Social Skin for Acne

Overseen By Marc Moulin, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: GenCanna Acquisition Corp

Disqualifiers: Pregnancy, Autoimmune, Diabetes, Hypertension, others

Compensation: Varies

Number of Visits: Unknown

Duration: 4 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new skincare treatment called Social Skin to determine its effectiveness in improving acne symptoms and repairing skin. Researchers aim to find out if Social Skin, which contains natural extracts such as peppermint and willow bark, outperforms a placebo (a treatment with no active ingredients). The trial targets healthy adults with visible facial acne who are willing to adhere to the study guidelines and maintain their current skincare routines. As an unphased trial, participants can contribute to groundbreaking research in skincare innovation.

Do I have to stop taking my current medications for the trial?

The trial requires you to maintain your current medications as much as possible, but you cannot use any that might impact the study's safety or effectiveness. Check with the study team to see if your medications are allowed.

Is there any evidence suggesting that Social Skin is likely to be safe for humans?

Research shows that the main ingredient in Social Skin, ProRenew Complex CLR, is generally safe. This ingredient comes from a type of bacteria known as Lactococcus lactis and is fermented to produce a substance that helps maintain skin balance and protection.

Studies on ProRenew Complex CLR indicate it is well-tolerated, with no major side effects reported in the available data. This suggests it is likely safe for skin use, with a low risk of side effects. However, as with any new product, a small chance of minor skin irritation or an allergic reaction exists, so monitoring skin response is important. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike most acne treatments that often rely on antibiotics or retinoids, Social Skin uses a unique formula that includes ProRenew Complex CLRTM, which incorporates Lactococcus ferment lysate. This ingredient is derived from beneficial bacteria, L. lactis, and is combined with natural extracts like peppermint, willow bark, and lentil seed. Researchers are excited about Social Skin because it offers a novel approach to acne treatment by potentially supporting the skin's natural renewal process and reducing inflammation without the harsh side effects often associated with traditional acne medications.

What evidence suggests that Social Skin might be an effective treatment for acne?

Research shows that Social Skin, the investigational product in this trial containing ProRenew Complex CLRTM, may help treat acne. Studies have demonstrated that this complex improves the skin's protective barrier and renews the skin's surface, which is important for reducing acne symptoms. Another study found that similar postbiotic treatments led to noticeable reductions in acne spots. Over 24 weeks, this treatment also reduced scarring more effectively than a placebo. Overall, these findings suggest that Social Skin could effectively improve acne symptoms and skin health. ^{6 7 8 9 10}

Who Is on the Research Team?

David Crowley, MD

Principal Investigator

KGK Science Inc.

Are You a Good Fit for This Trial?

This trial is for healthy adults with acne. Participants must have a certain severity of acne but be generally healthy without any serious skin conditions or allergies to ingredients in the Social Skin product.

Inclusion Criteria

I have visible acne on my face confirmed by a professional.

I am not able to have children, either due to surgery, being post-menopausal for over a year, or I am using birth control.

I agree to not change my current lifestyle habits.

Exclusion Criteria

Individuals who are pregnant, breast feeding, or planning to become pregnant

Autoimmune disease or immune compromised

I have not had major surgery in the last 3 months and do not plan any during the study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive GenLabs' Social Skin or placebo to assess changes in acne symptoms and skin repair

4 weeks

Virtual visits throughout the treatment period

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Social Skin

Trial Overview The study tests GenLabs' Social Skin, a new treatment for acne, against a placebo. The main focus is on how much it improves acne symptoms and aids skin repair by Day 30, measured by the Acne Quality of Life Questionnaire (ACNE-QoL).

How Is the Trial Designed?

Group I: Social Skin Experimental Treatment 1 Intervention

The investigational product in this study contains ProRenew Complex CLRTM, which is a three-step skin regime targeting acne comprised of Lactococcus ferment lysate, derived from L. lactis, in addition to peppermint, willow bark, and lentil seed extracts.

Group II: Placebo Placebo Group 1 Intervention

This group receives a placebo containing non-medicinal ingredients in Social Skin, in a three-step skin regime.

Who Is Running the Clinical Trial?

GenCanna Acquisition Corp

Lead Sponsor

KGK Science Inc.

Industry Sponsor

Trials

82

Recruited

6,400+

Najla Guthrie

KGK Science Inc.

Chief Executive Officer since 1997

Research career at the Centre for Human Nutrition, University of Western Ontario

Dr. Bibiane Zakaria

KGK Science Inc.

Chief Medical Officer since 2023

MD from an unspecified institution

Citations

1. clr-berlin.com clr-berlin.com/new-data-on-the-skin-microbiota-with-prorenew-complex-clr/

New data on the skin microbiota It improves skin barrier function and skin resurfacing. Independent studies showed that it positively influences the skin hydration level and stabilizes skin ...

2. mdpi.com mdpi.com/2311-5637/9/3/264

Production, Formulation, Application of Postbiotics for Skin This review aims to present the importance of microorganisms in maintaining skin homeostasis and to provide an overview of the production, formulations, and ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11266290/

Acne treatment: research progress and new perspectives In a 24 weeks study, it showed a higher likelihood of reducing scarring compared to the placebo.

4. dermatologytimes.com dermatologytimes.com/view/efficacy-of-combining-postbiotic-formulation-with-microneedling-for-acne

Efficacy of Postbiotic & Microneedling for Acne SSRI analysis showed moderate to excellent improvement in 100% of patients. Representative cases demonstrated marked reductions in acne lesions, ...

5. cossma.com cossma.com/ingredients/article/clr-presents-new-data-on-the-skin-microbiota-35877.html?L=1

CLR presents new data on the skin microbiota - COSSMA CLR announces new test results for its cosmetic active ProRenew Complex CLR™, a postbiotic ingredient which both improves and accelerates ...

6. scribd.com scribd.com/document/509994020/ProRenew-Complex-CLR-SDS

ProRenew Complex CLR SDS | PDF | Toxicity ProRenew Complex CLR is obtained from a lysate of the Gram positive bacterial species Lactococcus lactis, which is fermented under special conditions of ...

7. clr-berlin.com clr-berlin.com/products/prorenew-complex-clr/

ProRenew Complex CLR ProRenew Complex CLR™ is beneficial for both the health of skin and the skin microbiota. It balances and protects the skin microbiota and supports it in dealing ...

8. pub-mediabox-storage.rxweb-prd.com pub-mediabox-storage.rxweb-prd.com/exhibitor/document/exh-26a88a5f-a8c3-4763-b426-31a2894c3d7c/4b17c87d-7161-42e2-88b7-5ee2e8407972.pdf

CLR Product Overview Repair Complex CLR™ PF is a biotechnological anti-aging active, obtained from a lysate of probiotic bifidobacteria, which potently protects against UV-induced ...

9. deverauxspecialties.com deverauxspecialties.com/product/prorenew-complex-clr/

ProRenew Complex CLR ProRenew Complex CLR™ is a multifunctional ingredient designed to rejuvenate skin and scalp by accelerating epidermal growth and enhancing the skin's ...

10. knowde.com knowde.com/stores/clr-berlin-gmbh/products/clr-berlin-gmbh-prorenew-complex-clr

ProRenew Complex CLR - Lactococcus Ferment Lysate Safety Data Sheet. ProRenew Complex CLR™ Safety Data Sheet. View. Enhanced TDS. Knowde-enriched technical product data sheet. Expand All. Identification ...