Your session is about to expire
← Back to Search
Radiation Therapy
Stereotactic Body Radiation Therapy for Cancer
N/A
Recruiting
Led By Yi-Jen Chen
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 year
Awards & highlights
Study Summary
This trial tests a new radiation therapy to target and treat tumors with fewer doses and less damage to healthy tissue.
Who is the study for?
This trial is for adults over 18 with polymetastatic cancer, meaning they have more than five tumor lesions and limited treatment options. They should be in relatively good health (Karnofsky performance status > 60), not currently on systemic therapy, and expected to live at least three months. Pregnant or breastfeeding women are excluded, as well as those unable to undergo CT scans or comply with study procedures.Check my eligibility
What is being tested?
The trial tests spatiotemporal stereotactic body radiation therapy (ST-SBRT) for patients with solid tumors that have spread widely. ST-SBRT aims to precisely target the core of tumors while minimizing damage to surrounding tissues, potentially offering a safer and quicker treatment option.See study design
What are the potential side effects?
While specific side effects aren't listed here, SBRT can generally cause fatigue, skin reactions at the treated site, mild swelling or pain around the area of radiation. Less commonly it might affect nearby organs depending on where the treatment is targeted.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 1 year
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 year
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Effectiveness of ST-SBRT
Incidence of adverse events
Secondary outcome measures
Change in quality of life
Change in volume (per lesion)
Clinical response per fraction (per lesion)
+5 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Treatment (ST-SBRT)Experimental Treatment3 Interventions
Patients undergo ST-SBRT on study. Patients also undergo collection of blood samples at screening and on study and undergo CT at screening, on study, and during follow up.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Computed Tomography
2017
Completed Phase 2
~2720
Biospecimen Collection
2004
Completed Phase 2
~1700
Stereotactic Body Radiation Therapy
2012
Completed Phase 2
~780
Find a Location
Who is running the clinical trial?
National Cancer Institute (NCI)NIH
13,669 Previous Clinical Trials
40,926,381 Total Patients Enrolled
City of Hope Medical CenterLead Sponsor
567 Previous Clinical Trials
1,922,640 Total Patients Enrolled
Yi-Jen ChenPrincipal InvestigatorCity of Hope Medical Center
1 Previous Clinical Trials
300 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 18 years old or older.I have serious health issues that prevent me from receiving radiotherapy.I have had radiotherapy that meets specific safety guidelines.My brain metastases have been treated and are stable as shown by a recent MRI.I have had treatment for cancer that spread to my spine.I am currently on medication for my condition.I have been deemed ineligible for SBRT by a radiation oncologist.My pre-screening shows I can safely receive the treatment without exceeding safe dose limits.My cancer has spread widely with more than 5 large tumors and standard treatments are not working.I haven't taken any systemic therapy for at least a month.I can care for myself but may not be able to do active work.I am not pregnant or breastfeeding and have a negative pregnancy test.
Research Study Groups:
This trial has the following groups:- Group 1: Treatment (ST-SBRT)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is the trial currently enrolling new participants?
"Clinicaltrials.gov indicates that this study, which premiered on June 15th 2023 and was last updated February 15th 2023, is not currently seeking candidates. However, there are 86 other trials convening participants presently."
Answered by AI
What are the fundamental goals of this examination?
"This trial's primary objective is to ascertain the effectiveness of ST-SBRT within 3 months post last fraction. Secondary criteria include evaluating the number and adaptation of treatment fractions, as well as determining if there are any abscopal effects detected by CT scan 4 weeks after a given ST-SBRT session. All measurements will be summarized statistically."
Answered by AI
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger