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MDMA for Social Interactions (DEI Trial)

Phase < 1
Waitlist Available
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up time frame: baseline-72 hours after completion of the sessions
Awards & highlights

DEI Trial Summary

This study is evaluating whether MDMA can make people feel closer to a stranger.

DEI Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time frame: baseline-72 hours after completion of the sessions
This trial's timeline: 3 weeks for screening, Varies for treatment, and time frame: baseline-72 hours after completion of the sessions for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Profile of Mood States

Side effects data

From 2018 Phase 1 & 2 trial • 12 Patients • NCT02876172
33%
Anxiety
17%
Nasal congestion
17%
Rash
17%
Dyspnoea
17%
Visual Impairment
17%
Vomiting
17%
Upper respiratory tract infection
17%
Arthropod bite
17%
Disturbance in attention
17%
Paresthesia
17%
Oropharyngeal pain
17%
Pruritis
17%
Dizziness
17%
Insomnia
17%
Rhinorrhoea
100%
80%
60%
40%
20%
0%
Study treatment Arm
CSO Patients Open-label CBCT and MDMA-assisted Therapy (up to 2 Months Post Last Experimental Dose)
CSO Patients at 6-month Follow-up
PTSD Patients at 6-month Follow-up
PTSD Patients Open-label CBCT and MDMA-assisted Therapy (up to 2 Months Post Last Experimental Dose)

DEI Trial Design

2Treatment groups
Experimental Treatment
Group I: Experimental: Placebo Then MDMAExperimental Treatment2 Interventions
Participants first receive placebo at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive 100 mg MDMA.
Group II: Experimental: MDMA Then PlaceboExperimental Treatment2 Interventions
Participants first receive 100 mg MDMA at their first session in the laboratory. Then will return to the laboratory 72 hours later and will receive placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
placebo oral tablet
2021
Completed Early Phase 1
~80
MDMA
2001
Completed Phase 2
~390

Find a Location

Who is running the clinical trial?

University of ChicagoLead Sponsor
1,001 Previous Clinical Trials
817,700 Total Patients Enrolled
1 Trials studying Social Interactions
34 Patients Enrolled for Social Interactions

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Illinois
Texas
How old are they?
18 - 65
What site did they apply to?
University of Chicago
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria

How responsive is this trial?

Typically responds via
Phone Call
Recent research and studies
clinicaltrials.govStudy
Drug Effects on Interpersonal Interaction
2021. "Drug Effects on Interpersonal Interaction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05123716.
~8 spots leftby Apr 2025
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