MitoQ for Aging

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
University of Colorado Boulder, Boulder, CO
Aging
MitoQ - DietarySupplement
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans

See full description

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Aging

Study Objectives

This trial is evaluating whether MitoQ will improve 1 primary outcome, 2 secondary outcomes, and 4 other outcomes in patients with Aging. Measurement will happen over the course of 3 months.

3 months
Change from baseline in aortic stiffness at 3 months
Change from baseline in carotid artery stiffness at 3 months
Change from baseline in circulating marker of oxidative stress at 3 months
Change from baseline in endothelial cell markers of oxidative stress and mitochondrial health from baseline at 3 months
Change from baseline in endothelial function at 3 months
Change from baseline in serum exposure-induced endothelial cell reactive oxygen species production at 3 months
Change from baseline in suppression of endothelial function by mitochondrial oxidative stress at 3 months

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Other trials for Aging

Trial Design

2 Treatment Groups

MitoQ, 20 mg/day
1 of 2
Placebo
1 of 2
Experimental Treatment
Non-Treatment Group

This trial requires 112 total participants across 2 different treatment groups

This trial involves 2 different treatments. MitoQ is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

MitoQ, 20 mg/day
DietarySupplement
Each MitoQ capsule contains 20 mg of mitoquinol mesylate. Dosage: 20 mg orally per day for 3 months.
Placebo
DietarySupplement
Matched placebo capsules.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MitoQ
2006
Completed Phase 2
~200

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 3 months for reporting.

Who is running the study

Principal Investigator
D. S.
Douglas Seals, PI
University of Colorado, Boulder

Closest Location

University of Colorado Boulder - Boulder, CO

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Willing to accept random assignment to condition
Body mass index <40 kg/m2
Age 60 years and over
Ability to provide informed consent
Weight stable in the prior 3 months (<2 kg weight change) and willing to remain weight stable throughout the study
Free from alcohol dependence or abuse
Mini-mental stage examination score ≥21

Patient Q&A Section

What are the signs of aging?

"Aging can affect the senses, and signs can sometimes be mistaken for changes due to aging. The ability to smell a scent decreases with aging, but may still be noticeable after adjusting for other olfactory function abilities. Visual acuity may also decrease with aging, but may be noticed with appropriate correction. Hearing is preserved until 70 years of age, but can be affected in later adulthood. Men and women become affected to a similar pattern. All of these changes can lead to a variety of mistaken signs of aging, including visual problems on a computer screen that may not be noticed by a doctor, changes in appearance that are perceived as normal aging (such as sunken cheeks and double chin), and changes in body image as people become obese or thin." - Anonymous Online Contributor

Unverified Answer

What causes aging?

"Although the aging process and its various components have been found to be multifactorial and can be affected by many environmental factors, it is still unknown what causes its acceleration and how all of these factors interact with each other. Aging is a complex process in which many of the same factors that influence longevity may also contribute to aging." - Anonymous Online Contributor

Unverified Answer

How many people get aging a year in the United States?

"Approximately 4.9 million people per year in the United States are diagnosed as having some form of age-related macular degeneration. This makes up 12.8% of American people." - Anonymous Online Contributor

Unverified Answer

What is aging?

"Aging is an adaptive process, allowing organisms to control cell growth and reproduction. This process is not only the result of the accumulation of senescence, but also the natural result of the gradual decay caused by many cellular functions, including programmed cell death. While most tissues are not thought to be very much at-risk for senescence, many of the tissues that make up the skin are prone to such aging effects. As an example, skin loses many tissue cells after wounding, with a loss exceeding 1/3 of old tissue cells every 2-3 weeks, and then gradually goes back to initial number, though never in exactly a straight line." - Anonymous Online Contributor

Unverified Answer

What are common treatments for aging?

"There are several common treatments that have been shown to improve people's quality of life. A common treatment and medication in general is the use of vitamins (D and C) and dietary supplements. There is evidence that some herbal medicines have efficacy over the-counter medications. If needed, psychotherapy is a common and effective form of treatment for mental health. Physical therapy is another commonly used treatment for all ages. There is also evidence that non-pharmaceutical strategies are effective for addressing many physical health issues, even for individuals who have a chronic condition or persistent diseases." - Anonymous Online Contributor

Unverified Answer

Can aging be cured?

"The evidence suggests that there is no cure for aging. It has been argued that there is a strong evolutionary rationale for aging and it may even have been selected for, so it could not be cured." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of mitoq?

"In a recent study, findings of the present study showed that side effects in the two randomized trials were in line with those obtained in studies examining mitoq's efficacy. This suggests that there were only minor differences between treatment groups (e.g., in relation to frequency of side effects). Side effects were not associated with the treatment group, which suggests that they were not related to the formulation. The severity of side effects depended on the study design and dosage of mitoq and its ingredients. The presence of side effects should be taken into account during drug planning and during the course of treatment." - Anonymous Online Contributor

Unverified Answer

Is mitoq safe for people?

"Using a large community-based cohort study of patients over 70 years, no association between Mitoq use and cognitive impairment was identified, suggesting that its use is safe for the average aged patient." - Anonymous Online Contributor

Unverified Answer

What is mitoq?

"MitigloQ® is efficacious in improving fatigue and QoL for patients with moderate to severe rheumatoid arthritis. The use of this product offers patients an improved quality of life that may not be previously achievable. Findings from a recent study provide additional support for the use of mitoq in patients with moderate to severe RA." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of aging?

"We used a non-experimental method to quantify the contribution of genes and mutation rates to biological aging in budding yeast. The combined data strongly suggest that mutation rates are the primary driver of biological aging in yeast, not the underlying genomic context. Our analysis provides a quantitative basis for investigating the role of mutation rate in aging more broadly and for identifying biological mechanisms that may regulate aging." - Anonymous Online Contributor

Unverified Answer

What is the latest research for aging?

"When looking for the new research on aging, [research agendas from the most prominent [scientific journals in the field of geriatrics, psychiatry, and medicine.]<ref name="doi:10." - Anonymous Online Contributor

Unverified Answer

What does mitoq usually treat?

"Although most MitoQ users received prescription medication, the patient population can be broadly divided into individuals with some conditions for which the FDA has approved MitoQ for the relief of symptoms without a specific indication." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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