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Why We Started Power

We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

Bask
Bask GillCEO at Power
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      Why We Started Power

      We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

      Bask
      Bask GillCEO at Power
      Learn More About Trials
      How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?

      31 Acne Trials Near You

      Power is an online platform that helps thousands of Acne patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

      Learn More About Power
      No Placebo
      Highly Paid
      Stay on Current Meds
      Pivotal Trials (Near Approval)
      Breakthrough Medication

      Spironolactone vs Doxycycline for Acne

      Columbus, Ohio
      This trial compares two treatments for women with moderate to severe acne. One treatment helps balance hormones to reduce skin oiliness, while the other kills bacteria and reduces inflammation. The goal is to see which treatment is more effective and potentially reduce the need for long-term antibiotic use.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 4
      Age:16 - 40
      Sex:Female

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Heart Disease, Renal Disease, Others
      Must Not Be Taking:Ace Inhibitors, Arbs, Nsaids, Digoxin

      350 Participants Needed

      Tibulizumab for Hidradenitis Suppurativa

      Columbus, Ohio
      The study is a Phase 2, multi-center, randomized, double-blind, placebo-controlled study to evaluate the effects of tibulizumab over 16 weeks (Period 1) in adults with hidradenitis suppurativa, followed by a 16-week open-label extension period in which all participants will receive tibulizumab (Period 2)

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Tuberculosis, Immune Deficiency, Infections, Others

      180 Participants Needed

      Povorcitinib for Hidradenitis Suppurativa

      Bexley, Ohio
      This trial is testing a medication called Povorcitinib to see if it helps people with moderate to severe Hidradenitis Suppurativa (HS). HS is a painful skin condition that often doesn't respond well to regular treatments. Povorcitinib aims to reduce inflammation and other symptoms by calming the immune system.
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Cancer, Infections, Others
      Must Not Be Taking:Antibiotics, Antiseptics

      608 Participants Needed

      Bimekizumab for Hidradenitis Suppurativa

      Columbus, Ohio
      This trial is testing the safety of bimekizumab, a medication for people with moderate to severe hidradenitis suppurativa (HS). Bimekizumab aims to reduce inflammation and alleviate symptoms by targeting certain proteins in the body.
      No Placebo Group
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Breastfeeding, Serious Infections, Others
      Must Be Taking:Bimekizumab

      658 Participants Needed

      Povorcitinib for Hidradenitis Suppurativa

      Bexley, Ohio
      This trial is testing a medication called Povorcitinib to see if it helps people with moderate to severe Hidradenitis Suppurativa (HS). HS is a skin condition that causes painful lumps and sores. The medication aims to reduce inflammation and improve symptoms over several months, with additional follow-up.
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Cardiovascular Diseases, Infections, Others
      Must Not Be Taking:JAK Inhibitors

      619 Participants Needed

      Povorcitinib for Hidradenitis Suppurativa

      Bexley, Ohio
      The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 \[NCT05620823\] or INCB 54707-302 \[NCT05620836\]).
      No Placebo Group
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Breastfeeding, Others

      960 Participants Needed

      Remibrutinib for Hidradenitis Suppurativa

      Columbus, Ohio
      The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) Dose A and Dose B compared to placebo in participants with moderate to severe hidradenitis suppurativa (HS).
      Prior Safety Data
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Hepatic Disease, Cardiovascular, Neurological, Others
      Must Not Be Taking:Antiplatelets, Anticoagulants

      555 Participants Needed

      ATR04-484 for Acneiform Rash

      Gahanna, Ohio
      The goal of this randomized clinical trial is to learn if topical treatment with ATR04-484 can treat skin rash in patients undergoing EGFR inhibitor (EGFRi) therapy. The primary goal of the study is to determine safety and tolerability of ATR04-484, and the secondary goal of the study is to assess efficacy signals of ATR04-484. Researchers will compare treatment of ATR04-484 to its vehicle. Participants will: * Apply ATR04-484 or vehicle daily for 28 days * Visit the clinic periodically for evaluation and sample collection

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 1, 2

      Key Eligibility Criteria

      Disqualifiers:Significant Skin Disease, Others
      Must Not Be Taking:Topical Corticosteroids, Systemic Antibiotics

      32 Participants Needed

      AVTX-009 for Hidradenitis Suppurativa

      Dublin, Ohio
      The main purpose of this study is to evaluate the efficacy and safety of AVTX-009 compared with placebo in patients with moderate to severe Hidradenitis Suppurativa (HS).

