Paracaine
Local Anaesthesia therapy
Treatment
0 Active Studies for Paracaine
Treatment for
Local Anaesthesia therapy
What is Paracaine
Proparacaine
The Generic name of this drug
Treatment Summary
Proparacaine is a local anesthetic used to numb the surface of the eye. It is applied as an ophthalmic solution at a concentration of 0.5% in the form of hydrochloride salt.
Alcaine
is the brand name
Paracaine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Alcaine
Proparacaine
1973
24
Effectiveness
How Paracaine Affects Patients
Proparacaine works by blocking the flow of ions that cause nerve impulses, numbing the area it is applied to. It does this by binding to and blocking the action of certain sodium channels.
How Paracaine works in the body
Proparacaine works by limiting sodium's ability to pass through the nerve cell membrane. It does this by interacting with the protein residues that make up the cell membrane, effectively blocking the necessary changes that create an action potential. We don't know exactly how it works, but this is the most likely explanation.
When to interrupt dosage
The measure of Paracaine is contingent upon the diagnosed case. The amount of dosage may differ, as per the approach of delivery (e.g. Ophthalmic or Solution / drops) listed in the table below.
Condition
Dosage
Administration
Local Anaesthesia therapy
, 5.0 mg/mL, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Ophthalmic; Topical, Solution - Ophthalmic; Topical
Warnings
There are 4 known major drug interactions with Paracaine.
Common Paracaine Drug Interactions
Drug Name
Risk Level
Description
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Proparacaine is combined with Oliceridine.
Daridorexant
Minor
The risk or severity of CNS depression can be increased when Proparacaine is combined with Daridorexant.
Fluoxetine
Moderate
Proparacaine may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Ziprasidone
Moderate
The risk or severity of adverse effects can be increased when Proparacaine is combined with Ziprasidone.
Paracaine Novel Uses: Which Conditions Have a Clinical Trial Featuring Paracaine?
No active studies are currently exploring the potential of Paracaine in providing Local Anesthesia.
Condition
Clinical Trials
Trial Phases
Local Anaesthesia therapy
0 Actively Recruiting
Paracaine Reviews: What are patients saying about Paracaine?
4
Patient Review
1/12/2009
Paracaine for Anesthesia of the Cornea of the Eye
1
Patient Review
7/31/2009
Paracaine for Local Anesthesia for Eye Surgery
Patient Q&A Section about paracaine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What class of drug is proparacaine?
"Proparacaine is a type of local anesthetic that works quickly."
Answered by AI
What is proparacaine used for?
"The Proparacaine eye drops work by numbing the eye to prevent pain during surgery, certain tests, or procedures. The drops block the pain signals at the nerve endings in the eye."
Answered by AI
How often can you use proparacaine eye drops?
"Your provider will give you 1 drop of proparacaine (Alcaine) every 5 to 10 minutes for up to 5 to 7 doses for short procedures on the eye. You won't be able to take any more because the medication is only for short-term use."
Answered by AI
Can humans use proparacaine?
"The long-term side effects of Proparacaine are unknown; prolonged use may possibly delay wound healing. Proparacaine should be used cautiously and sparingly in patients with known allergies, cardiac disease, or hyperthyroidism."
Answered by AI