← Back to Search

Methionine Imaging for Cancer Detection

Phase 2
Recruiting
Led By Barry L Shulkin, MD
Research Sponsored by St. Jude Children's Research Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up end of study (maximum of 3 years post methionine infusion and pet scan)
Awards & highlights

Study Summary

This trial is testing the usefulness of imaging with radiolabeled methionine to find tumors in children and young adults.

Who is the study for?
This trial is for children and young adults with various types of cancer, including brain tumors and sarcomas. Participants can be any age or gender, must not be breastfeeding if they are of childbearing age, have consented to the study, and are under the care of St. Jude physicians.Check my eligibility
What is being tested?
The trial is testing a diagnostic imaging technique using C-11 methionine (MET) with PET/CT scans to evaluate tumor presence and response to therapy in patients with malignant solid neoplasms, focusing on CNS tumors and sarcomas.See study design
What are the potential side effects?
Since this trial involves diagnostic imaging rather than medication or treatment intervention, side effects may include exposure to radiation. However, specific side effects related to MET PET/CT scans are not detailed.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~end of study (maximum of 3 years post methionine infusion and pet scan)
This trial's timeline: 3 weeks for screening, Varies for treatment, and end of study (maximum of 3 years post methionine infusion and pet scan) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Success rate of methionine (MET) for visualizing tumors
Secondary outcome measures
Association of methionine uptake with tumor grade
Bio-distribution of MET in organs

Trial Design

1Treatment groups
Experimental Treatment
Group I: ParticipantsExperimental Treatment1 Intervention
Participants who meet the eligibility criteria in the study will receive methionine.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methionine
2019
Completed Phase 2
~10

Find a Location

Who is running the clinical trial?

St. Jude Children's Research HospitalLead Sponsor
427 Previous Clinical Trials
5,305,927 Total Patients Enrolled
Barry L Shulkin, MDPrincipal InvestigatorSt. Jude Children's Research Hospital

Media Library

Methionine Clinical Trial Eligibility Overview. Trial Name: NCT00840047 — Phase 2
Solid Tumors Research Study Groups: Participants
Solid Tumors Clinical Trial 2023: Methionine Highlights & Side Effects. Trial Name: NCT00840047 — Phase 2
Methionine 2023 Treatment Timeline for Medical Study. Trial Name: NCT00840047 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Methionine earned regulatory approval from the FDA?

"While lacking efficacy data, the existing safety information has led to our team's assessment of Methionine with an intermediate level risk rating of 2."

Answered by AI

Is this trial recruiting new participants at the moment?

"Affirmative, the information on clinicaltrials.gov states that recruitment for this trial is presently in progress. The study was first submitted to the website on July 20th 2009 and updated most recently on July 5th 2022. 650 participants are being sought at 1 individual site."

Answered by AI

Has this trial been conducted previously, or is it a novel endeavor?

"Since 2007, Methionine has been subject to scientific scrutiny. The first study sponsored by Baxter Healthcare Corporation was completed in 2007 and featured 4640 patients; this trial led to the Phase 4 approval of Methionine. Currently, 5 ongoing studies are being conducted across 3 cities and nations."

Answered by AI

How many participants have been enrolled in this investigation?

"Affirmative. Clinicaltrials.gov's records show that this clinical trial is actively enrolling patients since its publication in July 20th 2009 and most recent update on June 5th 2022. The research project necessitates 650 participants from a single medical centre."

Answered by AI

Who else is applying?

What state do they live in?
Indiana
Arizona
Other
New York
What portion of applicants met pre-screening criteria?
Met criteria
~117 spots leftby Jul 2027