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Active Skin Condition, Chronic Infection, Uncontrolled Disease, Others

      250 Participants Needed

      Camoteskimab for Eczema

      Cleveland, Ohio
      This is a Phase 2a, multicenter, randomized, double-blind, placebo-controlled study with an open-label extension to evaluate the efficacy and safety of camoteskimab in adults with moderate to severe AD.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Other Skin Diseases, Severe Comorbidities, Active Infections, Others
      Must Not Be Taking:Biologics, JAK Inhibitors

      62 Participants Needed

      mRNA Vaccine for Acne

      Allen Park, Michigan
      The purpose of the trial is to evaluate the safety, efficacy and immunogenicity of up to 3 intramuscular injections of the Acne mRNA vaccine candidate at up to three dose levels in adult participants aged 18 to 45 years with moderate to severe acne. This trial will consist of a Core Study followed by an optional Long-Term Extension (LTE). The Core Study will consist of a Sentinel Cohort A paired with a Main Cohort, evaluating the safety and efficacy of the 2-administration regimen and a Sentinel Cohort B, evaluating the safety of the 3- administration regimen. The Sentinel Cohorts will assess the safety of the dose levels and regimens in a stepwise manner. If the participants consent to the LTE, they will be followed up for an additional 30 months after the last planned visit in the Core Study, to assess the long-term effects of the vaccine.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 1, 2
      Age:18 - 45

      Key Eligibility Criteria

      Disqualifiers:Immunodeficiency, Active Nodulocystic Acne, Others
      Must Not Be Taking:Immunosuppressants, Corticosteroids, Others

      260 Participants Needed

      Investigational Treatments for Hidradenitis Suppurativa

      Indianapolis, Indiana
      The main purpose of this study is to assess preliminary efficacy and safety of CFZ533, LYS006, MAS825 , LOU064 and VAY736 in patients with moderate to severe hidradenitis suppurativa and to determine if CFZ533, LYS006, MAS825, LOU064 and VAY736 have an adequate clinical profile for further clinical development.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 2
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Lactation, Others
      Must Not Be Taking:Investigational Drugs

      248 Participants Needed

      Radiofrequency for Acne

      Grosse Pointe, Michigan
      Evaluation of the safety and efficacy of fractional radiofrequency for the treatment of moderate to severe acne vulgaris.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased
      Age:18 - 25

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Cancer, Cardiac Disorders, Others
      Must Be Taking:Tetracycline Antibiotics

      30 Participants Needed

      Antimicrobial Wash for Shoulder Replacement Surgery

      Detroit, Michigan
      The purpose of this randomized controlled trial is to determine the effect of post-incision wash using various novel antimicrobial solutions on the rate of positive C. Acnes cultures collected from adults undergoing primary shoulder replacement surgery. Subjects will be randomly assigned in a 1:1:1:1 fashion to groups that will receive one of the following treatments: * Post-incision application of Xperience Antimicrobial wash (NextScience, Jacksonville, FL) * Post-incision application of 3% hydrogen peroxide * Post-incision application of 10% povidone-iodine (betadine) * No post-incision treatment (control) The investigators hypothesize that the subjects treated with the antimicrobial solutions after initial incision will have lower rates of positive C. Acnes cultures. The investigators also hypothesize that post-incision application of Xperience Antimicrobial wash and Betadine will have an equal reduction in the incidence of C. acnes as Hydrogen Peroxide.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased

      Key Eligibility Criteria

      Disqualifiers:Cancer, Autoimmune Disorders, Others

      150 Participants Needed

      ATI-045 for Eczema

      Indianapolis, Indiana
      This study evaluates ATI-045 versus placebo in patients with Moderate-to-Severe Atopic Dermatitis.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Anaphylaxis, Corticosteroid Allergy, Others
      Must Not Be Taking:Antibiotics, Corticosteroids, Biologics, Others

      96 Participants Needed

      Remibrutinib for Hidradenitis Suppurativa

      Pittsburgh, Pennsylvania
      The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) Dose A and Dose B compared to placebo in participants with moderate to severe hidradenitis suppurativa (HS).
      Prior Safety Data
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Hepatic Disease, Cardiovascular, Neurological, Others
      Must Not Be Taking:BTK Inhibitors, Anti-coagulants

      555 Participants Needed

      Social Skin for Acne

      London, Ontario
      The goal of this interventional clinical trial is to investigate the efficacy and safety of GenLabs' Social Skin on improving acne symptoms and skin repair among healthy adults. The main question\[s\] it aims to answer is: What is the difference in the change in acne symptoms as assessed by the Acne Quality of Life Questionnaire (ACNE-QoL) between GenLabs' Social Skin and placebo from baseline at Day 30.

      Trial Details

      Trial Status:Not Yet Recruiting
      Trial Phase:Unphased
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Autoimmune, Diabetes, Hypertension, Others

      150 Participants Needed

      Subcision for Acne Scars

      Chicago, Illinois
      This trial is testing whether doing a minor surgical procedure called subcision can improve rolling acne scars. Subcision involves using a needle to cut through tough bands under the skin that cause scarring. The goal is to see if this method makes the skin look smoother compared to no treatment.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Mental Illness, Blood Diseases, Others
      Must Not Be Taking:Accutane

      5 Participants Needed

      Subcision + Suction for Acne Scars

      Chicago, Illinois
      This trial is testing whether using a suction device along with regular acne scar treatments helps improve the scars more than using the regular treatment alone. It targets people with acne scars and aims to see if suction can make the treatment work better by enhancing healing and cleaning.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Unphased
      Age:18 - 65

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Mental Illness, Scarring, Others
      Must Not Be Taking:Accutane

      20 Participants Needed

      Injectable Gel for Acne Scars

      Burlington, Ontario
      This trial is testing a new gel called ELAPR002f to help fill in and smooth out indented acne scars on the face. It targets adults with noticeable acne scars who haven't had success with other treatments. The gel works by filling in the scarred areas to make the skin look smoother. Participants will receive multiple treatments and be monitored for an extended period.
      No Placebo Group
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 3

      Key Eligibility Criteria

      Disqualifiers:Clinically Significant Acne, Autoimmune Disease, Lung Disease, Others

      157 Participants Needed

      Why Other Patients Applied

      "As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."

      IZ
      Healthy Volunteer PatientAge: 38

      "I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."

      WR
      Obesity PatientAge: 58

      "My orthopedist recommended a half replacement of my right knee. I have had both hips replaced. Currently have arthritis in knee, shoulder, and thumb. I want to avoid surgery, and I'm open-minded about trying a trial before using surgery as a last resort."

      HZ
      Arthritis PatientAge: 78

      "I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."

      ZS
      Depression PatientAge: 51

      "I was diagnosed with stage 4 pancreatic cancer three months ago, metastatic to my liver, and I have been receiving and responding well to chemotherapy. My blood work revealed that my tumor markers have gone from 2600 in the beginning to 173 as of now, even with the delay in treatment, they are not going up. CT Scans reveal they have been shrinking as well. However, chemo is seriously deteriorating my body. I have 4 more treatments to go in this 12 treatment cycle. I am just interested in learning about my other options, if any are available to me."

      ID
      Pancreatic Cancer PatientAge: 40
      Match to a Acne Trial

      Mosaic Laser Treatment for Skin and Hair Conditions

      Lincolnshire, Illinois
      This trial is testing a laser treatment called the Mosaic Ultra 1550nm system. It aims to help people with skin problems like wrinkles, scars, and acne. The laser works by boosting the skin's natural healing process to make it look smoother and younger. The 1550 nm laser device has been previously studied for its safety and effectiveness in improving wrinkles, pigmentation, and skin texture.
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Unphased
      Age:18 - 60

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Smoking, Heart Failure, Others
      Must Not Be Taking:Antiplatelets, Anticoagulants, Steroids, Others

      200 Participants Needed

      Topical Acne Medications for Acne

      Winston-Salem, North Carolina
      Acne is a chronic condition that typically requires the use of multiple medications.1 Medication adherence is especially challenging for patients with chronic diseases and often decreases over time, especially for those using topical medications.1 Nonadherence can result in multiple negative effects including treatment failure, increased healthcare costs, and decreased quality of life. Primary nonadherence refers to problems acquiring and starting treatment. Challenges to this form of nonadherence include a lack of knowledge, misunderstanding of usage, poor communication with provider, increased cost, and fear of side effects.2 Secondary nonadherence refers to when the patient does not use the medication as prescribed. Hurdles to secondary nonadherence include delayed results, increased complexity of treatment plan, adverse effects, busy lifestyle, and inconvenience.2
      No Placebo Group

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Early Phase 1

      Key Eligibility Criteria

      Disqualifiers:Under 18, No Acne, Others

      72 Participants Needed

      Clascoterone Cream for Acne

      High Point, North Carolina
      to compare facial sebaceous gland morphology after 3 months of clascoterone cream 1% treatment and to compare facial sebum constituents at baseline to facial sebum constituents after 3 months of clascoterone cream 1% treatment
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 4
      Age:18 - 35

      Key Eligibility Criteria

      Disqualifiers:Dermatological Disorders, Unstable Medical Disorders, Others
      Must Not Be Taking:Topical Prescriptions, OTC Products

      10 Participants Needed

      Gene Therapy for Chronic Granulomatous Disease

      Bethesda, Maryland
      Background: Chronic granulomatous disease (CGD) is a genetic disorder. People with CGD are missing a gene that affects their white blood cells. White cells are part of the immune system, and people with GCD are vulnerable to many infections. Researchers want to test a new treatment to replace the missing gene that may be safer than the current treatment for CGD. Objective: To test a new type of gene therapy in people with CGD. Eligibility: People aged 3 years or older with CGD. Design: Participants will undergo apheresis: Blood will be collected through a tube attached to a needle inserted in a vein; the blood will run through a machine that separates certain cells (stem cells); the remaining blood will be returned to the body through a second needle. The participant s stem cells will be modified in a laboratory to add the gene they are missing. Participants will stay in the hospital for about 40 days. For the first 10 days, they will undergo many exams, including imaging scans and tests of their heart and lung function. They will receive drugs to prepare their bodies for the gene therapy. They will receive a "central line": A hollow tube will be inserted into a vein in the chest, with a port opening above the skin. This port will be used to draw blood and administer drugs without the need for new needle sticks. For the gene therapy, each participant s own modified stem cells will be put into their body through the port. Participants will have 8 follow-up visits over 3 years.
      No Placebo Group

      Trial Details

      Trial Status:Enrolling By Invitation
      Trial Phase:Phase 1, 2
      Age:3 - 65

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, HIV, Hepatitis, Anemia, Others
      Must Not Be Taking:Gamma-interferon

      10 Participants Needed

      Clascoterone Cream for Acne

      High Point, North Carolina
      The etiology of acne is heavily dependent on the production of sebum by the sebaceous glands that results in the growth of the bacteria c. acnes. If no sebum is present, there is no nutritional source for the c. acnes, the bacteria die, and acne resolves. A newly FDA approved acne medication consisting of clascoterone cream 1% is believed to effectively treat acne due to a decrease in sebum production. This mechanism of action has been postulated based on efficacy observed in the phase III trials that lead to its approval. This research aims to demonstrate the effect of clascoterone cream 1% in sebum reduction.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Age:12+

      Key Eligibility Criteria

      Disqualifiers:Not Listed

      40 Participants Needed

      Retinol for Skin Aging

      High Point, North Carolina
      This study is being conducted to confirm whether skin tape stripping methodology can identify changes in gene expression (i.e. whether different genes are turned on to make proteins) in aged skin after use of a retinoid.
      No Placebo Group

      Trial Details

      Trial Status:Active Not Recruiting
      Age:40 - 65
      Sex:Female

      Key Eligibility Criteria

      Disqualifiers:Not Listed

      60 Participants Needed

      Antibiotics and Bleach Baths for Eczema

      Bethesda, Maryland
      Background: \- Atopic dermatitis, or eczema, is a chronic skin disorder. Patients sometimes have infections with S. aureus bacteria. Researchers want to study how eczema treatments affect the number and the type of bacteria on the skin. Objectives: \- To study the effect of eczema treatments on skin bacteria. Eligibility: * Individuals between 2 and 25 years of age who have moderate to severe atopic dermatitis. * Healthy volunteers between 18 and 40 years of age with no history of eczema. Design: * Participants will be screened with a physical exam and medical history. Research samples will be collected. Skin biopsies may also be performed. * All participants will be assigned to one of several study groups. * Healthy volunteers must not have taken antibiotics in the year before the start of the study. * All participants will have regular study visits during their 1-year participation. More research samples will be collected at these visits. * Healthy volunteers may be asked to come in for a one-time follow up after the 1 year mark.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 2
      Age:2 - 50

      Key Eligibility Criteria

      Disqualifiers:Pregnancy, Immunodeficiency, Chronic Illnesses, Others
      Must Not Be Taking:Antibiotics, Corticosteroids, CAM Agents

