Preventive Surgery for Ovarian Cancer
Trial Summary
What is the purpose of this trial?
This phase II trial studies how well surgery works in preventing ovarian cancer in patients with genetic mutations at risk of ovarian cancer. Risk reducing salpingo oophorectomy (RRSO) is surgery to remove the fallopian tubes and ovaries at the same time. Interval salpingectomy with delayed oophorectomy (ISDO) is surgery to remove the fallopian tubes. It is not known whether ISDO works better than RRSO at lowering risk of ovarian cancer and improving the sexual function and psychosocial well-being in patients with genetic mutation.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently being treated with Tamoxifen or Aromatase Inhibitors.
What data supports the effectiveness of the treatment Surgery for Preventive Surgery for Ovarian Cancer?
Is preventive surgery for ovarian cancer generally safe for humans?
How does preventive surgery for ovarian cancer differ from other treatments?
Preventive surgery for ovarian cancer, specifically prophylactic oophorectomy or salpingo-oophorectomy, is unique because it involves the removal of the ovaries and/or fallopian tubes to significantly reduce the risk of developing ovarian cancer, especially in women with genetic risk factors like BRCA mutations. Unlike other treatments that focus on managing the disease after it occurs, this surgery is a preventive measure aimed at high-risk individuals to prevent cancer from developing in the first place.1112131415
Research Team
Roni N Wilke, MD
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for premenopausal women with certain genetic mutations linked to a high risk of ovarian cancer. Participants must be willing to undergo surgery and follow-up care, not currently pregnant or within 3 months post-partum, have at least one fallopian tube and ovary, and cannot be on specific cancer medications.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients undergo either ISDO or RRSO surgery to prevent ovarian cancer
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Surgery
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Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator