trials that are actively seeking volunteers at this time.

Q: Is it possible for me to become a participant in this medical study?

This medical research endeavour is looking for 338 participants aged one year up to 26 years old who have neoplasms in the brain or areas adjacent to it such as the nasopharynx, paranasal sinuses and orbit. STRATUM A eligibility criteria must be met by <a href="https://www.withpower.com/clinical-trials/all">all</a> subjects; they cannot have finished radiation therapy yet, and this treatment will form part of their involvement.

N/A

Recruiting

Research Sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to 5 years

Awards & highlights

CogRT Trial Summary

This trial tests if better radiation planning can reduce brain impairment for kids with brain tumors. It will compare the effects of different radiation treatments on the brain.

Who is the study for?

This trial is for children and young adults aged 1 to <26 with new brain or head and neck tumors needing radiation therapy. It includes those who finished radiation at least two years ago without recurrence, and healthy kids for comparison.Check my eligibility

What is being tested?

The study tests if targeting radiation more precisely to protect brain areas important for thinking can reduce learning impairments. Participants undergo neurocognitive testing and MRI scans to assess the impact of different radiation plans.See study design

What are the potential side effects?

While not a treatment, this trial involves risks from additional MRIs like discomfort or reactions in claustrophobic patients, plus potential distress from extra neurocognitive testing.

CogRT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of plans that meet substructure-informed planning constraints

Secondary outcome measures

Cumulative incidence of local and distant tumor recurrence

Fractional anisotropy values

characterize longitudinal CVLT scores in survivors of pediatric brain tumor who are ≥ 2 years post radiation

+3 more

CogRT Trial Design

3Treatment groups

Experimental Treatment

Group I: Stratum C (healthy controls matched to Stratum A)Experimental Treatment2 Interventions

Healthy patients who are matched to Stratum A patients

Group II: Stratum B (patients ≥ 2 years after standard radiation therapy)Experimental Treatment2 Interventions

Patients who completed radiation therapy under standard planning procedures ≥ 2 years ago.

Group III: Stratum A (new diagnosis, substructure informed radiation therapy)Experimental Treatment3 Interventions

Patients will undergo radiation therapy which has been planned according to dose constraints to specific brain substructures.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

MRI

2009

Completed Phase 2

~1370

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsLead Sponsor

557 Previous Clinical Trials

32,562 Total Patients Enrolled

Media Library

Radiation Therapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05658731 — N/A

Brain Tumor Research Study Groups: Stratum A (new diagnosis, substructure informed radiation therapy), Stratum B (patients ≥ 2 years after standard radiation therapy), Stratum C (healthy controls matched to Stratum A)

Brain Tumor Clinical Trial 2023: Radiation Therapy Highlights & Side Effects. Trial Name: NCT05658731 — N/A

Radiation Therapy (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05658731 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants of this research being recruited from all age groups, including those over 75?

"The requisites for entering this trial dictate that the youngest permitted participant is 1 Year old, while the oldest can be no older than 26."

Answered by AI

Are any slots still available to volunteer for this experiment?

"As per the information found on clinicaltrials.gov, this trial is not presently recruiting participants. This study was initially posted on January 1st 2023 and has seen its last update as of December 13th 2022. Unfortunately, it does not appear to be searching for candidates currently; nevertheless, there are 885 other trials that are actively seeking volunteers at this time."

Answered by AI

Is it possible for me to become a participant in this medical study?

"This medical research endeavour is looking for 338 participants aged one year up to 26 years old who have neoplasms in the brain or areas adjacent to it such as the nasopharynx, paranasal sinuses and orbit. STRATUM A eligibility criteria must be met by all subjects; they cannot have finished radiation therapy yet, and this treatment will form part of their involvement."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

2023. "Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05658731.

All > Radiotherapy