      130 Participants Needed

      ELAPR002f Gel for Acne Scars

      Arlington, Virginia
      Atrophic acne scars are flat, indented or with an inverted center scars that develop at the endpoint of the normal healing process for acne. Acne scarring that remains after acne resolves has a significant impact on health related quality of life, including reduced self-esteem and embarrassment/self consciousness. ELAPR002f provides an immediate space-occupying effect for filling in the scar tissue. The purpose of this study is to assess how safe and effective ELAPR002f injectable gel is on adult participants with atrophic acne scars. ELAPR002f injectable gel is an investigational device being developed for the treatment of facial atrophic acne scars. There are 2 cohorts in this study. In Cohort 1, all participants will receive ELAPR002f injectable gel. In Cohort 2, participants are placed in 1 of 2 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to the saline active control group. Around 395 adult participants with moderate to severe atrophic acne scarring on both cheeks will be screened in the study in approximately 25 sites in the United States. Participants will receive 3 treatments over 2 months of intradermal injections of either ELAPR002f injectable gel or saline active control and will be followed for up to an additional 12 months. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
      No Placebo Group
      Pivotal Trial (Near Approval)

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 3
      Age:22+

      Key Eligibility Criteria

      Disqualifiers:Significant Acne, Rosacea, Ice Pick Scars, Others

      395 Participants Needed

      HT-001 for Skin Side Effects from Cancer Therapy

      Washington D.C., District of Columbia
      The goal of this clinical trial is to learn about HT-001 Topical Gel for treatment of EGFR inhibitor-induced skin toxicities. The main questions it aims to answer are: * Determine the therapeutic effect of HT-001 for treatment of patients who develop acneiform rash undergoing Epidermal Growth Factor inhibitor (EGFRI) therapy using the acneiform rash investigator's global assessment scale \[ARIGA\] * Evaluate the safety of HT-001 during treatment Participants will apply HT-001 Gel once per day for 6 weeks, during which the effect on treating acneiform rash or other skin disorders induced by EGFRI therapy will be evaluated using different assessment tools to measure severity of rash, pain, and itching (pruritus), as well as the change in quality of life. The study will be completed in 2 periods: the first period is open-label (unblinded) and all patients will receive HT-001 topical gel with the active ingredient; the second period is blinded and patients will be randomized to receive one of three concentrations of HT-001 or placebo. Researchers will compare HT-001 to the placebo in the second period to see if HT-001 provides a significant treatment effect.

      Trial Details

      Trial Status:Recruiting
      Trial Phase:Phase 2

      Key Eligibility Criteria

      Disqualifiers:Severe Toxicity, Skin Disorders, Others
      Must Be Taking:EGFR Inhibitors

      152 Participants Needed

      Photodynamic Therapy for Acne

      Tampa, Florida
      The aim of this study is to test the safety and efficacy of photodynamic therapy (PDT) for the medication Ameluz® performed with the PDT-lamp BF-RhodoLED® in comparison to the respective placebo treatment for moderate to severe Acne vulgaris.

      Trial Details

      Trial Status:Active Not Recruiting
      Trial Phase:Phase 2
      Age:16+

      Key Eligibility Criteria

      Disqualifiers:Hypersensitivity, Soy Allergy, Atopic Dermatitis, Others
      Must Not Be Taking:Antibiotics, Isotretinoin, Immunosuppressants, Others

      126 Participants Needed

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      We started Power when my dad was diagnosed with multiple myeloma, and I struggled to help him access the latest immunotherapy. Hopefully Power makes it simpler for you to explore promising new treatments, during what is probably a difficult time.

      Bask
      Bask GillCEO at Power
      Learn More About Trials
      How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?
      Match to a Trial
      Match to a Trial

      Frequently Asked Questions

      How much do Acne clinical trials pay?

      Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.

      How do Acne clinical trials work?

      After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Acne trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Acne is 12 months.

      How do I participate in a study as a "healthy volunteer"?

      Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.

      What does the "phase" of a clinical trial mean?

      The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.

      Do I need to be insured to participate in a Acne medical study?

      Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

      What are the newest Acne clinical trials?

      Most recently, we added ELAPR002f Gel for Acne Scars, Social Skin for Acne and ATR04-484 for Acneiform Rash to the Power online platform.

      What is the permanent cure for acne?

      There isn’t a one-time, permanent cure for acne—skin, hormones and genetics can always change—so doctors focus on long-term control. A single 4-6-month course of oral isotretinoin keeps roughly 70-85 % of patients clear for years, but up to one-third may need another course and the drug requires strict pregnancy prevention, blood tests and monitoring for side-effects. If acne returns or isotretinoin isn’t suitable, topical retinoids, benzoyl peroxide, short antibiotic courses or hormonal medicines can keep break-outs in check, so working with a dermatologist to tailor a plan is key.

