FLASH Radiotherapy for Bone Metastases in the Thorax

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Bone Metastases in the Thorax+3 More
FLASH Radiotherapy - Radiation
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

The purpose of this study is to assess toxicities of FLASH radiotherapy treatment and pain relief in subjects with painful thoracic bone metastases. FLASH radiotherapy is radiation treatment delivered at ultra-high dose rates compared to conventional radiation treatment.

Eligible Conditions

  • Bone Metastases in the Thorax

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Bone Metastases in the Thorax

Study Objectives

4 Primary · 2 Secondary · Reporting Duration: Assessed from start of treatment until 6 months post treatment.

Month 6
Assessment of radiation-related toxicities that are possibly, probably, or definitely related to FLASH radiotherapy.
Month 3
Assessment of pain relief using patient reported pain questionnaire for pain at treated site
Month 3
Use of pain medication
Month 3
Assessment of pain relief using patient reported pain questionnaire for overall pain score
Week 4
Workflow feasibility - delays in study treatment
Workflow feasibility - time on table

Trial Safety

Safety Progress

1 of 3

Other trials for Bone Metastases in the Thorax

Trial Design

1 Treatment Group

FLASH radiotherapy for painful bone metastasis(-es)
1 of 1
Experimental Treatment

10 Total Participants · 1 Treatment Group

Primary Treatment: FLASH Radiotherapy · No Placebo Group · N/A

FLASH radiotherapy for painful bone metastasis(-es)
Radiation
Experimental Group · 1 Intervention: FLASH Radiotherapy · Intervention Types: Radiation

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: assessed from start of treatment until 6 months post treatment.
Closest Location: Cincinnati Children's Hospital Medical Center · Cincinnati, OH
Photo of Cincinnati 1Photo of Cincinnati 2Photo of Cincinnati 3
2011First Recorded Clinical Trial
1 TrialsResearching Bone Metastases in the Thorax
706 CompletedClinical Trials

Who is running the clinical trial?

Varian, a Siemens Healthineers CompanyLead Sponsor
17 Previous Clinical Trials
6,025 Total Patients Enrolled
John Breneman, MDPrincipal InvestigatorMedical Director Cincinnati Children's/UC Health Proton Therapy Center
1 Previous Clinical Trials
10 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You are at least 18 years old.
Bone metastases that can be treated within a field size up to 7.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.