      Are clinical trials worth doing?

      Clinical trials can be worthwhile if you are comfortable balancing potential benefits—access to cutting-edge therapy, closer medical monitoring, and helping advance science—against possible downsides such as unknown side-effects, more clinic visits, or being assigned to the standard-care or placebo group. Ask the study team about the purpose, possible risks, time commitment, and what happens after the trial; then weigh these facts against your current treatment options and personal priorities to decide whether joining fits your situation.

      What is similar to Accutane?

      Medications most like Accutane are other oral retinoids that shrink oil glands: different brands/generics of isotretinoin (Claravis, Absorica, Amnesteem, Myorisan, etc.) and, where available, alitretinoin or acitretin, which work similarly but have limited approval or longer pregnancy-avoidance rules. Treatments such as antibiotics, birth-control pills, spironolactone, or laser devices can improve acne, yet they control symptoms rather than permanently reset the oil gland the way Accutane and its sister retinoids do.

      Where does the pus go if you don't pop a pimple?

      If you leave a pimple alone, one of two things happens: in shallow whiteheads the clogged pore eventually opens so a tiny amount of pus comes out, dries, and washes away, while in deeper bumps your immune cells break the pus down and the fluid is carried off through nearby lymph and blood vessels. Either way the material is cleared within days to weeks, so the bump flattens on its own. Squeezing can rupture the pore and push bacteria deeper, so use warm compresses and see a clinician if a lesion is very large, painful, or red and spreading.

      Did people have acne 500 years ago?

      Yes. Puberty triggers the same oil-gland and bacterial changes now as it did centuries ago, so adolescents 500 years ago (and far earlier) got pimples too. Physicians from Hippocrates in ancient Greece to Girolamo Mercuriale in 16th-century Italy wrote about—and tried to treat—these facial “pustules,” confirming that acne is a timeless human condition.

      Which is better for acne, spironolactone or Accutane?

      Think of the two medicines as tools for different jobs: Accutane (isotretinoin) is usually chosen when acne is severe, scarring, or unresponsive to other treatments in any gender, while spironolactone mainly helps adult women whose breakouts flare with hormones. Accutane is a short, one-time 4-6-month course but demands strict birth-control and monthly lab checks; spironolactone is an ongoing daily pill that stops working if you stop it and needs only occasional potassium tests. Your dermatologist will match the drug (or sometimes both in sequence) to your acne pattern, gender, and comfort with these safety rules.

      Does tea tree oil actually help acne?

      Small but good-quality studies suggest a 5 % tea tree oil gel can modestly shrink inflamed and clogged pores, performing similarly to standard 5 % benzoyl-peroxide but taking longer to show results. It is safest as a once- or twice-daily spot treatment for mild acne—first patch-test and stick to products that clearly state the concentration—while seeking medical advice for ongoing or severe breakouts and never swallowing the oil.

      Why is Accutane a last resort?

      Accutane is held back until the end because, although it can permanently clear severe acne, it also carries serious risks—especially birth defects—and requires strict birth-control rules, regular blood tests, and close doctor follow-up. Dermatologists therefore try safer options first (topical retinoids, benzoyl peroxide, antibiotics, hormonal pills) and turn to Accutane only when acne is severe, scarring, or hasn’t responded to those therapies.

      How to tell if acne is hormonal or bacterial?

      Nearly all acne contains skin bacteria; the tell-tale sign it’s “hormonal” is a predictable surge of deep, tender cysts along the jaw or chin that spike around periods, pregnancy, or a change in birth-control—situations that usually respond best to therapies that calm androgens (certain oral contraceptives, spironolactone). If break-outs are mainly scattered whiteheads, blackheads, or small red pimples that improve with benzoyl-peroxide or topical retinoids, clogged pores and bacterial overgrowth are probably the main issue; give an OTC benzoyl-peroxide + adapalene routine 6–8 weeks and see a dermatologist sooner for scarring cysts, irregular periods, or no improvement.

      Why did prednisone clear up my acne?

      Prednisone is a powerful anti-inflammatory drug; by rapidly shutting down the chemical signals that make pimples red, swollen, and painful, it can make skin look clearer within days. But it doesn’t fix the root causes of acne (excess oil, clogged pores, hormones), and as the dose is lowered those factors return—sometimes with extra “steroid acne” caused by the medicine itself—so it’s only used as a short-term rescue, not a long-term solution.